Evaluation of certain veterinary drug residues in food
Author: World Health Organization
Publisher: World Health Organization
Published: 2022-09-05
Total Pages: 107
ISBN-13: 9240057587
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Evaluation of certain veterinary drug residues in food: ninety-fourth report of the Joint FAO/WHO Expert Committee on Food Additives
Author: World Health Organization
Publisher: Food & Agriculture Org.
Published: 2022-10-05
Total Pages: 107
ISBN-13: 9251369003
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). It covers topics such as the parallel review process; estimation of dietary exposure to veterinary drug residues; a risk-based decision tree approach for safety evaluation; assessment of the potential effects of residues on the human intestinal microbiome. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: two antiparasitic agents (imidacloprid, ivermectin) and one coccidiostat (nicarbazin). Additionally, further evaluation of the parasiticide selamectin is included as part of a pilot in support of the proposed parallel review process. Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.
Toxicological evaluation of certain veterinary drug residues in food
Author: World Health Organization
Publisher: World Health Organization
Published: 2023-04-28
Total Pages: 134
ISBN-13: 9240068414
DOWNLOAD EBOOK →Evaluation of certain veterinary drug residues in food
Author: World Health Organization
Publisher: Food & Agriculture Org.
Published: 2020-02-13
Total Pages: 130
ISBN-13: 9251321205
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including harmonization of residue definition, use of scientific literature in risk assessment, toxicological profiling of compounds and less-than-lifetime dietary exposure assessment, combined exposure to multiple chemicals, and microbiological effects on the safety evaluation of veterinary drug residues in food. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: three insecticides (diflubenzuron, ethion and flumethrin), three antimicrobials (fosfomycin, halquinol and ivermectin) and one antiparasitic agent (selamectin). Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes (ADIs) and proposed MRLs.
Evaluation of Certain Veterinary Drug Residues in Food
Author: Joint FAO/WHO Expert Committee on Food Additives. Meeting
Publisher: World Health Organization
Published: 2009
Total Pages: 144
ISBN-13: 9241209542
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including a hypothesis-driven decision tree approach for the safety evaluation of residues of veterinary drugs; comments on the Committee for Veterinary Products for Medicinal Use reflection paper on the new approach developed by JECFA for exposure and maximum residue limit (MRL) assessment of residues; residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; comments on a paper entitled "Risk-assessment policies: Differences among jurisdictions"; and the use of no-observed-effect level (NOEL) and no-observed-adverse-effect level (NOAEL) in JECFA assessments. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (avilamycin, tilmicosin, tylosin), one authentic (triclabendazole), one production aid (melengestrol acetate), two antimicrobial agents and production aids (monesin and narasin), a glucocorticosteroid (dexamethasone) and an antimicrobial agent ands contaminant (malachite green). Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes (ADI's) and proposed MRL's.
Evaluation of Certain Veterinary Drug Residues in Food
Author: Joint FAO/WHO Expert Committee on Food Additives. Meeting
Publisher: World Health Organization
Published: 2006
Total Pages: 89
ISBN-13: 9241209399
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of JECFA, including compounds without an ADI or MRL; recommendations on principles and methods in derivation of MRLs, including a new procedure for estimating chronic dietary intakes; the use of a spreadsheet-based procedure for the statistical evaluation of residue depletion data; a revised approach for the derivation of microbiological ADIs; and the Committee's review of and comments on documents provided by the Codex Committee on Residues of Veterinary Drugs. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: three antimicrobial agents (colistin, erythromycin, flumequine), two production aids (melengestrol acetate, ractopamine hydrochloride, an insecticide (trichlorfon (metrifonate)), and an anthelminthic (triclabendazole). In addition, the attempt by the Committee to use tylosin as an example to investigate if evaluations are possible based on published data in the absence of data submissions from sponsors is described. Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.
Evaluation of Certain Veterinary Drug Residues in Food
Author: Joint FAO/WHO Expert Committee on Food Additives
Publisher: World Health Organization
Published: 2001-05
Total Pages: 104
ISBN-13: 9241209003
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of veterinary drugs within the terms of reference of JECFA, including compounds without an ADI or MRL; recommendations on principles and methods in derivation of MRLs, including a new procedure for estimating chronic dietary intakes; the use of a spreadsheet-based procedure for the statistical evaluati.
Residue evaluation of certain veterinary drugs
Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Org.
Published: 2023-06-15
Total Pages: 192
ISBN-13: 9251377820
DOWNLOAD EBOOK →This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 94th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held virtually from 16 to 27 May 2022. The JECFA meeting was specifically convened to consider residues of veterinary drugs in food. The tasks before the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food, establishing acceptable daily intakes (ADIs) and acute reference doses (ARfDs), and recommending maximum residue limits (MRLs) for such residues when the drugs under consideration are administered to food-producing animals in accordance with good veterinary practice (GVP) in the use of veterinary drugs. The present volume contains monographs on the evaluations of residue data of substances scheduled for evaluation at the request of the Codex Committee on Residues of Veterinary Drugs in Food. A summary of the recommendations on compounds on the agenda and further information required are also presented in this report.
Evaluation of Certain Veterinary Drug Residues in Food
Author: Joint FAO/WHO Expert Committee on Food Additives
Publisher:
Published: 1989
Total Pages: 62
ISBN-13: 9789241207805
DOWNLOAD EBOOK →Evaluation of Certain Veterinary Drug Residues in Food
Author: World Health Organization
Publisher: World Health Organization
Published: 2016-02-22
Total Pages: 128
ISBN-13: 9241209976
DOWNLOAD EBOOK →This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) including MRLs for generic fish species acute reference doses (ARfDs) for veterinary drugs an approach for dietary exposure assessment of compounds used for multiple purposes (i.e. veterinary drugs and pesticides) dietary exposure assessment for less-than-lifetime exposure and the assessment of short-term (90-day and 12-month) studies in dogs. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: two insecticides (diflubenzuron and teflubenzuron) an antiparasitic agent (ivermectin) an ectoparasiticide (sisapronil) and a B2-adrenoceptor agonist (zilpaterol hydrochloride). In addition the Committee considered issues raised in concern forms from the Codex Committee on Residues of Veterinary Drugs in Foods on lasalocid sodium an antiparasitic agent. Annexed to the report is a summary of the Committee's recommendations on these drugs including acceptable daily intakes (ADIs) ARfDs and proposed MRLs.
