Integrating Clinical Research into Epidemic Response

Integrating Clinical Research into Epidemic Response PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2017-07-26

Total Pages: 343

ISBN-13: 0309457769

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The 2014â€"2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014â€"2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak. Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014â€"2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.

The Ebola Epidemic in West Africa

The Ebola Epidemic in West Africa PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-12-30

Total Pages: 137

ISBN-13: 0309450063

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The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

The International Politics of Ebola

The International Politics of Ebola PDF

Author: Anne Roemer-Mahler

Publisher: Routledge

Published: 2018-10-11

Total Pages: 188

ISBN-13: 1351866818

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The outbreak of Ebola virus disease that gripped Liberia, Guinea and Sierra Leone through much of 2014 and 2015 was undoubtedly a health emergency, yet it was also a global political event. This book examines the international politics of the Ebola outbreak in all of its dimensions, critically assessing the global response, examining what the outbreak can tell us about contemporary global health governance, and examining the inequalities and injustices that were laid bare. In doing so, the book shows how some of the concepts, debates and findings from the growing field of global health research in International Relations can help both in furthering understanding of the Ebola crisis and also in improving policy responses to future infectious disease outbreaks. This book was originally published as a special edition of Third World Quarterly.

Update on the U. S. Public Health Response to the Ebola Outbreak

Update on the U. S. Public Health Response to the Ebola Outbreak PDF

Author: United States. Congress

Publisher: Createspace Independent Publishing Platform

Published: 2017-12-02

Total Pages: 212

ISBN-13: 9781981319299

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Update on the U.S. public health response to the Ebola outbreak : hearing before the Subcommittee on Oversight and Investigations of the Committee on Energy and Commerce, House of Representatives, One Hundred Thirteenth Congress, second session, November 18, 2014.

Global Management of Infectious Disease After Ebola

Global Management of Infectious Disease After Ebola PDF

Author: Sam F. Halabi

Publisher: Oxford University Press

Published: 2016-09-28

Total Pages: 256

ISBN-13: 0190604905

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The 2014-2015 Ebola outbreak in West Africa shocked the world with its devastation and its rapid migration to multiple continents. As the systems meant to respond to this sort of epidemic failed, the disease exposed not just weaknesses in international infectious disease surveillance and management, but the failures of governments, humanitarian organizations, and international institutions to handle the legal, ethical, and economic questions that arose with an event of this scale. GLOBAL MANAGEMENT OF INFECTIOUS DISEASE AFTER EBOLA unites the insights of Ebola's first responders with those the world's foremost experts in law, economics, vaccine development, and global migration to identify missed opportunities from the Ebola crisis -- and to apply these lessons to emerging infectious disease threats. Framed with critical discussions of both the global health financing infrastructures that precipitated the response and the ethical and human rights dilemmas that resulted from it, this volume is much more than postmortem to an outbreak: it is a vital, sometimes damning examination of where we've been and where we're going in the face of emerging infectious diseases.

Managing the global health response to epidemics

Managing the global health response to epidemics PDF

Author: Mathilde Bourrier

Publisher: Routledge

Published: 2019-02-12

Total Pages: 294

ISBN-13: 1351263021

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Recent epidemics have prompted large-scale international interventions, aimed at mitigating the spread of disease in a globalized world. During a crisis, however, global health actions – including planning and organizing, communicating about risk, and cost–benefit evaluations – aren’t usually part of a single, integrated global response. Arguing that an uncoordinated approach can be challenged by local conditions and expectations, generating a wide range of resistance and difficulties, this volume provides important insights for future outbreak management and global health governance. Drawing on experiences with A(H1N1) and Ebola virus disease, the book is divided into three parts looking at how responses to global health crises have developed, lessons learned from particular pandemics and the ethical implications of our management of them. Individual chapters focus on, among other issues, financing, cost–benefit analysis, matrix management, risk communication and organizational strategies. Taking a social science perspective, this valuable book outlines the current state of global health emergency responses and explores ways in which they can be improved. It is a useful read for academics and practitioners interested in global health, the sociology of health and illness, health economics and emergency management.

More Than a Health Crisis

More Than a Health Crisis PDF

Author: Jessica Kirk

Publisher: MIT Press

Published: 2023-10-24

Total Pages: 241

ISBN-13: 0262545691

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How the West African Ebola epidemic was transformed from an urgent and distant tragedy into an existential threat to American lives—establishing the dynamics that would later dominate the US response to epidemics such as COVID-19. In 2014 and 2015, the viral Ebola epidemic in West Africa inspired breathless US media coverage and became the subject of heated public debate over just how to understand the security issue that the outbreak presented. Was it a security concern because of the lives at risk in West Africa? Or because of its threat to regional and global stability? Or was it potentially a threat to the American people? In More Than a Health Crisis, Jessica Kirk reveals how these varied positions spoke to divisions within the American public, concerning how we think about and respond to uncertainty, competing expertise, and securitization. Kirk insightfully examines how experts in different fields offered conflicting assessments of the risks posed by Ebola, and then goes on to analyze how the US press undermined the authority of the public health experts who accurately predicted that the virus posed little danger to Americans. Reading the media coverage of the Ebola epidemic as a case study in the biopolitics of fear, Kirk considers how the US response reflected not only anxieties over globalization but also long-held narratives about the “Dark Continent.” Finally, Kirk shows how the US and global public response to the Ebola outbreak challenged traditional models of securitization and identifies patterns that have tragically recurred with subsequent epidemics such as COVID-19 and monkeypox.

Exploring Lessons Learned from a Century of Outbreaks

Exploring Lessons Learned from a Century of Outbreaks PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2019-06-05

Total Pages: 231

ISBN-13: 0309490359

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In November 2018, an ad hoc planning committee at the National Academies of Sciences, Engineering, and Medicine planned two sister workshops held in Washington, DC, to examine the lessons from influenza pandemics and other major outbreaks, understand the extent to which the lessons have been learned, and discuss how they could be applied further to ensure that countries are sufficiently ready for future pandemics. This publication summarizes the presentations and discussions from both workshops.

The Ebola Epidemic in West Africa

The Ebola Epidemic in West Africa PDF

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-11-30

Total Pages: 137

ISBN-13: 0309450098

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The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.