How “Sputnik V or Gam-Covid-Vac.” works.

How “Sputnik V or Gam-Covid-Vac.” works. PDF

Author: Dr. Hakim. K. Saboowala

Publisher: Dr.Hakim Saboowala

Published: 2021-05-05

Total Pages: 18

ISBN-13:

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How “Sputnik V or Gam-Covid-Vac.” works. The Sputnik V vaccine, developed by Gamaleya National Research Institute of Epidemiology and Microbiology in Moscow, uses two different viruses that cause the common cold (adenovirus) in humans. · The adenoviruses are weakened so they cannot replicate in humans and cannot cause disease. · They are also modified so that the vaccine delivers a code for making the coronavirus spike protein. This aims to ensure that when the real virus tries to infect the body, it can mount an immune response in the form of antibodies. Sputnik uses a different vector for each of the two Jabs in a course of vaccination. Thus, using a different adenovirus vector may help create a more powerful immune response (compared with using the same vector twice), as it minimizes the risk of the immune system developing resistance to the initial vector. This provides immunity with a longer duration than vaccines using the same delivery mechanism for both shots, according to the Russian Direct Investment Fund (RDIF). Sputnik V is approved for use in over 55 countries with a total population of over 1.5 billion people, according to RDIF. Thus, an attempt has been made in this Booklet to describe“How Sputnik V or Gam-Covid-Vac. works.”, along with relevant Illustrations for better understanding! Although care has been taken while compiling and checking information given in this Booklet to ensure that it is accurate, and none shall be responsible, in any way, liable for contemporaneousness of this information or for any errors, omissions or inaccuracies in this publication. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Definition and Application of Terms for Vaccine Pharmacovigilance

Definition and Application of Terms for Vaccine Pharmacovigilance PDF

Author: Council for International Organizations of Medical Sciences (CIOMS)

Publisher:

Published: 2012

Total Pages: 0

ISBN-13: 9789290360834

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This report from the Council for International Organizations of Medical Sciences (CIOMS) in collaboration with WHO covers the activities and outputs of the CIOMS/WHO Working Group on Vaccine Pharmacovigilance (2005-2010). This working group brought together experts from both industrialized and emerging countries representing regulatory agencies, vaccine industry, national and international public health bodies including WHO and CIOMS, academia and clinical care, contributing from their different perspectives. The report covers general terms and definitions for vaccine safety and discusses the application of such harmonized tools in vaccine safety surveillance and studies. As well, the report highlights case definitions for adverse events typically reported for vaccines. The report is addressed to those engaged in vaccine safety data collection and evaluation, and will also make a useful reading for others who want to familiarize themselves with vaccine safety terminology.

Neurological Care and the COVID-19 Pandemic - E-Book

Neurological Care and the COVID-19 Pandemic - E-Book PDF

Author: Ahmad Riad Ramadan

Publisher: Elsevier Health Sciences

Published: 2021-08-26

Total Pages: 201

ISBN-13: 032382692X

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Offering a comprehensive review of the neuropathology of SARS-CoV-2, Neurological Care and the COVID-19 Pandemic provides up-to-date coverage of the wide array of the pathogen’s neurological symptoms and complications. Drs. Ahmad Riad Ramadan and Gamaledin Osman discuss the neuropathology of SARS-CoV-2, its neurological manifestations, and the impact the pandemic has had on the care of patients with pre-existing neurological conditions. The authors also offer an overview of emerging treatments and vaccines, as well as ways healthcare systems have reorganized in order to respond to the pandemic. Offers a thorough discussion of the impact the virus has had on the care of patients with neurological ailments, accompanied by recommendations on how to care for these patients. Covers the impact of COVID-19 on patients with cerebrovascular diseases, seizures, demyelinating diseases, neuromuscular disorders, movement disorders, headache disorders, cognitive disorders, and neuro-oncological disorders. Includes a detailed case study of how one healthcare system hit hard by COVID-19 successfully transformed itself to respond to the challenges imposed by the pandemic. Consolidates today’s available information on this timely topic into a single, convenient resource.

A Proposal to End the COVID-19 Pandemic

A Proposal to End the COVID-19 Pandemic PDF

Author: Ruchir Agarwal

Publisher: International Monetary Fund

Published: 2021-05-19

Total Pages: 54

ISBN-13: 1513577603

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Urgent steps are needed to arrest the rising human toll and economic strain from the COVID-19 pandemic that are exacerbating already-diverging recoveries. Pandemic policy is also economic policy as there is no durable end to the economic crisis without an end to the health crisis. Building on existing initiatives, this paper proposes pragmatic actions at the national and multilateral level to expeditiously defeat the pandemic. The proposal targets: (1) vaccinating at least 40 percent of the population in all countries by the end of 2021 and at least 60 percent by the first half of 2022, (2) tracking and insuring against downside risks, and (3) ensuring widespread testing and tracing, maintaining adequate stocks of therapeutics, and enforcing public health measures in places where vaccine coverage is low. The benefits of such measures at about $9 trillion far outweigh the costs which are estimated to be around $50 billion—of which $35 billion should be paid by grants from donors and the residual by national governments potentially with the support of concessional financing from bilateral and multilateral agencies. The grant funding gap identified by the Access to COVID-19 Tools (ACT) Accelerator amounts to about $22 billion, which the G20 recognizes as important to address. This leaves an estimated $13 billion in additional grant contributions needed to finance our proposal. Importantly, the strategy requires global cooperation to secure upfront financing, upfront vaccine donations, and at-risk investment to insure against downside risks for the world.

Learning from the COVID-19 Pandemic

Learning from the COVID-19 Pandemic PDF

Author: RC Sobti

Publisher: CRC Press

Published: 2023-08-24

Total Pages: 398

ISBN-13: 1000843270

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COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts on gut biota have also been noticed. The virus has caused both morbidity and mortality in humans without any geographical, cultural, or religious barriers. The emergence of new variants due to mutations in the virus has aggravated the problem. While the delta variant brought a second wave and killed a large number of people due to various factors such as lowering of saturated oxygen in blood and other physiological emergencies, the omicron variant proved to be less lethal. Though the pandemic has subsided, the emergence of the subvariants BA1 and BA2 and now their hybrids has started to increase the number of cases at exponential levels and has forced new lockdown measures in places such as China. As the conditions laid down to combat the pandemic have been relaxed, the virus may reach other countries and cause additional countries to resort to lockdown again. COVID-19 became the focus of the scientific community with the aim of developing new drugs, repurposing available drugs to be used against the virus, and developing a series of vaccines in a short time. The mild effect of omicron might have been due to the extensive vaccination programmes carried out in various countries. However, there is genuine fear that newly emerging variants may evade the immune system and cause damage to the body. This book highlights the impact of COVID-19 on science, industry, and healthcare systems. The chapters included in the volume come from dedicated experts belonging to basic sciences, biotechnology, pharmaceutical sciences, and other fields of sciences. These include discussions on how the virus evolves and attacks various organs in the body. A separate chapter explains the emergence of various strains of virus. The preparedness of hospitals and healthcare workers as well as different agencies such as DRDO to face the challenges posed by virus is also discussed. The way scientists and technologists developed new techniques to detect and control the virus have also been highlighted including a chapter on the development of vaccines to control the pandemic. This book is a key resource for students, teachers, medical personnel, administrators, and the public as a whole.

INDIA 2022

INDIA 2022 PDF

Author: Publications Division

Publisher: Publications Division Ministry of Information & Broadcasting

Published:

Total Pages: 1188

ISBN-13: 9354094791

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This is a Reference Annual, a yearbook carrying all the information of central government schemes, programmes and policies. Information of States and UTs is also included in the Reference Book.

The Absolutely True Diary of a Part-Time Indian

The Absolutely True Diary of a Part-Time Indian PDF

Author: Sherman Alexie

Publisher: Random House

Published: 2016-09-15

Total Pages: 273

ISBN-13: 1448188563

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An all-new edition of the tragicomic smash hit which stormed the New York Times bestseller charts, now featuring an introduction from Markus Zusak. In his first book for young adults, Sherman Alexie tells the story of Junior, a budding cartoonist who leaves his school on the Spokane Indian Reservation to attend an all-white high school. This heartbreaking, funny, and beautifully written tale, featuring poignant drawings that reflect the character's art, is based on the author's own experiences. It chronicles contemporary adolescence as seen through the eyes of one Native American boy. 'Excellent in every way' Neil Gaiman Illustrated in a contemporary cartoon style by Ellen Forney.

The Adenoviruses

The Adenoviruses PDF

Author: Harold S. Ginsberg

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 620

ISBN-13: 1468479350

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The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .

Coronavirus (COVID-19) Outbreaks, Environment and Human Behaviour

Coronavirus (COVID-19) Outbreaks, Environment and Human Behaviour PDF

Author: Rais Akhtar

Publisher: Springer Nature

Published: 2021-04-22

Total Pages: 483

ISBN-13: 3030681203

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This book covers over 24 country studies on various dimensions associated with the geographical spread of COVID-19. The chapters in the book, from geographically diversified countries, assert the need to undertake intensive regional research in order to understand the global pattern of Coronavirus focusing on infection migration, and indigenous origin that has caused tremendous global economic, social and health disaster. The book contends that understanding of peoples’ behaviour is crucial towards safety measures against infection, as COVID-19 impacted to a greater extent social wellbeing of population because of lockdowns in all corners of the world. Some of the countries featured are USA, France, Italy, Hong Kong, South Korea, Canada, Australia, Pacific Islands, Russia, Taiwan, Thailand, Malaysia, Indonesia, India, South Africa, Nigeria, Mexico, Peru and Brazil.

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy PDF

Author: David T. Curiel

Publisher: Academic Press

Published: 2016-03-10

Total Pages: 868

ISBN-13: 0128005106

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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials