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Hemopoietic System

Author: Thomas C. Jones

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 644

ISBN-13: 3642841104

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the hemopoietic system, is the eighth volume of a set prepared under the sponsorship of the International Life Sciences In stitute (ILSI).

Hematopoiesis

Author: Leonard I. Zon

Publisher: Oxford University Press

Published: 2001-04-12

Total Pages: 864

ISBN-13: 9780199771752

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Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.

Handbook of the Hemopoietic Microenvironment

Author: Mehdi Tavassoli

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 469

ISBN-13: 1461244943

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In 1868, Ernst Neumann recognized that blood cells re quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc tic lands. There the seeds may develop but they may pro duce trees no higher than our moss.

Atlas of Human Hemopoietic Development

Author: E. Kelemen

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 269

ISBN-13: 3662111934

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During the past 20 years, celJ biology has made immense strides which have completely transformed the time-honored morphological hematology of yesterday. This progress is primarily due to the introduction of new techniques which allow functional rather than anatomic studies: labeling techniques have made possible the study of celJ kinetics from birth to death of a celJ: culture techniques (both in vivo and in vitro) have made it possible to establish the progeny of certain stern celJs, their growth poten tiaL and the mechanisms of their regulation. The results have been so impressive and have so aroused the enthusiasm 01' young hematologists that it has become fashionable in so me quarters to consider the microscope an "extinct instrument" and morphology littlc more than an outmoded (if agreeable) pastime of little scientific interest. One of the consequences is the wish of some investigators to study cytology without the aid of their eyes. The present book makes us realize once more that morphology is the science of structure and shape and that its aim is not to colJect pictures but to understand them. It is true that microscopic observation, even when made with the electron microscope, cannot by itself answer some basic questions of celJ biology. However, the hematologist who uses only a single technique is like a person who would describe the world from the point of view of a single sensory organ and would refuse the aid of the others.

A Practical Guide to the Histology of the Mouse

Author: Cheryl L. Scudamore

Publisher: John Wiley & Sons

Published: 2014-02-10

Total Pages: 258

ISBN-13: 1119941202

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A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

Janeway's Immunobiology

Author: Kenneth Murphy

Publisher: Garland Science

Published: 2010-06-22

Total Pages:

ISBN-13: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Theory of Hematopoiesis Control

Author: A.M. Dygai

Publisher: Springer

Published: 2014-09-16

Total Pages: 100

ISBN-13: 3319085840

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This monograph summarizes the large amount of experimental data accumulated during many years of studying the functions of the blood system and its regulatory mechanisms under the action of diverse morbific factors within the models of pathological processes (e.g. immobilization stress, blood loss, inflammation, cytostatic and radiation myelosuppressions, experimental encephalopathies, neuroses, and spontaneous leucosis). These data are is analyzed with the understanding that hematopoietic tissue is an integrated system that can react to the challenges of both the internal and external environments. This analysis helped develop the theory of hematopoiesis control describing the regularities in the work of basic subdivisions of the hematopoietic tissue under normal and pathological conditions, as well as the performance and interaction of the local and long-ranged control systems. The monograph is recommended for Physiologists, Pathophysiologists, Hematologists, Oncologists, Pharmacologists and other professionals.

Hemopoietic Colonies

Author: D. Metcalf

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 397

ISBN-13: 364281140X

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The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro. The time seemed appropriate to write a short general account of this exciting new area of hematology, emphasizing particularly the potential value of these new techniques for direct studies on patients with leukemia and allied diseases. I had hoped to refer to, or at least record, every paper published in this field, but the literature proved to be larger than I had realized, and furthermore, some areas were so active that chapters had to be rewritten over a period of less than a year. I regret that ·what follows is an incomplete account and no doubt, by the time this book becomes available, the material will be even more out of date. However, I have described the basic techniques in some detail and have tried, where possible, to explain how and why the techniques can fail. It is already possible to see patterns, perhaps even principles, emerging from this work which may well be applicable to other cell populations. These have been emphasized in the text in an attempt to make this review as creative as possible.

Advances in Hematopoietic System Research and Application: 2011 Edition

Author:

Publisher: ScholarlyEditions

Published: 2012-01-09

Total Pages: 236

ISBN-13: 1464923779

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Advances in Hematopoietic System Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Hematopoietic System in a concise format. The editors have built Advances in Hematopoietic System Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hematopoietic System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Hematopoietic System Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hematopoietic Stem Cells

Author: Louis M. Pelus

Publisher: Springer Nature

Published: 2022-10-18

Total Pages: 284

ISBN-13: 1071626795

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This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.