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Fast Neutrons and High-LET Particles in Cancer Therapy

Author: Rita Engenhart-Cabillic

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 225

ISBN-13: 3642787746

Fast neutron therapy was introduced in London in 1970. The book gives an overview of the developments of the past 28 years, assesses the results of fast neutron treatment, and reviews the compiled clinical data worldwide. The authors describe the radiobiological profile of the neutron beams and evaluate the neutron RBE for secondary cancer induction, they introduce heavy-ion therapy, which combines high physical selectivity with the biological advantages of high-LET radiation for some tumor types, and finally they describe the very recent developments in Boron Neutron Capture Therapy (BNCT).

Fast Neutron Rad And High-let Particles in Cancer Therapy

Author: R. Engenhart

Publisher:

Published: 1998-07-17

Total Pages:

ISBN-13: 9780387576329

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High-LET Radiations in Clinical Radiotherapy

Author: G. W. Barendsen

Publisher: Elsevier

Published: 2013-09-11

Total Pages: 298

ISBN-13: 1483189082

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High-LET Radiations in Clinical Radiotherapy covers the proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and other High-LET Particles in Clinical Radiotherapy. The title presents papers that report the experiences in utilizing High-LET radiations in clinical radiotherapy. The coverage of the text includes observations on the reactions of normal and malignant tissues to a standard dose; and clinical observations of early and late normal tissue injury and tumor control in patients receiving fast neutron irradiation. The selection also covers results of fast neutron radiotherapy at Amsterdam; and results of clinical applications with fast neutrons in Edinburgh. The book will be of great use to students and practitioners of medical technology.

Heavy Particle Radiotherapy

Author: M Raju

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 513

ISBN-13: 0323147585

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Heavy Particle Radiotherapy covers the significant advances in the application of radiotherapy to cancer treatment. This book is composed of eight chapters that focus on the performance of several heavy particles. The introductory chapters describe the radiobiological phenomena of interest in radiotherapy and their modifications with increasing linear energy transfer. The remaining chapters discuss the physical aspects, cellular effects, and radiotherapy potential of heavy particles, including neutrons, protons, helium and heavy ions, and negative pions.

Neutron Capture Therapy

Author: Wolfgang A.G. Sauerwein

Publisher: Springer Science & Business Media

Published: 2012-11-05

Total Pages: 545

ISBN-13: 3642313345

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Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

The Physics and Radiobiology of Fast Neutron Beams

Author: David K. Bewley

Publisher: CRC Press

Published: 1989-10-01

Total Pages: 206

ISBN-13: 9780852740934

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Over fifty years have passed since the first patient was treated with fast neutrons, but this form of therapy is still a matter of bitter dispute. Neutron generators have been installed in many countries and now patients can be treated with equipment that is technically similar to modern megavoltage x-ray equipment. The Physics and Radiobiology of Fast Neutron Beams presents a full discussion of the physical and radiobiological factors governing the production and use of fast neutron beams for therapy. The book discusses vastly improved neutron generators, advances in the standardization of dosimetric methods, and the specification of radiation quality. In addition, it explores nuclear methods of analysis, particularly neutron activation analysis in vivo. Influencing the place of radiotherapy with neutrons and other heavy particles, the radiobiological factors governing the treatment of cancer with radiation are examined. The author also studies the radiation hazard of neutrons, a matter of importance in the use of neutrons for chemical analysis in vivo. The Physics and Radiobiology of Fast Neutron Beams will be a valuable introduction to the subject for radiotherapists, medical physicists, radiographers, and radiobiologists new to the field. The book is also a useful summary of current knowledge for those already established in the use of fast neutrons for medical purposes.

Advances in Neutron Capture Therapy

Author: R.F. Barth

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 776

ISBN-13: 1461529786

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Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

Fast Neutrons and High-LET Particles in Cancer Therapy

Author: Rita Engenhart-Cabillic

Publisher: Springer

Published: 1998-05-28

Total Pages: 242

ISBN-13:

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Frontiers in Neutron Capture Therapy

Author: M. Frederick Hawthorne

Publisher: Springer

Published: 2013-11-11

Total Pages: 1389

ISBN-13: 1461512859

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Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

Advances in Nuclear Data and All-particle Transport for Radiation Oncology

Author:

Publisher:

Published: 1994

Total Pages: 6

ISBN-13:

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Fast neutrons have been used to treat over 15,000 cancer patients worldwide and proton therapy is rapidly emerging as a treatment of choice for tumors around critical anatomical structures. Neutron therapy requires evaluated data to (approximately)70 MeV while proton therapy requires data to (approximately)250 MeV. Collaboration between Lawrence Livermore National Laboratory (LLNL) and the medical physics community has revealed limitations in nuclear cross section evaluations and radiation transport capabilities that have prevented neutron and proton radiation therapy centers from using Monte Carlo calculations to accurately predict dose in patients. These evaluations require energy- and angle-dependent cross sections for secondary neutrons, charged-particles and recoil nuclei. We are expanding the LLNL nuclear databases to higher energies for biologically important elements and have developed a three-dimensional, all-particle Monte Carlo radiation transport code that uses computer-assisted-tomography (CT) images as the input mesh. This code, called PEREGRINE calculates dose distributions in the human body and can be used as a tool to determine the dependence of dose on details of the evaluated nuclear data. In this paper, we will review the status of the nuclear data required for neutron and proton therapy, describe the capabilities of the PEREGRINE package, and show the effects of tissue inhomogeneities on dose distribution.