Fibrinolytics and Antifibrinolytics

Fibrinolytics and Antifibrinolytics PDF

Author: Fritz Markwardt

Publisher: Springer

Published: 1978-09-01

Total Pages: 682

ISBN-13: 9783540086086

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Disturbances of haemostasis and thromboembolic disorders still constitute a great problem in clinical practice. Increasing insight into the mechanism of blood coagula tion has led to more effective therapy and prophylaxis. Particularly, the understand ing of the biochemistry of fibrinolysis has provided possibilities for the pharma cological interference of these processes, which has resulted in effective haemostatic agents and useful antithrombotic ones. The development of antifibrinolytics for interfering with pathological fibrinolytic processes is nearly complete and has led to the development of drugs essential to the therapy of hyperfibrinolytic bleeding. The search for fibrinolytics for dissolving intravascular thrombi has led to highly effective compounds. This development is still under way and promising results are hoped. Spontaneous dissolution of blood clots is a phenomenon which was described a century ago. First investigations of this process assured that there is in the organism a system capable of removing the fibrin which is formed during blood coagulation after it has fulfilled its physiological function. This fibrinolytic system is specifically adapted to the degradation of insoluble fibrin into soluble degradation products. In the past 30 years, thorough investigation of this system has clarified the fibrinolytic process, its physiological role and its meaning as a pathogenetic principle. A good knowledge of these processes is required for an understanding of the effects and side effects of fibrinolytics and antifibrinolytics, which comprise the basis of methods for the detection of fibrinolytic processes in the organism and of the control of therapy with these drugs.

Fibrinolytics and Antifibrinolytics

Fibrinolytics and Antifibrinolytics PDF

Author: Fedor Bachmann

Publisher: Springer Science & Business Media

Published: 2001-01-25

Total Pages: 638

ISBN-13: 9783540661269

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This book covers basic aspects of the molecular biology, biochemistry and pharmacology of the plasminogen-plasmin (fibrinolytic) system. Individual chapters, written by well-known experts in the field, are devoted to plasminogen and its activation, the tissue-type plasminogen activator (tPA), the urinary-type-plasminogen activator (uPA), inhibitors of the fibrinolytic system, and the assembly of fibrinolytic constituents on cell surfaces. The major part of the book deals with the therapeutic use of thrombolytic agents in myocardial infarction, deep venous thrombosis, pulmonary embolism, peripheral arterial occlusions and stroke. The newest thrombolytic agents are discussed in depth. Results of major clinical trials up to the end of 1999 are critically evaluated. The volume is a modern up-to-date presentation of the entire field of the treatment of arterial and venous thromboses with thrombolytic agents.

Neurocritical Care Pharmacotherapy

Neurocritical Care Pharmacotherapy PDF

Author: Eelco F. M. Wijdicks

Publisher: Oxford University Press

Published: 2018-05

Total Pages: 353

ISBN-13: 0190684747

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Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange. This text discusses choosing the right combination of drugs; how to correctly prescribe and administer the drugs; how to monitor drug efficacy and side effects; how neurocritical care drugs interact with other medications; and comprehensive coverage of current treatment options. Key Feature of this Manual Include - A brief discussion of the basic pharmacology of each neurocritical drug, with an emphasis on how to select and use these drugs in multiple clinical contexts. - 150 drugs accompanied by a diagram for quick comprehension and drug administration guides. - Unique blending of expertise of neurointensivist with a critical care pharmacist to provide a vital resource for both specialities - References for further reading that are oriented toward utility in clinical practice.

Essentials of Blood Product Management in Anesthesia Practice

Essentials of Blood Product Management in Anesthesia Practice PDF

Author: Corey S. Scher

Publisher: Springer Nature

Published: 2021-03-12

Total Pages: 469

ISBN-13: 3030592952

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This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.

Hemostasis and Thrombosis

Hemostasis and Thrombosis PDF

Author: Hussain I. Saba

Publisher: John Wiley & Sons

Published: 2014-02-03

Total Pages: 358

ISBN-13: 1118833414

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Hemostasis and Thrombosis: Practical Guidelines in Clinical Management Edited by Hussain I Saba MD, PhD Professor of Medicine Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center USF College of Medicine Professor Emeritus Department of Malignant Hematology Moffitt Cancer Center and Research Institute Tampa, FL, USA Harold R Roberts MD Emeritus Professor of Medicine and Pathology Division of Hematology / Oncology University of North Carolina Chapel Hill, NC, USA Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients. Hemostasis and Thrombosis: Practical Guidelines in Clinical Managementcovers all aspects of the practical management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day-to-day management. The most clinically relevant material from the literature has been carefully compiled, along with: - Discussions of new and upcoming diagnostic and therapeutic modalities - Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, Hemostasis and Thrombosis: Practical Guidelines in Clinical Management will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis. Titles of related interest Practical Hemostasis and Thrombosis, 2nd Edition Key, ISBN 9781405184601 Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition Ma, ISBN 9780470659762 Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition Kitchen, ISBN 9780470671191 www.wiley.com/go/hematology

Fibrinolytics and Antifibrinolytics

Fibrinolytics and Antifibrinolytics PDF

Author: Fritz Markwardt

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 663

ISBN-13: 3642668631

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Disturbances of haemostasis and thromboembolic disorders still constitute a great problem in clinical practice. Increasing insight into the mechanism of blood coagula tion has led to more effective therapy and prophylaxis. Particularly, the understand ing of the biochemistry of fibrinolysis has provided possibilities for the pharma cological interference of these processes, which has resulted in effective haemostatic agents and useful antithrombotic ones. The development of antifibrinolytics for interfering with pathological fibrinolytic processes is nearly complete and has led to the development of drugs essential to the therapy of hyperfibrinolytic bleeding. The search for fibrinolytics for dissolving intravascular thrombi has led to highly effective compounds. This development is still under way and promising results are hoped. Spontaneous dissolution of blood clots is a phenomenon which was described a century ago. First investigations of this process assured that there is in the organism a system capable of removing the fibrin which is formed during blood coagulation after it has fulfilled its physiological function. This fibrinolytic system is specifically adapted to the degradation of insoluble fibrin into soluble degradation products. In the past 30 years, thorough investigation of this system has clarified the fibrinolytic process, its physiological role and its meaning as a pathogenetic principle. A good knowledge of these processes is required for an understanding of the effects and side effects of fibrinolytics and antifibrinolytics, which comprise the basis of methods for the detection of fibrinolytic processes in the organism and of the control of therapy with these drugs.

Trauma Induced Coagulopathy

Trauma Induced Coagulopathy PDF

Author: Hunter B. Moore

Publisher: Springer Nature

Published: 2020-10-12

Total Pages: 802

ISBN-13: 3030536068

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The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

Oxford Handbook of Anaesthesia

Oxford Handbook of Anaesthesia PDF

Author: Keith Allman

Publisher:

Published: 2006

Total Pages: 1229

ISBN-13: 0198566093

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The Oxford Handbook of Anaesthesia has been completely updated for the second edition. All chapters have been rewritten and a number of new expert authors have been brought on board. Additional new material includes anaesthesia for the critically ill, and a comprehensive section on anaesthetic risk including anaesthetic risk tables. The first section deals with preoperative issues affecting the administration of anaesthesia. Practical advice is provided covering the impact of medical disease on anaesthesia. The second section describes practical anaesthetic techniques for surgical specialties, including most subspecialties such as thoracic and neuroanaesthesia. Separate, comprehensive sections on paediatric and obstetric anaesthesia are included. The management of emergencies arising during anaesthesia are fully covered with helpful action plans and algorithms throughout. Uncommon conditions and their management are included, and there is an extensive drug formulary and guide to infusion drugs. As with the first edition, this new edition will be the essential handbook for anaesthetists, both junior and experienced, for registrars and those sitting exams, as well as ODPs and nurses involved in theatre area work and pre-assessment. It is the one book for anyone working in anaesthesia to keep to hand at all times!

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