Author: Dave Dempsey
Publisher: University of Michigan Press
Published: 2006
Total Pages: 344
ISBN-13: 9780472115457
DOWNLOAD EBOOK →The story of one of the Great Lake State's most fascinating political figures, the "gentleman governor" of Michigan
Author: Alan V. Smrcka
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 246
ISBN-13: 1592594301
DOWNLOAD EBOOK →Alan V. Smrcka presents a collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes, and for the study of G proteins interactions with effectors in intact cells. Additional methods are provided for assaying G protein coupled receptor structure, function, and localization, and for studying the physiological roles for endogenous G proteins.
Author: James Major
Publisher: Mel Bay Publications
Published: 2010-10-07
Total Pages: 49
ISBN-13: 1609741137
DOWNLOAD EBOOK →Finally! There is a definitive reference guide available for harmonicas in each and every key. This ground breaking series unlocks the musical power of the 10-hole major diatonic harmonica. One key at a time, each is designed to present detailed musical information for beginners, intermediate and advanced players who are either music readers or non-reading players. Learn the notes, intervals, bends, overbends, dyads, chords, arpeggios, modes and scales that are specific to each harmonica key. There is also a special section in each book showing other types of diatonic harmonicas and the variations unique to them like—extreme bending, low-tuned, octave and tremolo-tuned models and more.Have you ever wondered which harmonica is the best one to use when you're ready to play a tune? Have you ever sat with a lap full of harmonicas desperately trying one after another, searching for the key that has all of the right notes? the Complete 10-hole Diatonic Harmonica Series is the definitive music reference guide that resolves those dilemmas and more. the G Harmonica Book is packed with information about chords, arpeggios, modes, positions, scales, bends, overbends and basic music theory unique to the 10-hole G major diatonic harp. Learn how to effectively play blues scales in seven different keys. It's simple. If you have a G harmonica you should own the G Harmonica Book.
Author: T J Armstrong
Publisher: Memoirs Publishing
Published: 2015-11-01
Total Pages: 492
ISBN-13: 1861515391
DOWNLOAD EBOOK →Walter is a gifted young singer who leaves his home in the forests of Germany in a quest for fame and love; he embarks on a series of adventures which leads him through the haunting landscapes of twelfth-century Europe. His encounter with the mysterious Brotherhood of Watchers drives him to the crusades, into a clash with the Doge in Venice and on to the disaster of Constantinople. But there is more to Walter than he dares imagine? What are the dark forces controlling him and those he loves? The story is wrenched into the present where a sinister Oxford don dies in mysterious circumstances leaving an occult manuscript based on Walter to his assistant Ian with certain instructions. As Ian seeks to unravel these and his own life and love begin to weave into Walter’s – to whom he bears a striking resemblance – the novel’s secrets deepen. This is a powerful and compelling tale about personal and political catastrophe and the individual’s resilience in a time of uncertainty and danger. It is also a daring and brilliant contemplation of the Middle Ages and its continuing importance. Walter’s work, it appears, is not finished, nor what he learnt, nor is his music lost forever.
Author: Yakov G. Berkovich
Publisher: Walter de Gruyter GmbH & Co KG
Published: 2017-12-18
Total Pages: 623
ISBN-13: 311039054X
DOWNLOAD EBOOK →This updated edition of this classic book is devoted to ordinary representation theory and is addressed to finite group theorists intending to study and apply character theory. It contains many exercises and examples, and the list of problems contains a number of open questions.
Author: Nancy G. Slack
Publisher: Yale University Press
Published: 2010-01-01
Total Pages: 477
ISBN-13: 0300161387
DOWNLOAD EBOOK →Slack enjoyed full access to Hutchinson's archives and conducted extensive interviews both with Hutchinson himself and with his students, colleagues, and friends. She evaluates his contributions to theoretical ecology, limnology (the study of fresh-water ecosystems), biogeochemistry, population ecology, and the creation of the new fields of systems ecology and radiation ecology, and she discusses his profound influence as a mentor. The book also looks into his personal life, which included three very different wives, a refugee baby under his care during World War II, friendships with such contemporaries as Rebecca West, Margaret Mead, and Gregory Bateson, and a host of colleagues and friends on four continents. Filled with information available nowhere else, this book draws a vibrant portrait of a giant in the discipline of twentieth-century ecology who was also a man of remarkable personal appeal. --Book Jacket.
Author: Kevin R. Lynch
Publisher: John Wiley & Sons
Published: 1999-05-10
Total Pages: 246
ISBN-13: 9780471194934
DOWNLOAD EBOOK →The past decade has seen tremendous advances in the study of G protein-coupled receptors (GPCRs), including the molecular cloning and identification of more than 100 hundred GPCR genes. But while GPCRs serve as targets for more than 300 medicines in the modern pharmacopoeia, the shrinking pool of known ligands and the continuing discovery of orphan GPCR genes have underscored the need for new approaches to ligand identification. Identification and Expression of G Protein-Coupled Receptors addresses this new direction in GPCR biochemistry-offering a definitive laboratory bench manual that emphasizes expression over primary cloning strategies. In a series of expert contributions by well-known researchers, this book provides detailed protocols for various expression systems-from bacteria to mammalian cells-as well as straightforward opinions on the advantages and shortcomings of each approach. Topics covered include: * Homology screening and the polymerase chain reaction in the cloning of GPCR genes * Cloning of GPCRs using mammalian cell expression * GPCR informatics and the orphan problem * The use of Xenopus laevis oocytes for the study of GPCRs * Stable expression of GPCRs in mammalian cells * Heterologous expression in primary cell cultures * Expression of GPCR in Escherichia coli * Large scale expression and purification of GPCRs in mammalian cells * High-level expression of GPCRs in the Baculovirus/Sf9 cell expression system * Expression of GPCRs in Drosophila Schneider 2 cells * Methods for genetic analysis and ligand identification using heterologous GPCRs expressed in Saccharomyces cerevisiae Supplemented with numerous photographs and illustrations, Identification and Expression of G Protein-Coupled Receptors is important reading for biochemists, pharmacologists, neuroscientists, structural biologists, and anyone involved in GPCR-based research. It delivers a wealth of useful advice, practical tips, and invaluable insight into trends at the cutting-edge of current research.
Author: Katharine Herrick-Davis
Publisher: Springer
Published: 2017-08-31
Total Pages: 501
ISBN-13: 3319601741
DOWNLOAD EBOOK →G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.