Mechanobiology in Health and Disease

Mechanobiology in Health and Disease PDF

Author: Stefaan Verbruggen

Publisher: Academic Press

Published: 2018-08-09

Total Pages: 527

ISBN-13: 0128129530

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Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Mechanobiology of Cell-Cell and Cell-Matrix Interactions

Mechanobiology of Cell-Cell and Cell-Matrix Interactions PDF

Author: A. Wagoner Johnson

Publisher: Springer Science & Business Media

Published: 2011-02-21

Total Pages: 329

ISBN-13: 1441980830

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Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Mechanics in Development and Disease

Mechanics in Development and Disease PDF

Author:

Publisher: Elsevier

Published: 2024-07-01

Total Pages: 122

ISBN-13: 0128240334

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Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Gut developmental mechanics, Long bone developmental mechanics, Cranial plate fusion developmental mechanics, Mechanobiology and vasculogenesis, Morphogenesis and mechanics of the developing inner ear, Morphogenesis and mechanics of body wall closure in mammals, Salivary bud developmental mechanics, Lateral plate mesoderm developmental mechanics, Biomechanics of human embryo implantation, gastrulation, and organ formation, Mechanics of lung development across species, Mechanics early development in vertebrates. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Introduction to Cell Mechanics and Mechanobiology

Introduction to Cell Mechanics and Mechanobiology PDF

Author: Christopher R. Jacobs

Publisher: Garland Science

Published: 2012-11-16

Total Pages: 350

ISBN-13: 1135042659

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Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope

Forces and Tension in Development

Forces and Tension in Development PDF

Author:

Publisher: Academic Press

Published: 2011-06-02

Total Pages: 331

ISBN-13: 0123850665

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This book presents some of the most advanced experimental systems in which the role of forces has been dissected. It explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces. Presents some of the most advanced experimental systems in which the role of forces has been dissected Explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces Appeals to both physicists eager to get familiar with biological systems and to biologists curious about the physical principles behind what they observe

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology PDF

Author: Shu Chien

Publisher: Springer

Published: 2016-08-10

Total Pages: 306

ISBN-13: 1493956175

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This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Mechanobiology

Mechanobiology PDF

Author: Simon C. F. Rawlinson

Publisher: John Wiley & Sons

Published: 2017-01-31

Total Pages: 444

ISBN-13: 1118966155

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An emerging field at the interface of biology and engineering, mechanobiology explores the mechanisms by which cells sense and respond to mechanical signals—and holds great promise in one day unravelling the mysteries of cellular and extracellular matrix mechanics to cure a broad range of diseases. Mechanobiology: Exploitation for Medical Benefit presents a comprehensive overview of principles of mechanobiology, highlighting the extent to which biological tissues are exposed to the mechanical environment, demonstrating the importance of the mechanical environment in living systems, and critically reviewing the latest experimental procedures in this emerging field. Featuring contributions from several top experts in the field, chapters begin with an introduction to fundamental mechanobiological principles; and then proceed to explore the relationship of this extensive force in nature to tissues of musculoskeletal systems, heart and lung vasculature, the kidney glomerulus, and cutaneous tissues. Examples of some current experimental models are presented conveying relevant aspects of mechanobiology, highlighting emerging trends and promising avenues of research in the development of innovative therapies. Timely and important, Mechanobiology: Exploitation for Medical Benefit offers illuminating insights into an emerging field that has the potential to revolutionise our comprehension of appropriate cell biology and the future of biomedical research.

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