Genetic Damage in Human Spermatozoa

Genetic Damage in Human Spermatozoa PDF

Author: Elisabetta Baldi

Publisher: Springer Science & Business Media

Published: 2013-08-16

Total Pages: 206

ISBN-13: 1461477832

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There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Sperm Chromatin

Sperm Chromatin PDF

Author: Armand Zini

Publisher: Springer Science & Business Media

Published: 2011-08-04

Total Pages: 515

ISBN-13: 1441968571

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Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Advances in Male Mediated Developmental Toxicity

Advances in Male Mediated Developmental Toxicity PDF

Author: Bernard Robaire

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 316

ISBN-13: 1441991905

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This volume highlights major contributions that identify new developments and directions in the field over the past decade, as well as challenges for the foreseeable future. An integration of information from laboratory and epidemiological studies, male reproduction and teratology can be found throughout the volume. The range of topics include parental legacies and genomics, lifestyle, occupational and therapeutic paternal exposures and effects; effects on the gamete-packaging of human sperm; role of DNA repair and germ cell apoptosis; stem cells, epigenetics and closing; model systems and implications to clinicians and general counselors.

Male and Sperm Factors that Maximize IVF Success

Male and Sperm Factors that Maximize IVF Success PDF

Author: John Aitken

Publisher: Cambridge University Press

Published: 2020-03-31

Total Pages:

ISBN-13: 1108809804

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Male factor infertility is receiving greater emphasis in IVF programs. This book reviews the scientific evidence for various medical, environmental and lifestyle factors that can affect male fertility, such as chromosome abnormalities, age, anti-sperm antibodies and endocrine disruptors. Part of a four-book series on improving IVF success, this volume subsequently explores a range of treatments and strategies to improve sperm quality, including FSH treatment and antioxidants. It also discusses methods to prevent male infertility from childhood through to adulthood. Concise, practical and evidence-based - and with insights from global experts in the field - this text will enable gynecologists, urologists and andrologists to make evidence-based decisions that can influence the success rate of fertilization in subsequent IVF cycles.

Male Infertility

Male Infertility PDF

Author: Sijo J. Parekattil

Publisher: Springer Nature

Published: 2020-01-24

Total Pages: 895

ISBN-13: 3030323005

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A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

A Clinician's Guide to Sperm DNA and Chromatin Damage

A Clinician's Guide to Sperm DNA and Chromatin Damage PDF

Author: Armand Zini

Publisher: Springer

Published: 2018-03-05

Total Pages: 605

ISBN-13: 3319718150

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This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

Spermatozoa

Spermatozoa PDF

Author: Rosaria Meccariello

Publisher: BoD – Books on Demand

Published: 2018-06-13

Total Pages: 251

ISBN-13: 1789231701

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Spermatozoa, the haploid male gametes, are highly specialized cells capable to fertilize eggs in order to produce diploid zygote. The biogenesis of spermatozoa requires finely modulated occurrence of mitotic, meiotic, and differentiation events. Hence, the production of high-quality spermatozoa impacts fertilization with outcomes on the health of the offspring. This book provides a comprehensive overview on the biogenesis, maturation, functions and activities of spermatozoa in both physiological conditions and infertility. Particular attention has been addressed to the impact of environment on sperm quality and to the appropriate selection of high-quality spermatozoa for in vitro fertilization. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students, and offers a better understanding of spermatozoa health and disease.

Health Effects of Exposure to Low Levels of Ionizing Radiation

Health Effects of Exposure to Low Levels of Ionizing Radiation PDF

Author: National Research Council

Publisher: National Academies

Published: 1990-02-01

Total Pages: 436

ISBN-13: 0309039959

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This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

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