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Handbook for Chemical Process Research and Development

Author: Wenyi Zhao

Publisher: CRC Press

Published: 2016-11-03

Total Pages: 1170

ISBN-13: 1315350203

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

Handbook for Chemical Process Research and Development, Second Edition

Author: Wenyi Zhao

Publisher: CRC Press

Published: 2023-03-21

Total Pages: 938

ISBN-13: 1000859053

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This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies. Features: This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner. Promotes an industrial mindset concerning safety and commercial viability when developing methods. The author discusses development strategies with case studies and experimental procedures. Focuses on mechanism-guided process development which provides readers with practical strategies and approaches. Addresses more common process issues such as safety, cost, robustness, and environmental impact. This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.

Handbook for Chemical Process Research and Development

Author: Wenyi Zhao (Chemist)

Publisher:

Published: 2023

Total Pages: 0

ISBN-13: 9781032264615

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"This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies"--

Handbook of Chemical Process Development

Author: S. B. Chandalia

Publisher:

Published: 2002

Total Pages: 310

ISBN-13: 9788187070146

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Handbook for Chemical Process Industries

Author: Himanshu J Patel

Publisher: CRC Press

Published: 2023-10-06

Total Pages: 572

ISBN-13: 1000969673

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Chemical processing industry plays a pivotal role in the economy of a country, as chemicals are required in every sphere of our lives. This book covers chemical processing of dyes, pigments, drugs and pharmaceutical products, fermented products, agrochemicals, explosives, polymers, Period II and III chemicals, chemicals, sugar, coatings, starches, soaps and detergents, paper, pulp, glass, and cement. It includes sources of natural materials, collection process, purification, and extraction of different chemicals from natural materials like petroleum, coal and ores from the Earth. It includes manufacturing details of C1 to C4 and aromatic compounds obtained from natural materials. The book covers both traditional and modern sectors of the chemical processing industry. It provides knowledge on the properties of the chemical and manufacturing process (such as raw materials, chemical reactions, quantitative requirement, flow sheet diagram, procedure) and its uses. The book is based on the author's expertise and has been developed with an awareness of the quantitative requirement for manufacturing chemicals. Data has been collected from industry, thus it will be useful to industry personnel, research groups, academicians and institutional organizations.

Practical Process Research & Development

Author: Neal G. Anderson

Publisher: Academic Press

Published: 2000-03

Total Pages: 354

ISBN-13: 9781483299778

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes

The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry

Author: Someswara Rao

Publisher: John Wiley & Sons

Published: 2007-04-02

Total Pages: 1

ISBN-13: 047031995X

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This book brings together the chemical strategies used in the optimisation of organic reactions and processes, and highlights the practical and technological options available. This book offers: an encyclopedic treatment of organic chemistry from an industrial, process research and development, and manufacturing point of view plenty of examples to illustrate the scope and limitation of the strategies a comprehensive index organised by topic, reaction type, and reagent an extensive literature survey. This is an essential and comprehensive guide for experienced practitioners of chemical process research and development, fresh recruits to chemical industry R&D divisions, and academics who are interested in interacting with the chemical industry, optimising their synthetic strategies, and enriching the field of atom economy.

Perry's Chemical Engineers' Handbook, 9th Edition

Author: Don W. Green

Publisher: McGraw Hill Professional

Published: 2018-07-13

Total Pages: 2274

ISBN-13: 0071834095

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Up-to-Date Coverage of All Chemical Engineering Topics―from the Fundamentals to the State of the Art Now in its 85th Anniversary Edition, this industry-standard resource has equipped generations of engineers and chemists with vital information, data, and insights. Thoroughly revised to reflect the latest technological advances and processes, Perry's Chemical Engineers' Handbook, Ninth Edition, provides unsurpassed coverage of every aspect of chemical engineering. You will get comprehensive details on chemical processes, reactor modeling, biological processes, biochemical and membrane separation, process and chemical plant safety, and much more. This fully updated edition covers: Unit Conversion Factors and Symbols • Physical and Chemical Data including Prediction and Correlation of Physical Properties • Mathematics including Differential and Integral Calculus, Statistics , Optimization • Thermodynamics • Heat and Mass Transfer • Fluid and Particle Dynamics *Reaction Kinetics • Process Control and Instrumentation• Process Economics • Transport and Storage of Fluids • Heat Transfer Operations and Equipment • Psychrometry, Evaporative Cooling, and Solids Drying • Distillation • Gas Absorption and Gas-Liquid System Design • Liquid-Liquid Extraction Operations and Equipment • Adsorption and Ion Exchange • Gas-Solid Operations and Equipment • Liquid-Solid Operations and Equipment • Solid-Solid Operations and Equipment •Chemical Reactors • Bio-based Reactions and Processing • Waste Management including Air ,Wastewater and Solid Waste Management* Process Safety including Inherently Safer Design • Energy Resources, Conversion and Utilization* Materials of Construction

Handbook of Industrial Hydrocarbon Processes

Author: James G. Speight

Publisher: Gulf Professional Publishing

Published: 2010-12-24

Total Pages: 602

ISBN-13: 9780080942711

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Written by an author with over 38 years of experience in the chemical and petrochemical process industry, this handbook will present an analysis of the process steps used to produce industrial hydrocarbons from various raw materials. It is the first book to offer a thorough analysis of external factors effecting production such as: cost, availability and environmental legislation. An A-Z list of raw materials and their properties are presented along with a commentary regarding their cost and availability. Specific processing operations described in the book include: distillation, thermal cracking and coking, catalytic methods, hydroprocesses, thermal and catalytic reforming, isomerization, alkylation processes, polymerization processes, solvent processes, water removal, fractionation and acid gas removal. Flow diagrams and descriptions of more than 250 leading-edge process technologies An analysis of chemical reactions and process steps that are required to produce chemicals from various raw materials Properties, availability and environmental impact of various raw materials used in hydrocarbon processing

Chemical Engineering Design

Author: Gavin Towler

Publisher: Elsevier

Published: 2012-01-25

Total Pages: 1321

ISBN-13: 0080966608

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Chemical Engineering Design, Second Edition, deals with the application of chemical engineering principles to the design of chemical processes and equipment. Revised throughout, this edition has been specifically developed for the U.S. market. It provides the latest US codes and standards, including API, ASME and ISA design codes and ANSI standards. It contains new discussions of conceptual plant design, flowsheet development, and revamp design; extended coverage of capital cost estimation, process costing, and economics; and new chapters on equipment selection, reactor design, and solids handling processes. A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data, and Excel spreadsheet calculations, plus over 150 Patent References for downloading from the companion website. Extensive instructor resources, including 1170 lecture slides and a fully worked solutions manual are available to adopting instructors. This text is designed for chemical and biochemical engineering students (senior undergraduate year, plus appropriate for capstone design courses where taken, plus graduates) and lecturers/tutors, and professionals in industry (chemical process, biochemical, pharmaceutical, petrochemical sectors). New to this edition: Revised organization into Part I: Process Design, and Part II: Plant Design. The broad themes of Part I are flowsheet development, economic analysis, safety and environmental impact and optimization. Part II contains chapters on equipment design and selection that can be used as supplements to a lecture course or as essential references for students or practicing engineers working on design projects. New discussion of conceptual plant design, flowsheet development and revamp design Significantly increased coverage of capital cost estimation, process costing and economics New chapters on equipment selection, reactor design and solids handling processes New sections on fermentation, adsorption, membrane separations, ion exchange and chromatography Increased coverage of batch processing, food, pharmaceutical and biological processes All equipment chapters in Part II revised and updated with current information Updated throughout for latest US codes and standards, including API, ASME and ISA design codes and ANSI standards Additional worked examples and homework problems The most complete and up to date coverage of equipment selection 108 realistic commercial design projects from diverse industries A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data and Excel spreadsheet calculations plus over 150 Patent References, for downloading from the companion website Extensive instructor resources: 1170 lecture slides plus fully worked solutions manual available to adopting instructors