How Do Metabolism, Angiogenesis, and Hypoxia Modulate Resistance?
Author: Matilde Esther LLeonart
Publisher: Frontiers Media SA
Published: 2021-05-25
Total Pages: 175
ISBN-13: 2889668010
DOWNLOAD EBOOK →Lanterna Rally
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Biomarkers in Breast Cancer
Author: Giampietro Gasparini
Publisher: Springer Science & Business Media
Published: 2008-01-17
Total Pages: 335
ISBN-13: 159259915X
DOWNLOAD EBOOK →Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
The Heterogeneity of Cancer Metabolism
Author: Anne Le
Publisher: Springer
Published: 2018-06-26
Total Pages: 186
ISBN-13: 331977736X
DOWNLOAD EBOOK →Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Hypoxia and Cancer Metastasis
Author: Daniele M. Gilkes
Publisher: Springer
Published: 2019-06-14
Total Pages: 160
ISBN-13: 3030127346
DOWNLOAD EBOOK →The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.
Angiogenesis in Adipose Tissue
Author: Yihai Cao
Publisher: Springer Science & Business Media
Published: 2013-09-05
Total Pages: 374
ISBN-13: 1461480698
DOWNLOAD EBOOK →Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
Physiologic and Pathologic Angiogenesis
Author: Dan Simionescu
Publisher: BoD – Books on Demand
Published: 2017-04-05
Total Pages: 466
ISBN-13: 9535130234
DOWNLOAD EBOOK →The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Tumor Progression and Metastasis
Author: Ahmed Lasfar
Publisher:
Published: 2020
Total Pages:
ISBN-13: 9781789851465
DOWNLOAD EBOOK →Tumor Oxygenation
Author: Peter Vaupel
Publisher: Lubrecht & Cramer, Limited
Published: 1995
Total Pages: 348
ISBN-13:
DOWNLOAD EBOOK →Metabolism in Cancer
Author: Thorsten Cramer
Publisher: Springer
Published: 2016-08-24
Total Pages: 272
ISBN-13: 3319421182
DOWNLOAD EBOOK →This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Oxygen Sensing
Author:
Publisher: Elsevier
Published: 2004-05-10
Total Pages: 867
ISBN-13: 0080497195
DOWNLOAD EBOOK →The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.
