Gastric Cancer Research Trends

Gastric Cancer Research Trends PDF

Author: Marilyn B. Tompkins

Publisher: Nova Publishers

Published: 2007

Total Pages: 344

ISBN-13: 9781600217258

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Stomach cancer (also called gastric cancer) is the growth of cancer cells in the lining and wall of the stomach. Stomach cancer represents roughly 2 percent (25,500) cases of all new cancer cases yearly in the United States, but it is much more common in Japan, Great Britain, South America, and Iceland. It is associated with high salt in the diet, smoking, and low intake of fruits and vegetables.Infection with H. pylori is the main risk factor in about 80 percent or more of gastric cancers. It is more common in men. A very small percentage of diffuse-type gastric cancers are thought to be genetic. Hereditary Diffuse Gastric Cancer (HDGC) has only recently been identified and research is ongoing, but genetic testing and treatment options are available for families at risk. Metastasis occurs in 80-90 percent of individuals with stomach cancer, with a five year survival rate of 75 percent in those diagnosed in early stages and less than 30 percent of those diagnosed in late stages. This book presents new and important research from around the world.

Emerging Diagnostic and Therapeutic Approaches for Gastric Cancer

Emerging Diagnostic and Therapeutic Approaches for Gastric Cancer PDF

Author: Lin Chen

Publisher: Frontiers Media SA

Published: 2020-12-31

Total Pages: 218

ISBN-13: 2889663167

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

New Trends in Gastric Cancer

New Trends in Gastric Cancer PDF

Author: P.I. Reed

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 194

ISBN-13: 9400921675

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Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery". During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and Japanese experience. Because of the poor prognosis of gastric carcinoma there is increasing pressure for early detection. Some of the problems in the early detection of gastric carcinoma are discussed together with methods of surveillance of high-risk subjects. It is generally accepted that the surgical approach to gastric carcinoma should take into account the site and extent of the lesion and there are chapters on new methods for pre and intraoperative staging of the disease which allow a more logical approach to surgery. A comparison between Japanese and Western rule and results was attempted and reasons for the differences were investigated. Since the field is still evolving not all aspects could be covered, and those angles not approached in this book will be addressed in a second International Conference to be held in Rome in June 1990.

Staging Laparoscopy

Staging Laparoscopy PDF

Author: P. Hohenberger

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 206

ISBN-13: 3642562906

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Included here is a discussion of the pathophysiological aspects and risks of laparoscopic staging (such as trocar metastases) on the basis of international experience.

Gastric Cancer In The Precision Medicine Era

Gastric Cancer In The Precision Medicine Era PDF

Author: Vincenzo Canzonieri

Publisher: Springer

Published: 2019-05-02

Total Pages: 256

ISBN-13: 3030048616

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Gastric cancer is one of the most common and potentially lethal gastrointestinal malignancy, but it is now at the forefront of modern oncology due to new discoveries. In recent years, the field of gastric cancer has been transformed by many notable developments in both the diagnostic area and the therapeutic strategies. The main aim of the text is to propose a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for oncologists, pathologists, surgeons and researchers with an interest in gastric cancer. The first chapters will review the interplay between pathogens and especially H. pylori, inflammation, genomic instability, and tumorigenesis. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspectives will be illustrated. Two specific chapters will deal with tissue and serum biomarkers with an important role in diagnosis as well as prognostic and predictive markers of response to specific therapy. A central section of the book will focus on treatment options available today for patients. Surgery is the cornerstone of treatment for gastric cancer; however, the prognosis of patients with locally advanced disease is still poor even after curative resection. Therefore, in order to improve the prognosis of patients, especially with advanced stage, a multimodal strategy is advisable and is thoroughly addressed in the appropriate section. With the advent of next-generation sequencing and new preclinical model technologies, the genomic landscape of gastric cancer has been delineated and molecular characterizations finalized to novel therapeutic targets of each molecular subtype have been identified. These advances are making it feasible to integrate clinical and phenotype-based diagnostic and therapeutic methods and are described in a dedicated section. The text will conclude with chapters focusing on the future direction of gastric cancer research in the precision medicine era: an in-depth analysis of non-coding RNAs and their role in gastric cancer, the impact of immunomodulation/immunotherapy and the perspectives of nano-medicine will be finally proposed to the audience. A brief review of the existing literature addressing the above mentioned topics will be present in each chapter. This text will serve as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Perioperative Chemotherapy

Perioperative Chemotherapy PDF

Author: U. Metzger

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 170

ISBN-13: 3642824323

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One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.

Gastric Cancer

Gastric Cancer PDF

Author: Dongfeng Tan

Publisher: Lippincott Williams & Wilkins

Published: 2011

Total Pages: 369

ISBN-13: 1608316173

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Advances in Surgical Pathology: Gastric Cancer provides a concise, updated review of the pathological characteristics of gastric cancer, with an emphasis on exploring practical issues and recent developments. The book features current and emerging concepts in the field of gastric cancer, a disease whose management requires a multidisciplinary approach in which pathology plays a key role. Its six sections cover the essential histopathology of gastric cancer as well as related topics such as imaging evaluation, molecular diagnosis, and personalized treatment, among other areas of interest. Individual chapters written by international experts in the fields of pathology, gastrointestinal medical oncology, cancer epidemiology, and gastrointestinal radiology, address the fundamental issues surrounding gastric cancer, including its epidemiology, basic diagnostic features, differential diagnoses, pitfalls and complications, and treatments. Endoscopic evaluation and histology correlation are emphasized. The screening, clinical management, and treatment of gastric cancer are summarized in related book sections. Recent findings regarding the roles of immunohistochemistry and molecular testing in the diagnosis, prognosis, and personalized treatment of gastric cancer are also reviewed. The book also includes current knowledge regarding the molecular alteration of gastric cancer carcinogenesis and its impact on patient care.

Management of Gastric Cancer

Management of Gastric Cancer PDF

Author: Paul H. Sugarbaker

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 405

ISBN-13: 1461538823

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Gastric cancer has been one of the great malignant scourges affecting man kind for as long as medical records have been kept. Until operative resection pioneered by Bilroth and others became available, no effective treatment was feasible and death from cancer was virtually inevitable. Even with resection by total gastrectomy, the chances of tumor eradication remained small. Over recent years, however, the situation has been changing. Some changes have resulted from better understanding of the disease, early detec tion, and better management techniques with applied clinical research, but the reasons for other changes are poorly understood. For example, the incidence of gastric cancer is decreasing, especially in westernized societies, where it has fallen from one of the most common cancers to no longer being in the top five causes of cancer death. Still it remains the number one killer of adult males in Japan and Korea. Whether the reduced incidence in western societies is a result of dietary changes or methods of food preservation, or some other reason, is as yet uncertain. Improvements in outcome have been reported from mass screening and early detection; more refined techniques of establishing early diagnosis, tumor type, and tumor extent; more radical surgical resection; and resection at earlier stages of disease.

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