Hibernation and the Hypothalamus

Hibernation and the Hypothalamus PDF

Author: Nicholas Mrosovsky

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 296

ISBN-13: 1468471767

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Mammalian hibernation is commonly thought of as something completely out of the ordinary, a "unique and unorthodox state." The present book takes the opposite view. It argues that the physiological achievements of hibernators do not deEend on special mechanisms but on special use of ordinary mechanisms. It is precisely this that makes the hibernators important. If the hibernators de pend on some unique physiological principle their study is that of a biological curio. But if they are using basic mammalian systems in a quantitatively extreme way, then they are a naturally occurring preparation of enormous potential. Hibernation involves every aspect of the animal's biology from fat metabo lism to behavior, from thermoregulation to dental caries; every system in the body is affected in some way or other by hibernation. A comprehensive account of hibernation would be almost coextensive with an account of the whole of mammalian biology. The present book does not attempt to describe everything that has been discovered about hibernation. Excellent coverage for that already exists in the proceedings of three recent symposia and in the other major source materials listed on page 233. There is in fact an enormous amount of information already available. But there is a difference between information and understanding. Despite the increasing volume of research and growing interest in mammalian hibernation, there is little appreciation of the essential characteristics of the phenomena. The pieces of the puzzle lie scattered.

Hibernation and Torpor in Mammals and Birds

Hibernation and Torpor in Mammals and Birds PDF

Author: Charles P Lyman

Publisher: Elsevier

Published: 2013-07-10

Total Pages: 332

ISBN-13: 0323138241

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Hibernation and Torpor in Mammals and Birds explores the physiological factors that control hibernation and torpor in birds and mammals. This text covers topics ranging from metabolism in hibernation to the role of endocrines, respiration and acid-base state in hibernation, and theories of hibernation. This book is comprised of 14 chapters and begins with an overview of some clear-cut definitions and why mammals and birds hibernate. The reader is then introduced to the variations from euthermia that have been observed among birds and mammals. To give some structure to this listing, the approach is phylogenetic, starting with the birds and proceeding through the primitive to the more advanced mammals. Subsequent chapters explains the process of entering hibernation and the hibernating state, itself; capability of a species in natural hibernation to arouse from that state using self-generated heat; physiological changes at the start of a spontaneous arousal; and physiological mechanisms underlying the ability of hibernators to rewarm. Consideration is also given to intermediary metabolism in hibernation, cold adaptation of metabolism in hibernators, and the response of hibernators to various extrinsic influences such as neoplastic growth, radiation injury, and parasitism and symbionts. This book will be of interest to students and researchers in fields ranging from zoology to physiology and biophysics.

The Orexin System. Basic Science and Role in Sleep Pathology

The Orexin System. Basic Science and Role in Sleep Pathology PDF

Author: M.A. Steiner

Publisher: Karger Medical and Scientific Publishers

Published: 2021-05-28

Total Pages: 165

ISBN-13: 3318068446

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The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Micro-, Meso- and Macro-Dynamics of the Brain

Micro-, Meso- and Macro-Dynamics of the Brain PDF

Author: György Buzsáki

Publisher: Springer

Published: 2016-05-02

Total Pages: 181

ISBN-13: 3319288024

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This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Hunger, Thirst, Sex, and Sleep

Hunger, Thirst, Sex, and Sleep PDF

Author: John K. Young

Publisher: Rowman & Littlefield Publishers

Published: 2012-08-09

Total Pages: 178

ISBN-13: 1442218258

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Sensations of hunger, thirst, sexual attraction, and love can dominate our thoughts to the exclusion of almost everything else, but until the last 10 years or so, the precise reasons why these passions arise have not been understood very well. We now know that these, and other drives like the urge to sleep, are controlled by a small portion of the brain called the hypothalamus. This book presents the latest information about how the brain controls our most basic drives. In a series of fascinating anecdotes, Young tells the tale of how scientists have discovered the role of the hypothalamus in our basic drives and in medical conditions in which these drives are drastically altered. Covering our need for food, water, sex, sleep, and other life essentials, he reveals the brain’s part in how we provide for each, and how in some cases, those needs can swing wildly out of control resulting in problems such as obesity, diabetes, insomnia, or narcolepsy. He shows how regulating body temperature can affect the lifespan, how the aging process affects sexual behavior, how empathy and love develop in relationships with family members or with love interests, and how all these functions and more can go awry. Like other science writers before him, Young illuminates even the complex inner workings of the brain in a way that anyone can understand, so that readers are treated to a tour of a tiny part of the brain that is responsible for so many fundamental aspects of life.

Torpor and Hibernation: Metabolic and Physiological Paradigms

Torpor and Hibernation: Metabolic and Physiological Paradigms PDF

Author: Sylvain Giroud

Publisher: Frontiers Media SA

Published: 2024-06-21

Total Pages: 138

ISBN-13: 2832550622

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Torpor or heterothermy corresponds to a state of depressed metabolism and is associated with specific metabolic, cellular and molecular adaptations that often occur on a seasonal basis. Yet the exact mechanisms and functioning of these changes are poorly understood. Interestingly, the potential of such extraordinary animal adaptation for human and animal health as well as other biomedical considerations has raised particular attention especially in the last decade. The strong metabolic and physiological adaptations of heterotherms can be of particular inspiration for current biomedical and pathological situations (e.g., obesity and related diseases, cardiovascular and metabolic dysfunctions, ischemia-reperfusion injuries, immune depression) and for the health and longevity of animal species, including humans.

The Hypothalamus-Pituitary-Adrenal Axis

The Hypothalamus-Pituitary-Adrenal Axis PDF

Author:

Publisher: Elsevier

Published: 2008-09-12

Total Pages: 416

ISBN-13: 9780080559360

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The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. * Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle. * Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later.

Zen and the Brain

Zen and the Brain PDF

Author: James H. Austin

Publisher: MIT Press

Published: 1999-06-04

Total Pages: 876

ISBN-13: 9780262260350

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A neuroscientist and Zen practitioner interweaves the latest research on the brain with his personal narrative of Zen. Aldous Huxley called humankind's basic trend toward spiritual growth the "perennial philosophy." In the view of James Austin, the trend implies a "perennial psychophysiology"—because awakening, or enlightenment, occurs only when the human brain undergoes substantial changes. What are the peak experiences of enlightenment? How could these states profoundly enhance, and yet simplify, the workings of the brain? Zen and the Brain presents the latest evidence. In this book Zen Buddhism becomes the opening wedge for an extraordinarily wide-ranging exploration of consciousness. In order to understand which brain mechanisms produce Zen states, one needs some understanding of the anatomy, physiology, and chemistry of the brain. Austin, both a neurologist and a Zen practitioner, interweaves the most recent brain research with the personal narrative of his Zen experiences. The science is both inclusive and rigorous; the Zen sections are clear and evocative. Along the way, Austin examines such topics as similar states in other disciplines and religions, sleep and dreams, mental illness, consciousness-altering drugs, and the social consequences of the advanced stage of ongoing enlightenment.