-PDF Download- Genetics Of Asthma And Chronic Obstructive Pulmonary Disease EBOOK

Genetics of Asthma and Chronic Obstructive Pulmonary Disease

Author: Dirkje S. Postma

Publisher: CRC Press

Published: 2007

Total Pages: 456

ISBN-13:

Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.

Candidate Gene Association Studies of Chronic Obstructive Pulmonary Disease and Asthma

Author:

Publisher:

Published: 2004

Total Pages:

ISBN-13:

DOWNLOAD EBOOK →

COPD and asthma are complex diseases characterized by pulmonary inflammation. The roles of single nucleotide polymorphisms (SNPs) in the inflammatory cytokine IL10, IL10RA, CSF2, CSF3 and IL6 in COPD and SNPs in a Th2-polarizing cytokine thymic stromal lymphopoietin (TSLP) in asthma are not clear. Association studies were performed to explore the genetic contribution of these cytokines to COPD or asthma. Housekeeping genes on airway epithelium were also optimized. In the study of COPD in the Lung Health Study (LHS), no association was found for IL10, IL10RA and CSF2; an increase in the number of CSF3 -1719T alleles was associated with protection against low forced expiratory volume in one second (FEV1), odds ratio (OR) = .73, 95% confidence interval (CI) = .56 - .95, P = .018; three IL6 SNPs were associated with the rate of decline of FEV1 (.023 d"P d".041 in additive models). In the National Emphysema Treatment Trial - Normative Aging Study, IL6_-174G/C and four other highly linked SNPs were associated with COPD (.01 d"P d".04 in additive genetic models). Association between IL6 and rate of FEV1 decline was the most statistically significant observations in all of our studies in LHS, which has examined more than 40 candidate genes. In the study of TSLP association with asthma, the A allele of rs1837253 was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness (AHR), with ORs (95% CI) and corrected P values for each being .79 (.69 - .90) and .0058; .75 (.63 - .88) and .0074; and .76 (.64 - .89) and .0094, respectively. These associations were the most statistically significant observations in our study, which has examined 98 candidate genes. Cyclophilin A was identified as the most suitable normalizer in gene expression studies involving human airway epithelium. In summary, we demonstrate for the first time that IL6 SNPs are associated with rapid decline of FEV1 and COPD; TSLP SNPs are associated with asthma and AHR. These results wil.

Respiratory Genetics

Author: Edwin Silverman

Publisher: CRC Press

Published: 2005-09-30

Total Pages: 555

ISBN-13: 0340814322

DOWNLOAD EBOOK →

There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

Asthma and COPD

Author: Peter J. Barnes

Publisher: Elsevier

Published: 2009-03-19

Total Pages: 897

ISBN-13: 0080920608

DOWNLOAD EBOOK →

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

Asthma, COPD, and Overlap

Author: Jonathan A. Bernstein

Publisher: CRC Press

Published: 2018-03-22

Total Pages: 290

ISBN-13: 0429765185

DOWNLOAD EBOOK →

Using illustrative case examples, this book thoroughly reviews similarities and differences between asthma, chronic obstructive pulmonary disease (COPD) and the overlap syndrome. It is important to highlight the distinctions because these commonly encountered conditions in respiratory and primary care share many similarities but have important differences often mistaken for each other. This can have serious implications for treatment, particularly as new treatments are targeted at specific phenotypes of the diseases. This practical guide shows how to distinguish between the diseases on a pathological and clinical basis so that appropriate management and treatment may be pursued.

Genetic Determinants of Pulmonary Disease

Author: Stephen. D. Litwin

Publisher: CRC Press

Published: 2020-08-13

Total Pages: 305

ISBN-13: 1000110443

DOWNLOAD EBOOK →

This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.

Medical Genetics of Asthma

Author: Garden Grove Garden Grove Press

Publisher:

Published: 2017-04-05

Total Pages: 188

ISBN-13: 9781545180945

DOWNLOAD EBOOK →

This article collection reviews the medical genetics of asthma and includes 22 papers by various authors. Topics include: Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population; Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population; Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes; A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population; Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population; Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population; A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS); Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene; Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study; Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease; Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers; Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors; Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1; Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes; Leukotriene B4 receptor locus gene characterisation and association studies in asthma; Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population; Investigating highly replicated asthma genes as candidate genes for allergic rhinitis; Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis; The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study; Genome-wide association study identifies PERLD1 as asthma candidate gene; Large scale genotyping study for asthma in the Japanese population; ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. Proceeds from the sale of this book go to the support of an elderly disabled person.

Bronchial Vascular Remodeling in Asthma and COPD

Author: Aili Lazaar

Publisher: CRC Press

Published: 2006-08-04

Total Pages: 264

ISBN-13: 1420018450

DOWNLOAD EBOOK →

Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes t

Bronchial Asthma

Author: Denis Leigh

Publisher: Elsevier

Published: 2016-10-27

Total Pages: 211

ISBN-13: 1483155889

DOWNLOAD EBOOK →

Bronchial Asthma: A Genetic, Population and Psychiatric Study presents the main theories of the cause of asthma which states that attacks occurred as a result of pathological changes in the lungs, heart, or large vessels. It discusses that spasms and paralysis of the bronchi were produced by nervous or humoral changes, or from bronchial exudation. Organized into 15 chapters, this book starts with an overview of the relationships between bronchial asthma and several conditions commonly regarded as allergic in nature, including hay fever, eczema, vasomotor rhinitis, urticarial, gastro-intestinal allergy, and psoriasis. This text then discusses the Weinberg genealogical proband method. Other chapters explore the inherited susceptibility of the bronchial tree to dysfunction, be it inflammation, as with bronchitis, or spasm, as with asthma. The final chapter deals with the inquiry using the Weinberg genealogical proband technique into the genetics of bronchial asthma. This book is a valuable resource for physicians, dermatologists, and allergists.

Pharmacology and Therapeutics of Asthma and COPD

Author: Clive P. Page

Publisher: Springer Science & Business Media

Published: 2004-01-07

Total Pages: 396

ISBN-13: 9783540004646

DOWNLOAD EBOOK →

The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.