Genetic Effects on Aging

Genetic Effects on Aging PDF

Author: David E. Harrison

Publisher: CRC Press

Published: 1990-08-09

Total Pages: 612

ISBN-13: 9780936923314

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This volume provides background knowledge useful to those setting out to do genetic studies of aging in mammals, and raises vital questions: How many genes are important in mammalian aging? What are the optimal methods for their study? To what degree are patterns of aging, and patterns of growth and development part of the same process? Do patterns of development predict subsequent patterns of growth and aging? Are there a few fundamental aging processes, or does every biological system age? The rapid rate of progress in this field required a new volume with a new approach, based on the combination of classical genetics and the powerful new tools of molecular genetics. Although mammalian systems are emphasized, representatives of the advanced genetic studies in Drosophila and other model systems are included. The purpose is to enrich and stimulate genetic studies of mammalian aging by suggesting and evaluating future possibilities.

Epigenetics of Aging

Epigenetics of Aging PDF

Author: Trygve O. Tollefsbol

Publisher: Springer Science & Business Media

Published: 2009-11-11

Total Pages: 462

ISBN-13: 1441906398

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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Senescence

Senescence PDF

Author: Jolanta Dorszewska

Publisher: BoD – Books on Demand

Published: 2017-08-30

Total Pages: 167

ISBN-13: 9535134612

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In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Longevity Genes

Longevity Genes PDF

Author: Gil Atzmon, PhD

Publisher: Springer

Published: 2015-04-27

Total Pages: 199

ISBN-13: 1493924044

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The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Aging

Aging PDF

Author: Cindy S. Bergeman

Publisher: SAGE

Published: 1997-04-30

Total Pages: 161

ISBN-13: 0803973780

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Why do people age differently? Research in the field of gerontology has indicated that there are large individual differences in personality, cognitive functioning, physical health, and psychological well-being, as well as in the quality of life in the later years. It is this variability and the reasons why people age differently that this book explores. Thoughtfully written, Aging presents an overview of what is known about genetic and environmental influences on aging. Beginning with an overview of family, adoption, and twin designs, author Cindy S. Bergeman examines such topics as the research in the area of longevity and health, cognitive functioning, personality, and psychopathology; and social support, life events, and measures of the family environment. The book concludes with a summary of the field of gerontological behavioral genetics. This book will stimulate discussion and future work about the origins of individual differences in later life and will be invaluable to professionals and practitioners in the fields of developmental psychology, psychology, aging, family studies, and nursing.

Genes, Aging, and Immortality

Genes, Aging, and Immortality PDF

Author: Charlotte Spencer

Publisher: Pearson

Published: 2006

Total Pages: 68

ISBN-13:

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This booklet answers questions about the mysteries of aging and the search for immortality. It describes some of the current progress in the scientific study of aging and explores social and ethical questions surrounding the real possibility of human lifespan extension.

The Biology of Senescence

The Biology of Senescence PDF

Author: Alex 1920- Comfort

Publisher: Hassell Street Press

Published: 2021-09-09

Total Pages: 282

ISBN-13: 9781014542403

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This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

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