Handbook on Immunosenescence

Handbook on Immunosenescence PDF

Author: Tamas Fulop

Publisher: Springer Science & Business Media

Published: 2009-02-27

Total Pages: 1693

ISBN-13: 1402090633

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This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Sex and Gender Differences in Infection and Treatments for Infectious Diseases

Sex and Gender Differences in Infection and Treatments for Infectious Diseases PDF

Author: Sabra L. Klein

Publisher: Springer Nature

Published: 2023-09-11

Total Pages: 282

ISBN-13: 3031351398

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This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).

Oncology Rehabilitation E-Book

Oncology Rehabilitation E-Book PDF

Author: Deborah Doherty

Publisher: Elsevier Health Sciences

Published: 2022-07-23

Total Pages: 884

ISBN-13: 0323810888

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Coverage of physical therapy patient management includes acute care, outpatient, and multidisciplinary clinical settings, along with in-depth therapeutic management interventions. Content on the continuum of cancer care addresses the primordial, primary, secondary, tertiary, and quaternary stages in prevention and treatment. Focus on clinicians includes the professional roles, responsibilities, self-care, and values of the oncology rehabilitation clinician as an integral member of the cancer care team. Information on inseparable contextual factors helps in dealing with administrative infrastructure and support, advocacy, payment, and reimbursement of rehabilitation as well as public policy. Evidence Summary and Key Points boxes highlight important information for quick, at-a-glance reference. Clinical case studies and review questions enhance your critical thinking skills and help you prepare for board certification, specialty practice, and/or residency. Enhanced eBook version— included with print purchase— allows you to access all of the text, figures, and references from the book on a variety of devices. Resources in the eBook include videos, board-review questions, case studies, and a curriculum map to highlight and demonstrate the correlation to the requirements for Oncology Rehabilitation Residency programs and the board certification exam. Guidebook approach provides immediate, meaningful application for the practicing oncology rehabilitation clinician.

Sex Hormones and Immunity to Infection

Sex Hormones and Immunity to Infection PDF

Author: Sabra L. Klein

Publisher: Springer Science & Business Media

Published: 2009-10-22

Total Pages: 323

ISBN-13: 3642021557

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Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide PDF

Author: Yogesh Dwivedi

Publisher: CRC Press

Published: 2012-06-25

Total Pages: 485

ISBN-13: 143983881X

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With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Tumor Microenvironment

Tumor Microenvironment PDF

Author: Alexander Birbrair

Publisher: Springer Nature

Published: 2021-10-18

Total Pages: 548

ISBN-13: 3030731197

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This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Ultimate Immunity

Ultimate Immunity PDF

Author: Elson Haas

Publisher: Rodale

Published: 2015-10-06

Total Pages: 354

ISBN-13: 162336390X

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If you think your immune system is a simple thing that only helps you fight off colds and flus, think again. It is in fact a highly complex, protective, and intelligent system that can bolster health and healing from head to toe. However, a number of factors--from illnesses you've had to the medications you take to the toxins you interact with on a daily basis--can throw your immune system off balance, resulting in excessive inflammation that worsens allergies and pain and even leads to serious chronic conditions. The good news: You can feed, nourish, and train your immune system to work better for you. In Ultimate Immunity, health experts Drs. Elson Haas and Sondra Barrett will lead you through a unique plan aimed at balancing, amplifying, and managing your intricate immune health. With a 5-day healing diet to reset the immune system, delicious foods and recipes to nourish immune cells, and testimonials from people who used these methods to overcome chronic pain and health issues, Ultimate Immunity is the guidebook to total health.

Testosterone and Aging

Testosterone and Aging PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2004-03-12

Total Pages: 239

ISBN-13: 0309090636

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Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an "antiaging tonic," testosterone's reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.