Hormone Receptors in Breast Cancer

Hormone Receptors in Breast Cancer PDF

Author: Suzanne A. W. Fuqua

Publisher: Springer Science & Business Media

Published: 2008-12-10

Total Pages: 289

ISBN-13: 0387094636

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Clinical Interest of Steroid Hormone Receptors in Breast Cancer

Clinical Interest of Steroid Hormone Receptors in Breast Cancer PDF

Author: G. Leclercq

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 381

ISBN-13: 364282188X

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Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a register of the european centers performing receptor assays. It has been our purpose to fill these gaps. A large majority of authors who we contacted kindly agreed to con tribute to our book. Papers were grouped into six main parts according to their contents. The abundance of clinical data relevant to receptor assays led us to add critical summaries to help the reader to form his own opinions on the subject. We would like to thank Drs. R. J. B. King, G. Contesso, L. Santi, and E. Engelsman, who helped us in this regard. We hope that this book will enable the reader to become acquainted with the present state of European steroid hormone receptor studies devoted to breast cancer treatment. We also hope that it will promote cooperation between European oncologists involved in this field of research.

Hormone Receptors in Breast Cancer

Hormone Receptors in Breast Cancer PDF

Author: Suzanne A. W. Fuqua

Publisher: Springer

Published: 2008-11-01

Total Pages: 0

ISBN-13: 9780387560380

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Hormone Receptors in Breast Cancer

Hormone Receptors in Breast Cancer PDF

Author: Suzanne A. W. Fuqua

Publisher: Springer

Published: 2014-10-20

Total Pages: 0

ISBN-13: 9781489996800

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Hormonal Carcinogenesis V

Hormonal Carcinogenesis V PDF

Author: Jonathan J. Li

Publisher: Springer Science & Business Media

Published: 2008-04-24

Total Pages: 647

ISBN-13: 0387690808

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Information gathered from cell-free systems, cell cultures, animal models, and human studies, together provide important insights to our understanding of hormonal cancer causation, development, and prevention; the primary objective of these Symposia. A special emphasis is placed on the two major endocrine-related cancers, that is, breast and prostate. The emerging fields of colon, lung, and pancreatic cancers in relation to hormones are examined.

Estrogens, Estrogen Receptor and Breast Cancer

Estrogens, Estrogen Receptor and Breast Cancer PDF

Author: Fritz F. Parl

Publisher: IOS Press

Published: 2000

Total Pages: 280

ISBN-13: 9780967335544

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Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.

Hormone Receptors in Breast Cancer Prognosis - Racial and Quantitative Effects

Hormone Receptors in Breast Cancer Prognosis - Racial and Quantitative Effects PDF

Author:

Publisher:

Published: 2001

Total Pages: 0

ISBN-13:

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Breast cancer survivors compose the largest group of cancer survivors in the United States. As heterogeneity exists within stages and between races in breast cancer survival, it is important to develop a better understanding of prognostic factors. Tumor estrogen and progesterone receptors are one of the more important prognostic factors in breast cancer patients. However, currently in clinical practice hormone receptor status is treated as either being present or absent and is treated similarly in all groups. The dichotomization of hormone status may lead to loss of valuable information and hormone receptor status may not have the same effect in African Americans and Whites. This historical cohort study evaluates quantitative differences in tumor hormone receptors in African Americans and Whites and determines whether survival effects differ between the two groups. This study also assesses whether a dose-response relationship, linear or nonlinear, exists between hormone receptors and survival. Findings of this study may lead to better prediction of survival and to identification of subsets of patients at higher risk that may have gone unrecognized by the application of a single cutpoint. Our preliminary findings indicate that African American breast cancer patients have more estrogen receptor negativity and a worse survival.

Sex Hormone Receptor Signals in Human Malignancies

Sex Hormone Receptor Signals in Human Malignancies PDF

Author: Hiroshi Miyamoto

Publisher: MDPI

Published: 2019-10-01

Total Pages: 150

ISBN-13: 3039211730

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Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors. Meanwhile, emerging evidence has indicated that sex hormone receptor signals are involved in the outgrowth of some malignancies, such as prostate and breast carcinomas, as well as others that have not traditionally been considered as endocrine-related neoplasms. This Special Issue “Sex Hormone Receptor Signals in Human Malignancies” covers various aspects of the potential role of sex hormone receptors and related signals in prostate cancer, breast cancer, and other neoplastic conditions by depicting promising findings derived from in vitro and in vivo experiments as well as the analyses of surgical specimens. The current observations described may thus provide a unique insight into novel or known functions of sex hormone receptors and related molecules.

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