Immunological Approaches to Contraception and Promotion of Fertility

Immunological Approaches to Contraception and Promotion of Fertility PDF

Author: Gursaran Talwar

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 433

ISBN-13: 1468451405

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Contraceptive research has entered the new age of vaccines. Realistic prospects exist for the development of an entirely new battery of vaccines for use in human and veterinary medicine. Among them may be anti-fertility vaccines, based on physiological mechanisms applicable to either the female or male. This volume is a comprehensive review - a status report - of the subjects including fundamental work on the search for useful epitopes and ranging to applied vaccinology. One vaccine to prevent pregnancy, for use by women, has already been studied extensively. G.P. Talwar, the volume's editor and his colleagues in New Oelhi, India, published in 1976 a landmark series of papers describing the immunological properties of a preparation consisting of the alum-precipitated beta-subunit of human chorionic gonadotropin (hCG) chemically linked to tetanus toxoid. The principle of enhancing antigenicity of a self-protein by linkage of the epitope to a carrier protein was employed and tested clinically. These trials, carried out under the auspices of the Indian Council for Medical Research, were the first application of the carrier protein concept for a vaccine for human use. The encouraging results stimulated a wave of research not only on the use of hCG-based vaccines, but on other antigens as well.

Immunological Aspects of Reproduction and Fertility Control

Immunological Aspects of Reproduction and Fertility Control PDF

Author: J.P. Hearn

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 253

ISBN-13: 9401180393

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The no-man's-land between reproductive physiology and immunology is becoming crowded. The last 10 years have seen a revolution in our under standing of many reproductive processes, brought about by the application of ever more sophisticated immunological methods. The increasing precision of these techniques has given us specific ways of assaying, enhancing or blocking hormonal mechanisms to yield more critical and interpretable information. In this volume eleven authors have presented the current status and future prospects of some immunological aspects of reproduction and fertility con trol. These include the relationships between mother and fetus, the diagnosis of pregnancy, the immunological complications seen in clinical management of human reproduction and some novel approaches for immunological control of fertility. We hope that in these chapters we have achieved an up-to-date account of a fast-moving field that calls on several disciplines. We intend the book to provide an adequate background and a current review for research workers and clinicians who wish both to understand the complex mechanisms involved and to develop improved scientific and clinical methods. We hope too that the student and newcomer will find this a useful reference book.

Contraceptive Research and Development

Contraceptive Research and Development PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1996-11-04

Total Pages: 534

ISBN-13: 0309175658

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The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.

Immune Infertility

Immune Infertility PDF

Author: Walter K.H. Krause

Publisher: Springer

Published: 2016-11-02

Total Pages: 297

ISBN-13: 3319407880

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This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.

Female Contraception

Female Contraception PDF

Author: Benno Runnebaum

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 432

ISBN-13: 3642737900

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Contraceptives have always provided ground for controversy. This book describes and discusses latest findings concerning the advantages as well as hazard and risk factors of contraception. The clinical impact of oral contraceptives on metabolism is particularly highlighted. In addition, behavioral methods, intrauterine devices, implants and modern approaches in animal and clinical research in the field of immunization against pregnancy are considered. Last, but not least, the book summarizes the complex ethical, religious and political aspects of family planning and contraception.

Contraceptive Research and Development

Contraceptive Research and Development PDF

Author: Committee on Contraceptive Research and Development

Publisher: National Academies Press

Published: 1996-11-18

Total Pages: 535

ISBN-13: 030952251X

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The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.

Contraception Research for Today and the Nineties

Contraception Research for Today and the Nineties PDF

Author: G.P. Talwar

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 396

ISBN-13: 1461237467

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The twentieth century will close with 5 billion people added to the current global population. Between 1980 and the year 2000, the total world population will increase from 4 billion 10 a liUle over 6 billion. There will be half as many morc people on earth during these 20 years than the number accumulated since the origin of man to 1980. Overpopulation is particularly acute in economically developing countries, where contraception has become a social necessity. Comraceplion Researcll for Today and Ihe Nineties carries the proceedings of an international symposium convened in New Delhi in October, 1986, to review the status of current research in contraception. Major organizations supporting basic and applied research in contraception-The Population Council, World Health Organization (WHO), The Rockefeller Foundation, United States Agency for International Development (USAID), International Development Research Center of Canada (IDRC), National Institutes of Health (NIH), and the Indian Council of Medical Research (ICMR)- were represented by the heads of divi sions who projected respective programs and strategies. Principal scientists responsible for many of the new leads participated.

Contraceptive Use and Controlled Fertility

Contraceptive Use and Controlled Fertility PDF

Author: National Research Council

Publisher: National Academies Press

Published: 1989-02-01

Total Pages: 172

ISBN-13: 0309040965

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These four papers supplement the book Contraception and Reproduction: Health Consequences for Women and Children in the Developing World by bringing together data and analyses that would otherwise be difficult to obtain in a single source. The topics addressed are an analysis of the relationship between maternal mortality and changing reproductive patterns; the risks and benefits of contraception; the effects of changing reproductive patterns on infant health; and the psychosocial consequences to women of controlled fertility and contraceptive use.

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