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Experimental Models of Infection, Inflammation and Injury

Author:

Publisher: Academic Press

Published: 2022-03-31

Total Pages: 360

ISBN-13: 0323899463

Experimental Models of Infection, Inflammation and Injury, Volume 168 provides step-by-step protocols for scientific researchers to effectively utilize experimental model systems. Chapters in this new release include Induction and Evaluation of Murine T Cell Transfer Colitis, Modelling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity, Mouse models of Graft-Versus-Host Disease, Preclinical Model of Multiple Sclerosis: Methods in Autoimmune Demyelination, Preclinical model of Multiple Sclerosis: focal, chemical or demyelination, Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips, and more. Other notable sections cover Rheumatoid Arthritis: Methods for Two Murine Models, Induction of Pancreatitis in Mice with Susceptibility to Pancreatic Cancer, Small Animal Models of Thermal Injury, Large Animal Models of Thermal Injury, Small animal models of localized heart irradiation, Methods for Induction and Assessment of Intestinal Permeability in Rodent Models of Radiation Injury, and more. Provides precise, step-by-step guidance on how to implement experimental systems Presents a comprehensive background on the disease the model is being used to study Offers insights into how the described disease models compare to other existing systems

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2019-01-26

Total Pages: 628

ISBN-13: 0128138211

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Bioactive Food as Dietary Interventions for Arthritis and Inflammatory Diseases, Second Edition is a valuable scientific resource that focuses on the latest advances in bioactive food research and the potential benefit of bioactive food choice on arthritis. Written by experts from around the world, the book presents important information that can help improve the health of those at risk for arthritis and related conditions using food selection as its foundation. Serves as a starting point for in-depth discussions in academic settings Offers detailed, well-documented reviews outlining the ability of bioactive foods to improve and treat arthritis Includes updated research on the global epidemic of diabetes Updated with current research on antioxidant flavonoids, anti-Inflammatory natural foods, ginger and the effects of beef on inflammation Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases that share common etiological pathways

Polymicrobial Diseases

Author: Kim A. Brogden

Publisher:

Published: 2002

Total Pages: 460

ISBN-13:

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Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.

Molecular Basis of Health and Disease

Author: Undurti N. Das

Publisher: Springer Science & Business Media

Published: 2011-04-02

Total Pages: 591

ISBN-13: 940070495X

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The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

Preventing Developmental Brain Injury – From Animal Models to Clinical Trials

Author: Masahiro Tsuji

Publisher: Frontiers Media SA

Published: 2019-10-23

Total Pages: 316

ISBN-13: 2889630757

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Fundamentals of Inflammation

Author: Charles N. Serhan

Publisher: Cambridge University Press

Published: 2010-04-26

Total Pages: 489

ISBN-13: 1139936670

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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Pathophysiology of the Enteric Nervous System

Author: Robin Spiller

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 272

ISBN-13: 0470760036

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Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.

Recent Advances in Pediatrics - 21 - Hot Topics

Author: Suraj Gupte

Publisher: JP Medical Ltd

Published: 2013-06-30

Total Pages: 536

ISBN-13: 9350257742

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Volume 21 of Recent Advances in Pediatrics is a compilation of reviews bringing trainees and physicians fully up to date with key developments in the field. Topics in this new volume include advances in neonatology, nutrition, gastroenterology and hepatology, psychiatry, endocrinology and critical care. Separate chapters are dedicated to vaccines and pharmacotherapy. Presented in an easy to follow format, Volume 21 follows a multidisciplinary approach. Each chapter finishes with a summary of key learning points and extensive references for further reading. Clinical photographs, illustrations and tables enhance learning. Key points New, updated volume presenting latest developments in paediatrics Multidisciplinary approach, easy to follow format Extensive references and key learning points summarised in each chapter Hot Topics Volume 20 published in 2011

Handbook of Animal Models of Infection

Author: Merle A. Sande

Publisher: Academic Press

Published: 1999-05-28

Total Pages: 1136

ISBN-13: 9780080533551

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Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. Discusses ethical and safety aspects in an introductory background section Covers principles of animal care and current techniques appropriate for the use of animal models of infection Details a wide range of animals including rodents, rabbits, cats, and primates Provides hands-on descriptions of how to set up the model Discusses the major advantages and limitations of each model Ensures full coverage of bacterial, fungal, viral, and parasitic infections

Neurology of the Newborn E-Book

Author: Joseph J. Volpe

Publisher: Elsevier Health Sciences

Published: 2008-06-11

Total Pages: 1109

ISBN-13: 143772079X

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The 5th edition of this indispensable resource captures the latest insights in neonatal neurology in a totally engaging, readable manner. World authority Dr. Joseph Volpe has completely revised his masterwork from cover to cover, describing everything from the most up-to-the-minute discoveries in genetics through the latest advances in the diagnosis and management of neurologic disorders. He delivers all the clinical guidance you need to provide today's most effective care for neonates with neurological conditions. Provides comprehensive coverage of neonatal neurology, solely written by the field’s founding expert, Dr. Joseph Volpe - for a masterful, cohesive source of answers to any question that arises in your practice. Focuses on clinical evaluation and management, while also examining the many scientific and technological advances that are revolutionizing neonatal neurology. Organizes disease-focused chapters by affected body region for ease of reference. Offers comprehensive updates from cover to cover to reflect all of the latest scientific and clinical knowledge, from our most current understanding of the genetic underpinnings of neurologic disease, through the most recent neuroimaging advances . . . state-of-the-art guidelines for evaluation, diagnosis, and prognosis . . . and the newest management approaches for every type of neonatal neuropathology. Features a wealth of new, high-quality images that capture the many advances in neonatal neuroimaging, including numerous MR images.