Emerging technologies for musculoskeletal disease modeling and regenerative medicine
Author: Andrea Vernengo
Publisher: Frontiers Media SA
Published: 2023-09-06
Total Pages: 407
ISBN-13: 2832533124
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Regenerative Medicine Technology
Author: Sean V. Murphy
Publisher: CRC Press
Published: 2016-11-30
Total Pages: 459
ISBN-13: 1498711928
DOWNLOAD EBOOK →Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.
Selected Health Conditions and Likelihood of Improvement with Treatment
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2020-07-12
Total Pages: 319
ISBN-13: 0309670950
DOWNLOAD EBOOK →The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.
Principles of Regenerative Medicine
Author: Anthony Atala
Publisher: Academic Press
Published: 2010-12-16
Total Pages: 1203
ISBN-13: 0123814235
DOWNLOAD EBOOK →Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
Principles of Tissue Engineering
Author: Robert Lanza
Publisher: Elsevier
Published: 2000-05-16
Total Pages: 1039
ISBN-13: 008053967X
DOWNLOAD EBOOK →The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others
Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles
Author: Venkatram Prasad Shastri
Publisher: Springer Science & Business Media
Published: 2010-08-14
Total Pages: 414
ISBN-13: 9048187885
DOWNLOAD EBOOK →This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.
Mesenchymal Stem Cell in Veterinary Sciences
Author: Mudasir Bashir Gugjoo
Publisher: Springer Nature
Published: 2020-11-09
Total Pages: 347
ISBN-13: 9811560374
DOWNLOAD EBOOK →This book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.
Engineering Strategies for Regenerative Medicine
Author: Tiago G. Fernandes
Publisher: Academic Press
Published: 2019-11-14
Total Pages: 284
ISBN-13: 0128166703
DOWNLOAD EBOOK →Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry
Emerging Technologies In Biophysical Sciences: A World Scientific Reference (In 3 Volumes)
Author:
Publisher: World Scientific
Published: 2022-10-14
Total Pages: 1078
ISBN-13: 9811225699
DOWNLOAD EBOOK →Volume 1:Biofabrication aims to produce artificially manufactured tissues and organs, potentially revolutionizing conventional paradigm of clinical practice in treating diseases and extending the life span and quality of human beings. In this volume, we invite notable experts in the field of biofabrication and biomanufacturing to summarize recent rapid progress in this field from multifaceted aspects covering biofabrication techniques and building materials such as scaffold and living cells. Specifically, a focus is placed on a variety of techniques derived from 3D bioprinting and bioassembly strategies, such as acoustic assembly and electrofabrication. Moreover, principles and strategies for choosing hydrogels and polymers for biofabrication are also heavily discussed. Overall, this book creates a good opportunity for undergraduate and postgraduate students as well as bioengineers and medical researchers who wish to gain a fundamental understanding of current status and future trends in biofabrication and biomanufacturing.Volume 2:Infertility has become a significant psychosocial burden affecting the lives of couples who cannot reproduce naturally. Advanced reproductive technologies (ARTs) are being developed to treat infertility. This handbook explores significant development of ARTs for fertility testing, selection of sperm, oocyte and embryo, reproductive monitors, automation in embryology, and fertility preservation. This volume provides a comprehensive overview of the myriad of emerging technologies and systems that are being utilized or will be utilized in near future in reproductive clinics. Overall this book creates a good opportunity for undergraduate and postgraduate students as well as scientists and medical researchers who wish to gain fundamental understanding of current status and future trends in fertility and reproductive medicine.Volume 3:Healthcare industry has a notable paradigm transition from centralized care to the point-of-care (POC). During this metamorphosis, a number of new technologies and strategies have been adapted to the current practice, addressing the existing challenges in the fields of medicine and biology. All the efforts aim to improve the clinical management and the effectiveness and quality of care. In particular, diagnostics has pivotal roles in guiding clinical management for the most effective treatment to control and cure the disease. In contrast to the existing diagnostic strategies employing bulky-sized tools, expensive infrastructure, laborious protocols, and lengthy processing steps, the contribution of biosensors to current healthcare system, especially to diagnostics, is paramount. The unprecedented and admirable characteristics of biosensing strategies have expanded our knowledge on medicine and biology by harmonizing materials science, chemistry, physics, and engineering. We believe that biosensors applied to disease diagnostics will not only garner more attention in clinical research to decipher disease biology and mechanism, and also, stimulate innovative perspectives in artificial intelligence (AI) and internet of things (IoT) synergistically, thereby their more facile adaptation to daily-use. Overall this book creates a good opportunity for undergraduate and postgraduate students as well as scientists and medical researchers who wish to gain fundamental understanding of current status and future trends in diagnostic technologies.
Stem Cells and Regenerative Medicine
Author: Walter C. Low
Publisher: World Scientific
Published: 2008
Total Pages: 571
ISBN-13: 9812775773
DOWNLOAD EBOOK →The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.
