Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders

Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders PDF

Author: Raphael Pinaud

Publisher: Springer Science & Business Media

Published: 2006-11-22

Total Pages: 298

ISBN-13: 0387336044

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This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits. In addition, the book explores roles of IEGs in clinical neuropathology.

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction PDF

Author: L. Kaczmarek

Publisher: Gulf Professional Publishing

Published: 2002-07-01

Total Pages: 390

ISBN-13: 9780080534466

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That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration. This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

Brain Aromatase, Estrogens, and Behavior

Brain Aromatase, Estrogens, and Behavior PDF

Author: Jacques Balthazart

Publisher: Oxford University Press

Published: 2012-09-21

Total Pages:

ISBN-13: 0199841209

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It is well known that the class of steroid hormones known as estrogens have powerful effects on organs related to reproduction such as the uterus and the breast. What is less well known is that estrogens also profoundly modulate brain function and behavior. Estrogens, such as estradiol, can occur in brain as the result of ovarian secretion of the hormone into the blood that then finds its way to the brain. In male vertebrates, the testes secrete androgens, such as testosterone, into the blood and this class of steroid hormones can be converted into estrogens in the brain via the action of the enzyme aromatase which is expressed in the male brain in many species. Finally estradiol can be synthesized de novo from cholesterol as it has been shown in a variety of species that all the enzymes required to synthesize estrogens are expressed in the brain. This book collects chapters by experts in the field that considers, how estradiol is synthesized in the brain and what its effects are on a variety of behaviors. Special attention is paid to the enzyme aromatase that is distributed in discrete regions of the brain and is highly regulated in a sex specific and seasonal specific manner. Recently it has become clear that estrogens can act in the brain at two very different time scales, one is rather long lasting (days to weeks) and involves the modulation of gene transcription by the hormone-receptor complex. A second mode of action is much quicker and involves the action of estrogens on cell membranes that can result in effects on second messenger systems and ultimately behavior within minutes. Thus this book highlights novel views of estrogen action that are still under-appreciated namely that estrogens have significant effects on the male brain and that they can act on two very different times scales. This volume will be of interest to both basic researchers and clinicians interested in the action of estrogens.

Neuroproteomics

Neuroproteomics PDF

Author: Oscar Alzate

Publisher: CRC Press

Published: 2009-10-26

Total Pages: 356

ISBN-13: 1420076264

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In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Rapid Eye Movement Sleep

Rapid Eye Movement Sleep PDF

Author: Birendra N. Mallick

Publisher: Cambridge University Press

Published: 2011-07-14

Total Pages: 529

ISBN-13: 1139503782

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Spanning over half a century of investigation into Rapid Eye Movement (REM) sleep, this volume provides comprehensive coverage of a broad range of topics in REM sleep biology. World renowned researchers and experts are brought together to discuss past and current research and to set the foundation for future developments. Key topics are covered in six sections from fundamental topics (historical context and general biology) to cutting-edge research on neuronal regulation, neuroanatomy and neurochemistry, functional significance and disturbance in the REM sleep generating mechanism. A reference source for all aspects of REM sleep research, it also incorporates chapters on neural modelling, findings from non-human species and interactions between brain regions. This is an invaluable resource, essential reading for all involved in sleep research and clinical practice.

Essential Leadership

Essential Leadership PDF

Author: Daniel Augusto Motta

Publisher: BMI Editora e Publicações LTDA

Published: 2017-11-10

Total Pages: 241

ISBN-13: 8593616011

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To the writer, Essential Leadership in based on three pillars —Personal Excellence, Individual Essence and Organization Transformation. Within this framework, a leader must understand, define, and impact an organization's strategy, seeing to its development and survival. Organizational objectives must be clear and aligned, and this is the mission of every leader, whatever the structure's size and complexity. To this end, leaders need to be aware of their three vectors —Adherence to Beliefs and Values, Consistent Productivity and Emotional Bond. ELOS Essential Leadership Skills for Organizational Strategy methodology is based on six elos, and each one has four drivers. The elos that need to be fully understood and cultivated are Competitive Environment, Value Proposition, Organization Essence, Strategic Execution, Essential Leadership and Performance Catalysts. This book also contains a rich, in-depth analysis of Europe's, China's and India's past, and points out to leaders the direction and the steps needed to redefine and achieve organizational goals. Forewords by two top executives and testimonials from six others are a testament to Motta's theory.

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics PDF

Author: Carl Faingold

Publisher: Academic Press

Published: 2013-12-26

Total Pages: 537

ISBN-13: 0124158641

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Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

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