Fluorine in Heterocyclic Chemistry Volume 1

Fluorine in Heterocyclic Chemistry Volume 1 PDF

Author: Valentine Nenajdenko

Publisher: Springer

Published: 2014-06-30

Total Pages: 683

ISBN-13: 3319043463

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This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Fluorine in Heterocyclic Chemistry Vol. 1 and Vol. 2

Fluorine in Heterocyclic Chemistry Vol. 1 and Vol. 2 PDF

Author: Valentine Nenajdenko

Publisher: Springer

Published: 2014-05-06

Total Pages: 1200

ISBN-13: 9783319060361

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This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Fluorine in Organic Chemistry

Fluorine in Organic Chemistry PDF

Author: Richard D. Chambers

Publisher: CRC Press

Published: 2004

Total Pages: 426

ISBN-13: 9780849317903

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The introduction of carbon-fluorine bonds into organic compounds can profoundly influence their chemical and physical properties when compared to their non-fluorine-containing analogues, leading to a range of man-made materials with highly desirable properties. These molecules are of interest across the wide spectrum of industrial and academic organic chemistry, from pharmaceuticals, through fine and specialty chemicals to polymers. From Prozac to Teflon, many of the most important products of the chemical and life-science industries rely on organic fluorine chemistry for their useful properties. This book covers both the preparative methodologies and chemical properties of partially and highly fluorinated organic systems.

Fluorine in Heterocyclic Chemistry Volume 2

Fluorine in Heterocyclic Chemistry Volume 2 PDF

Author: Valentine Nenajdenko

Publisher: Springer

Published: 2014-07-08

Total Pages: 769

ISBN-13: 3319044354

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This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry PDF

Author:

Publisher: Academic Press

Published: 1994-04-22

Total Pages: 369

ISBN-13: 9780080576466

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Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and most biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

F Perfluorohalogenoorgano Compounds of Main Group Elements

F Perfluorohalogenoorgano Compounds of Main Group Elements PDF

Author: Alois Haas

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 363

ISBN-13: 3662077590

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This fourth volume of the Supplement Series supplying the Main Volumes of the series "Perfluorohalogenoorgano Compounds of Main Group Elements" (Part 1 to 9) covers the heterocyclic compounds of nitrogen as the last main group element of this series. Compounds of the elements of main group 1 to 4, 6 (without 0), and of P, As, Sb, Bi, and I are presented in the Supplement Volumes 1 to 3. Concept, organization, and selection as to coverage of the material are the same as in the preceeding volumes. Title compounds are either newly synthesized ones or those compounds already referred in the Main Volume Parts 5 and 6 for which new facts have been published. I wish to thank Prof. Dr. Dr. h. c. E. Fluck and his co-workers for their excellent cooperation and many colleagues for providing reprints and patents. One of us (U. Niemann) thanks Philips GmbH Forschungslaboratorium Aachen for generous support. November 1987 Bochum, A. Haas x Table of Contents Page 1 Three-Membered Perfluorohalogenoorgano Nitrogen Heterocycles 1-1 Formation and Preparation . . . . . . . . . . . 1-1.1 Three-Membered Heterocycles with One N Atom.

Fluorinated Heterocycles

Fluorinated Heterocycles PDF

Author: American Chemical Society. Meeting

Publisher:

Published: 2009

Total Pages: 390

ISBN-13:

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This is the first ACS symposium series book solely devoted to fluorinated heterocyclic compounds. Its contents encompasses all aspects of chemistry and applications of fluoroheterocycles including synthesis, biological activity, computational and medicinal research covering all major classes of heterocycles as well as popular fluorine-containing fragments.

The Chemistry of Fluorine

The Chemistry of Fluorine PDF

Author: T. A. O'Donnell

Publisher: Elsevier

Published: 2017-06-08

Total Pages: 113

ISBN-13: 1483146421

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Pergamon Texts in Inorganic Chemistry, Volume 5: The Chemistry of Fluorine comprises a series of reviews on the physical and chemical properties of fluorine compounds. This book discusses the general properties of fluorine and fluorides; hydrogen fluoride solvent system; ionization in halogen fluorides; fluorides of main group elements; and chemical reactivity of higher fluorides of d- and f-transition elements. The production of elemental fluorine; acidity of hydrogen fluoride; preparative reactions in halogen fluorides; specificity of fluorination in rare gas reactivity; and bonding and structure in higher transition metal are also elaborated in this text. This publication is intended for chemical engineering students and chemists researching on the characteristics of fluorine and fluorides.

Organic Fluorine Chemistry

Organic Fluorine Chemistry PDF

Author: Milos Hudlicky

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 208

ISBN-13: 1461586429

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The present book is essentially based on the lectures on the chemistry of organic compounds of fluorine that I gave in 1969 at Virginia Polytechnic Institute in Blacksburg, Virginia, as a graduate course. References to material published to the end of 1969 are included. The book is primarily meant to provide the background for such a course, and, at the same time, to be a brief survey of recent knowledge in, and an introduction to deeper study of, this area of chemistry, which has been treated in a number of com prehensive monographs. I would like to thank Professor S. C. Cohen, Syracuse University, for the compilation of the data on mass spectra and nuclear magnetic res onance spectra, and my son, Tomas Hudlicky, and my daughter, Eva Hudlickci, for their help with the indexes. MILOS HUDLICKY February 13, 1970 Virginia Polytechnic Institute and State University Blacksburg, Virginia vii Contents CHAPTER 1. Introduction ......................................................... 1 Development of Fluorine Chemistry ......................................... .

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