Evolution of the Genetic Code

Evolution of the Genetic Code PDF

Author: Shōzō Ōsawa

Publisher:

Published: 1995

Total Pages: 240

ISBN-13:

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The genetic code was deciphered experimentally around 1966 and for a number of years scientists considered it to be "universal" for all forms of life. In 1981 researchers shocked the scientific community with the discovery that the code differed in mitochondria and certain other organisms, evidence that the genetic code was still evolving. This book discusses the distribution and origin of the non-universal codes and examines the possible mechanisms of code changes, making it essential reading for all those interested in evolutionary genetics.

The Genetic Code and the Origin of Life

The Genetic Code and the Origin of Life PDF

Author: Lluis Ribas de Pouplana

Publisher: Springer Science & Business Media

Published: 2007-04-03

Total Pages: 266

ISBN-13: 0387268871

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Early Thoughts on RNA and the Origin of Life The full impact of the essential role of the nucleic acids in biological systems was forcefully demonstrated by the research community in the 1950s. Although Avery and his collaborators had identified DNA as the genetic material responsible for the transformation of bacteria in 1944, it was not until the early 1950s that the Hershey-Chase experiments provided a more direct demonstration of this role. Finally, the structural DNA double helix proposed by Watson and Crick in 1953 clearly created a structural frame work for the role of DNA as both information carrier and as a molecule that could undergo the necessary replication needed for daughter cells. Research continued by Kornberg and his colleagues in the mid-1950s emphasized the biochemistry and enzymology of DNA replication. At the same time, there was a growing interest in the role of RNA. The 1956 dis covery by David Davies and myself showed that polyadenylic acid and polyuridylic acid could form a double-helical RNA molecule but that it differed somewhat from DN A A large number of experiments were subsequendy carried out with synthetic polyribonucleotides which illustrated that RNA could form even more complicated helical structures in which the specificity of hydrogen bonding was the key element in determining the molecular conformation. Finally, in I960,1 could show that it was possible to make a hybrid helix.

Who Wrote the Book of Life?

Who Wrote the Book of Life? PDF

Author: Lily E. Kay

Publisher: Stanford University Press

Published: 2000

Total Pages: 476

ISBN-13: 9780804734172

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This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technology—and consequently as a “book of life.” This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the “book of life” metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s). Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic “book of life.”

The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick

The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick PDF

Author: Koji Tamura (Ed.)

Publisher:

Published: 2018

Total Pages: 192

ISBN-13:

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The genetic code is one of the greatest discoveries of the 20th century as it is central to life itself. It is the algorithm that connects 64 RNA triplets to 20 amino acids, thus functioning as the Rosetta Stone of molecular biology. Following the discovery of the structure of DNA by James Watson and Francis Crick in 1953, George Gamow organized the 20-member "RNA Tie Club" to discuss the transmission of information by DNA. Crick, Sydney Brenner, Leslie Barnett, and Richard Watts-Tobin first demonstrated the three bases of DNA code for one amino acid. The decoding of the genetic code was begun by Marshall Nirenberg and Heinrich Matthaei and was completed by Har Gobind Khorana. Then, finally, Brenner, Barnett, Eugene Katz, and Crick placed the last piece of the jigsaw puzzle of life by proving that UGA was a third stop codon. In the mid-1960s, Carl Woese proposed the "stereochemical hypothesis", which speculated that the genetic code derives from a type of codon-amino acid-pairing interaction. The origin and evolution of the genetic code remains a mystery despite numerous theories and attempts to understand these. In this Special Issue, experts in the field present their thoughts and views on this topic. Because 2016 commemorated the 100th anniversary of the birth of Francis Crick, the Guest Editor of this Special Issue also dedicates all articles included herein to the memory of Francis Crick.

Advances in Artificial Systems for Medicine and Education

Advances in Artificial Systems for Medicine and Education PDF

Author: Zhengbing Hu

Publisher: Springer

Published: 2017-08-19

Total Pages: 344

ISBN-13: 3319673491

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This book presents an overview of the latest artificial intelligence systems and methods, which have a broad spectrum of effective and sometimes unexpected applications in medical, educational and other fields of sciences and technology. In digital artificial intelligence systems, scientists endeavor to reproduce the innate intellectual abilities of human and other organisms, and the in-depth study of genetic systems and inherited biological processes can provide new approaches to create more and more effective artificial intelligence methods. The book focuses on the intensive development of bio-mathematical studies on living organism patents, which ensure the noise immunity of genetic information, its quasi-holographic features, and its connection with the Boolean algebra of logic used in technical artificial intelligence systems. In other words, the study of genetic systems and creation of methods of artificial intelligence go hand in hand, mutually enriching enrich each other. These proceedings comprise refereed papers presented at the 1st International Conference of Artificial Intelligence, Medical Engineering, and Education (AIMEE2017), held at the Mechanical Engineering Institute of the Russian Academy of Sciences, Moscow, Russia on 21–23 August 2017. The topics discussed include advances in thematic mathematics and bio-mathematics; advances in thematica medical approaches; and advances in thematic technological and educational approaches. The book is a compilation of state-of-the-art papers in the field, covering a comprehensive range of subjects that are relevant to business managers and engineering professionals alike. The breadth and depth of these proceedings make them an excellent resource for asset management practitioners, researchers and academics, as well as undergraduate and postgraduate students interested in artificial intelligence and bioinformatics systems as well as their growing applications

Engineering the Genetic Code

Engineering the Genetic Code PDF

Author: Nediljko Budisa

Publisher: John Wiley & Sons

Published: 2006-05-12

Total Pages: 312

ISBN-13: 3527607099

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The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application. Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique. Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given. Essential reading for all molecular life scientists who want to stay ahead in their research.

The Codes of Life

The Codes of Life PDF

Author: Marcello Barbieri

Publisher: Springer Science & Business Media

Published: 2007-10-26

Total Pages: 443

ISBN-13: 1402063407

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Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution.