Principles of Research Design and Drug Literature Evaluation

Principles of Research Design and Drug Literature Evaluation PDF

Author: Rajender R. Aparasu

Publisher: Jones & Bartlett Publishers

Published: 2014-03-07

Total Pages: 400

ISBN-13: 1449691315

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Principles of Research Design and Drug Literature Evaluation is a unique resource that provides a balanced approach covering critical elements of clinical research, biostatistical principles, and scientific literature evaluation techniques for evidence-based medicine. This accessible text provides comprehensive course content that meets and exceeds the curriculum standards set by the Accreditation Council for Pharmacy Education (ACPE). Written by expert authors specializing in pharmacy practice and research, this valuable text will provide pharmacy students and practitioners with a thorough understanding of the principles and practices of drug literature evaluation with a strong grounding in research and biostatistical principles. Principles of Research Design and Drug Literature Evaluation is an ideal foundation for professional pharmacy students and a key resource for pharmacy residents, research fellows, practitioners, and clinical researchers. FEATURES * Chapter Pedagogy: Learning Objectives, Review Questions, References, and Online Resources * Instructor Resources: PowerPoint Presentations, Test Bank, and an Answer Key * Student Resources: a Navigate Companion Website, including Crossword Puzzles, Interactive Flash Cards, Interactive Glossary, Matching Questions, and Web Links From the Foreword: "This book was designed to provide and encourage practitioner’s development and use of critical drug information evaluation skills through a deeper understanding of the foundational principles of study design and statistical methods. Because guidance on how a study’s limited findings should not be used is rare, practitioners must understand and evaluate for themselves the veracity and implications of the inherently limited primary literature findings they use as sources of drug information to make evidence-based decisions together with their patients. The editors organized the book into three supporting sections to meet their pedagogical goals and address practitioners’ needs in translating research into practice. Thanks to the editors, authors, and content of this book, you can now be more prepared than ever before for translating research into practice." L. Douglas Ried, PhD, FAPhA Editor-in-Chief Emeritus, Journal of the American Pharmacists Association Professor and Associate Dean for Academic Affairs, College of Pharmacy, University of Texas at Tyler, Tyler, Texas

Drug Information

Drug Information PDF

Author: Patrick M. Malone

Publisher: McGraw Hill Professional

Published: 2010-05-12

Total Pages: 907

ISBN-13: 0071492038

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Extensive coverage of the Internet as a source of and distribution means for drug information, and detailed sections on evaluating medical literature from clinical trials Audience includes Pharmacists, Pharmacy students and Pharmacy schools Updated to include using PDAs for medication information Covers the ethical and legal aspects of drug information management Nothing else like it on the market

Evaluating Drug Literature

Evaluating Drug Literature PDF

Author: Richard L. Slaughter

Publisher: McGraw-Hill/Appleton & Lange

Published: 2001

Total Pages: 390

ISBN-13:

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Important new textbook gives students of pharmacy a one-stop resource to develop the necessary skills to find, read, understand, and evaluate drug literature. Epidemiological and mathematical concepts are explained clearly and concisely with real examples, not hypothetical case studies. Key concepts correlation and regression analysis, survival curve analysis, medical informatics, research process and experimental design are presented clearly and made relevant to the pharmacy arena

Principles of Scientific Literature Evaluation

Principles of Scientific Literature Evaluation PDF

Author: Frank J. Ascione

Publisher: American Pharmacists Association (APhA)

Published: 2001

Total Pages: 212

ISBN-13:

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This volume hinges on a structured, question-based approach to evaluating clinical drug trials, the major type of scientific study that practising pharmacists review. Growing out of the author's 20 years of teaching the subject to PharmD students, the instructional method is well established and effective. The book refines and expands upon the scientific literature evaluation section of Principles of Drug Information and Scientific Literature Evaluation (1994) a textbook co-authored by Frank J. Ascoine.

Drug Safety Evaluation

Drug Safety Evaluation PDF

Author: Shayne Cox Gad

Publisher: John Wiley & Sons

Published: 2016-11-18

Total Pages: 918

ISBN-13: 1119097401

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This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition

Evaluation of Enzyme Inhibitors in Drug Discovery

Evaluation of Enzyme Inhibitors in Drug Discovery PDF

Author: Robert A. Copeland

Publisher: John Wiley & Sons

Published: 2005-04-01

Total Pages: 295

ISBN-13: 0471723266

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Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.

Pharmacy Student Survival Guide, 3E

Pharmacy Student Survival Guide, 3E PDF

Author: Ruth E. Nemire

Publisher: McGraw Hill Professional

Published: 2015-02-10

Total Pages: 619

ISBN-13: 0071829067

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A handbook that you will refer to throughout your entire pharmacy education! Pharmacy Student Survival Guide is a one-of-a-kind roadmap for excelling in pharmacy practice courses. A unique combination calculations, kinetics, drug information, medical terminology, and laboratory data book all in one, the Guide helps you organize case information, improve problem-solving skills, learn terminology, and impress faculty during rounds. Pharmacy Student Survival Guide is presented in three sections that span the entire pharmacy curriculum: Systems and Expectations covering etiquette, ethics, communication, monitoring patients, and the function of a medical team Patient Care Tool Box covering medical terminology, pharmacokinetics, laboratory data, and physical assessment Topics in Pharmacy Practice addressing the practice of community and institutional pharmacy, the pharmacists as drug information specialist, managed care, public health, and global pharmacy Valuable for both introductory and advanced practice courses, Pharmacy Student Survival Guide is the one book every pharmacy student must own.

Drug Discovery and Evaluation

Drug Discovery and Evaluation PDF

Author: Hans G. Vogel

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 790

ISBN-13: 366203333X

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This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.