Exosomes in Cardiovascular Diseases

Exosomes in Cardiovascular Diseases PDF

Author: Junjie Xiao

Publisher: Springer

Published: 2017-09-19

Total Pages: 307

ISBN-13: 9811043973

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The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Mesenchymal Stem Cell Derived Exosomes

Mesenchymal Stem Cell Derived Exosomes PDF

Author: Yaoliang Tang

Publisher: Academic Press

Published: 2015-09-02

Total Pages: 288

ISBN-13: 0128004975

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Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Exosomes

Exosomes PDF

Author: Larry Edelstein

Publisher: Academic Press

Published: 2019-10-16

Total Pages: 548

ISBN-13: 0128160543

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Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing

Osteogenesis and Bone Regeneration

Osteogenesis and Bone Regeneration PDF

Author: Haisheng Yang

Publisher: BoD – Books on Demand

Published: 2019-04-24

Total Pages: 143

ISBN-13: 1789857678

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Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

Extracellular Vesicles and Their Importance in Human Health

Extracellular Vesicles and Their Importance in Human Health PDF

Author: Ana Gil De Bona

Publisher: BoD – Books on Demand

Published: 2020-03-04

Total Pages: 172

ISBN-13: 1789239435

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Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases.

Comorbidity in Rheumatic Diseases

Comorbidity in Rheumatic Diseases PDF

Author: Yasser El Miedany

Publisher: Springer

Published: 2017-08-24

Total Pages: 433

ISBN-13: 3319599631

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This book explores comorbidity in patients with rheumatic diseases and details both care and treatment options in standard clinical practice. Patients with rheumatic diseases are clinically complex, and the interplay of their disease activity with associated conditions may lead to increased morbidity and mortality. Recently there have been major advances in the management of rheumatic diseases, however, without addressing the potential comorbid conditions, including cardiovascular disease; pulmonary disease; and depression; outcomes remain poor. ​​​ With its 19 chapters, covering the management of major rheumatic diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus , and osteoarthritis), potential comorbidities and treatment recommendations, as well as possible interactions between conditions; this book addresses the gap between textbook medicine and day to day patients' care. Authors also discuss the new hot issue of the comorbidity index, comparing the standard tools to the recently developed indices and how they can assist the rheumatologists in determining disease burden, prognosis, and comorbidity probability. This book is an ideal clinical guide and reference that enables rheumatologists, internal medicine physicians, and residents to address the full clinical expression of these rheumatic diseases with views towards prevention or early management of comorbid conditions.

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