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Foundations of Comparative Genomics

Author: Arcady R. Mushegian

Publisher: Elsevier

Published: 2010-07-20

Total Pages: 280

ISBN-13: 9780080546094

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

Comparative Genomics

Author: James R. Brown

Publisher: CRC Press

Published: 2007-12-03

Total Pages: 409

ISBN-13: 1420008870

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Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is highly useful in drug research, especially in the treatment of otherwise intractable conditions. Compiling first-hand descriptions of the pioneering achievements of prominent researchers, this text focuses on revolutionary advances in DNA-sequencing technology, new approaches to the organization and analysis of large phylogenetic data sets, new perspectives on evolution, and the development of novel antimicrobial drugs. This seminal volume demonstrates both the means and the fruits of cooperation across a number of fields, and in doing so lays the groundwork for continued progress.

Handbook of Comparative Genomics

Author: Cecilia Saccone

Publisher: John Wiley & Sons

Published: 2003-02-07

Total Pages: 453

ISBN-13: 047139128X

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This comprehensive reference covers the comparative methodology involved in studying molecular evolution. Providing a practical introduction to the role of bioinformatics in comparative genomics, this publication further discusses the basic technology used in genome sequencing projects and provides an overview of genome storage databases currently in use. This timely and cutting-edge text also: * Reviews the basic principles of genomics and gene expression analysis * Discusses analytic methods in proteomics and transcriptomics * Includes a comprehensive list of Web resource

Comparative Genomics

Author: Nicholas H. Bergman

Publisher: Springer Science & Business Media

Published: 2007-11-29

Total Pages: 436

ISBN-13: 1934115371

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This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel. The volume is intended for molecular biologists, biochemists and geneticists.

Comparative Genomics

Author: Joao Carlos Setubal

Publisher: Humana

Published: 2024-06-22

Total Pages: 0

ISBN-13: 9781071638378

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This second edition provides new and updated chapters covering computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those that address general techniques and concepts that apply to all organisms to others that are specialized and apply to specific biological systems such as viruses, bacteria, nematodes, and insects. Well-known comparative genomics web-based platforms are also covered in specific chapters. Written in the highly successful Methods in Molecular Biology series format, many chapters include introductions to their respective topics and step-by-step comparison procedures, demonstrated on actual sets of genome sequences. Authoritative and cutting-edge, Comparative Genomics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Genomic and Precision Medicine

Author: Geoffrey S. Ginsburg

Publisher: Academic Press

Published: 2022-04-09

Total Pages: 379

ISBN-13: 0128006536

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Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients

Computing for Comparative Microbial Genomics

Author: David Wayne Ussery

Publisher: Springer Science & Business Media

Published: 2009-02-26

Total Pages: 272

ISBN-13: 1848002548

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Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.

Comparative Genomics

Author: Melody Clark

Publisher: Springer Science & Business Media

Published: 2000-11-30

Total Pages: 266

ISBN-13: 9780412830808

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Comparative genomics: an introduction: sequencing projects and model organisms (M. S. Clark). Drosophila melanogaster: a genetic tool (U. Schafer, H. Jackle). Tunicates: models for chordate evolution and development at low genomic complexity (W. R. Jeffrey). Fugu rubripes: a fish model genome (M. S. Clark, G. Elgar). The mouse and the genomic era (T. J. Wilson, F. Lazner, I. Kola, P. J. Hertzog). Quantitative Trait Loci in domestic animals - complex inheritance patterns (E. Lipkin, m. Soller). Comparative genomics of vertebrates and the evolution of sex chromosomes (J. A. M. Graves, S. Shetty). Insights into mammalian genome organization evolution by molecular cytogenetics (J. Wienberg, L. Froniecke, R. Stanyon). Index.

Comparative Genomics

Author: Nicholas H. Bergman

Publisher:

Published: 2007

Total Pages:

ISBN-13:

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Review of the Department of Energy's Genomics: GTL Program

Author: National Research Council

Publisher: National Academies Press

Published: 2006-04-19

Total Pages: 102

ISBN-13: 0309180716

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The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.