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Genetic Disorders Among Arab Populations

Author: Ahmad S. Teebi

Publisher: Springer Science & Business Media

Published: 2010-07-30

Total Pages: 776

ISBN-13: 3642050808

Arab populations have their “own” genetic disorders, both universal and particular. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of homozygosity gene mapping can facilitate the discovery of the corresponding genes. The present book includes 5 parts dealing with various aspects that relate to the genetic structure of Arabs and minorities within the Arab world as well as genetic disorders prevalent in this part of the world. It includes updated reviews of the genetic disorders in various Arab countries and geographic regions. The focus is primarily, but not exclusively, on the group of single-gene disorders with particular emphasis on autosomal recessive conditions. It further includes epidemiological and clinical data as well as inheritance patterns, mutation and polymorphism data, and available haplotype analysis data. The ethnic and genetic diversity of the Arab populations is discussed as well as aspects of genetic counseling practice in this region together with a proposal for an ethical framework for genetic research and prevention of genetic disorders. The target audience of this book includes human and medical geneticists, genetic counselors, researchers, medical specialists dealing with Arab patients or practicing in Arab countries, medical and genetic counseling students, and nurses.

Arab Genetic Disorders

Author: Ernest L. Abel

Publisher: McFarland

Published: 2003-01-01

Total Pages: 174

ISBN-13: 9780786414635

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Certain disorders tend to occur in some ethnic groups more than others. In 2001, McFarland published the author's Jewish Genetic Disorders (superb guide...outstanding writing and well-organized text...current and comprehensive...exceptional--Library Journal). This new work covers genetic disorders that have been noted to occur with relatively high frequency in Arab populations or that are unique to them. It begins with a discussion of the basic facts about genetics and genetic diseases, and who the Arab people are and why certain genetic disorders are more common in this population. The genetic disorders are then categorized as follows: blood, cardiovascular, central nervous system, connective tissue, endocrine system, metabolic, neuromuscular, respiratory, sensory, skeletal, and skin. For each category, the disorders are examined in terms of symptoms, frequency, cause, the occasional Faustian Bargain, diagnosis, transmission, treatment, and prevention. References for more information are also provided. The book concludes with information on genetic counseling for Arab-Americans.

Genomics and Health in the Developing World

Author: Dhavendra Kumar

Publisher: Oxford University Press

Published: 2012-05-11

Total Pages: 1569

ISBN-13: 019970547X

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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address: - Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent - The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide - Rising ethical and legal concerns of medical genetics in the developing world - Social, cultural, and religious issues related to genetic diseases across continents Both timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.

The Genetics of African Populations in Health and Disease

Author: Muntaser E. Ibrahim

Publisher: Cambridge University Press

Published: 2019-12-19

Total Pages: 351

ISBN-13: 1107072026

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A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Contemporary Bioethics

Author: Mohammed Ali Al-Bar

Publisher: Springer

Published: 2015-05-27

Total Pages: 267

ISBN-13: 3319184288

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This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved.

Vogel and Motulsky's Human Genetics

Author: Michael Speicher

Publisher: Springer Science & Business Media

Published: 2009-11-26

Total Pages: 1006

ISBN-13: 3540376542

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The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the "molecular revolution" - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour. For graduates and those already working in medical genetics.

Community Genetics in the Arabian Gulf Region

Author: Lihadh Gazali

Publisher: S. Karger AG (Switzerland)

Published: 2005

Total Pages: 0

ISBN-13: 9783805578554

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Developed from the International Genetics Congress in Dubai in December 2003, this publication discusses genetic-related topics with the aim of improving the standards in education, service and research. Special focus is given to various aspects of genetic disorders from a global perspective, and on the link between basic scientific research and clinical genetics as a bridge to community health. The contributions discuss common genetic problems in Arab countries and the Middle East, and the development of preventive strategies in this region. Consanguineous marriage is common in the Arab world. This has significant implications for increased rates of recessive disorders, lethal malformations and other disease conditions. A better understanding of the influence of endogamy and consanguinity on population structure and transmission of diseases as well as the attitudes and perception of families, societies and cultural groups towards genetic disorders and genetic counselling is thus crucial in planning educational programs, genetic counselling and screening programs. This publication is of value for all those interested in clinical genetics. Readers are updated on recent developments and global challenges in their specialist field.

Consanguinity in Context

Author: Alan H. Bittles

Publisher: Cambridge University Press

Published: 2012-05-24

Total Pages: 325

ISBN-13: 1107376939

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An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of intra-familial marriage. Detailed information on past and present religious, social and legal practices and prohibitions is presented as a backdrop to the preferences and beliefs of the 1100+ million people in consanguineous unions. Chapters on population genetics, and the role of consanguinity in reproductive behaviour and genetic variation, set the scene for critical analyses of the influence of consanguinity on health in the early years of life. The discussion on consanguinity and disorders of adulthood is the first review of its kind and is particularly relevant given the ageing of the global population. Incest is treated as a separate issue, with historical and present-day examples examined. The final three chapters deal in detail with practical issues, including genetic testing, education and counselling, national and international legislation and imperatives, and the future of consanguineous marriage worldwide.

Human Genetic Diseases

Author: Dijana Plaseska-Karanfilska

Publisher: IntechOpen

Published: 2011-10-03

Total Pages: 300

ISBN-13: 9789533079363

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The genetics science is less than 150 years old, but its accomplishments have been astonishing. Genetics has become an indispensable component of almost all research in modern biology and medicine. Human genetic variation is associated with many, if not all, human diseases and disabilities. Nowadays, studies investigating any biological process, from the molecular level to the population level, use the "genetic approach" to gain understanding of that process. This book contains many diverse chapters, dealing with human genetic diseases, methods to diagnose them, novel approaches to treat them and molecular approaches and concepts to understand them. Although this book does not give a comprehensive overview of human genetic diseases, I believe that the sixteen book chapters will be a valuable resource for researchers and students in different life and medical sciences.

Principles of Psychiatric Genetics

Author: John I. Nurnberger

Publisher: Cambridge University Press

Published: 2012-09-13

Total Pages: 415

ISBN-13: 0521896495

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A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.