Experimental Design and Reproducibility in Preclinical Animal Studies

Experimental Design and Reproducibility in Preclinical Animal Studies PDF

Author: José M. Sánchez Morgado

Publisher: Springer Nature

Published: 2021-08-31

Total Pages: 277

ISBN-13: 3030661474

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This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Good Research Practice in Non-Clinical Pharmacology and Biomedicine PDF

Author: Anton Bespalov

Publisher: Springer Nature

Published: 2020-01-01

Total Pages: 424

ISBN-13: 3030336565

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This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Animal Experimentation: Working Towards a Paradigm Change

Animal Experimentation: Working Towards a Paradigm Change PDF

Author: Kathrin Herrmann

Publisher: BRILL

Published: 2019-04-30

Total Pages: 749

ISBN-13: 9004391193

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Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Guidance for the Description of Animal Research in Scientific Publications

Guidance for the Description of Animal Research in Scientific Publications PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2011-09-16

Total Pages: 42

ISBN-13: 030921954X

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The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

Essentials of Laboratory Animal Science: Principles and Practices

Essentials of Laboratory Animal Science: Principles and Practices PDF

Author: P. Nagarajan

Publisher: Springer Nature

Published: 2021-07-23

Total Pages: 797

ISBN-13: 981160987X

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This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

The Design of Animal Experiments

The Design of Animal Experiments PDF

Author: Michael Festing

Publisher: SAGE Publications Limited

Published: 2016-12-14

Total Pages: 0

ISBN-13: 9781473974630

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Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.

The Design of Animal Experiments

The Design of Animal Experiments PDF

Author: Michael F. W. Festing

Publisher: Royal Society of Medicine PressLtd

Published: 2002

Total Pages: 112

ISBN-13: 9781853155130

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"Where there is no alternative to the use of experimental animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those that use too many or use them incorrectly may be subjecting them to unnecessary pain, distress or lasting harm. This book is aimed at all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when designing more complex experiments. It covers many aspects of experimental design, such as choice of experimental animal, which are not considered by most statistics textbooks. Conversely, it does not cover the more advanced designs or statistical methods, so it should, ideally, be used in conjunction with more conventional statistics textbooks."--Page 4 of cover.

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