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Ebola’s Evolution

Author: Michael B. A. Oldstone

Publisher: Archway Publishing

Published: 2021-06-04

Total Pages: 137

ISBN-13: 1665702494

This book provides an intimate portrait of multiple outbreaks of Ebola in Africa and reveals how the results of that experience can help us fight COVID-19. Michael B.A. Oldstone, who led the Viral-Immunobiology Laboratory at the Scripps Research Institute worked with Ebola, teams up with Madeleine Rose Oldstone to give a detailed account of the 2013-2016 and 2018-2020 Ebola outbreaks. The authors trace the origin of the disease, its spread like a tsunami thru Guinea, Sierra Leone and Liberia, the collapse of economies, and the development of anti-viral therapies against Ebola. They compare the outbreaks of one of the world’s deadliest viruses with today’s struggle to overcome the COVID-19 pandemic. You will gain intimate knowledge of a deadly pathogen that devastated a region of the world that lacks resources to fight it, and learn why the world was unprepared for the Ebola outbreak. You will meet people who fought heroically with limited resources, including Sheik Kahn who died fighting Ebola and was declared a national hero by the Sierra Leone government, Pardis Sabeti, a geneticist working in infectious diseases from Harvard and MIT who was named “Scientist of the Year” by Time magazine, and Robert Garry, who headed the fight against viral hemorrhagic diseases and kept the White House and the press informed. Sabeti and Garry worked with Oldstone and provided information about the outbreak to the authors, making the narrative particularly incisive and timely. Ebola’s Evolution will give you a fast paced, detailed, and fascinating picture of a feared disease that killed thousands of people and threatening to become a global pandemic before it was stopped.

Ebola

Author: James Lyons-Weiler

Publisher: World Scientific

Published: 2015-05-27

Total Pages: 248

ISBN-13: 9814675946

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The book is a narrative of the unfolding of the Ebola virus disease outbreak from a scientific view point. The author provides an analysis of the scientific basis of public health policies that have influenced the public's, and the medical community's, abilities to understand the virus and the disease. This is done in the context of providing insights into the biology of the virus, and exploring open questions, including its likely modes of transmission. The author has included citations from the scientific literature and the press, as well as quotes from expert interviews. The book will help sort out the fact from fiction, given the confusion that arose after the virus arrived in the US. The author used his objective research skills and knowledge of evolutionary genetics and molecular biology to find out what was known, and what questions remained unanswered, and even what questions remained unasked. Written in an accessible style, it is intended for the educated general public, scientists, policy makers, health care workers, and politicians. It delves into the problems of trying to derive a logic-based understanding of a highly lethal emerging disease in 2014, when research funding cuts have gutted research institutions, and when public health institutions really were woefully unprepared. It is a highly distinct narrative analysis that is sure to stimulate new research and thinking in public policy. It will inform thousands of people of the nature of the virus, how it works, in terms they are likely to be able to understand. It will allow others to rapidly catch up with the story of Ebola. Contents:Origins of the EpidemicHow Well Do We Understand the 2014 Ebolavirus?Ways in Which Ebola Guinea May Differ from Past Outbreaks: Evolution of Viral PhenotypesBiological Knowledge and Ebola Policy"How Cruel is That?"With Blinded EyesAre We Asking the Right Questions and Solving All the Right Problem(s)?Evolution is Real: Deadly Consequences of DogmaPromising TreatmentsPolicy AnalysisA Rational Analysis of Irrational Decisions, or Don't Fear the Reaper Readership: General public, scientists, policy makers, health care workers, and politicians. Key Features:This book delves into the problems of trying to derive a logic-based understanding of a highly lethal emerging disease in 2014, when research funding cuts have gutted us institutions, and when public health institutions really were woefully unpreparedIt is a highly distinct narrative analysis that is sure to stimulate new research and thinking in public policyIt will inform thousands of people on the nature of the virus, how it works, in terms they are likely to be able to understandIt will allow others to rapidly catch up with the story of ebolaKeywords:Ebola;Clinical Trials;Current Events;Viral Research;Infectious Diseases;Public Health;Policy;Africa;Epidemiology;DiagnosticsReview: "This is a reasonably useful book for those with a science background seeking an early insight to the latest ebola outbreak. With topicality being this book's big plus point, it finds a place on a number of university library shelves as well as on the 'further reading' list of a number of courses." The Science Fact & Science Fiction Concatenation

Ebola's Evolution

Author: Michael B a Oldstone

Publisher: Archway Publishing

Published: 2021-06-04

Total Pages: 190

ISBN-13: 9781665702485

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This book provides an intimate portrait of multiple outbreaks of Ebola in Africa and reveals how the results of that experience can help us fight COVID-19. Michael B.A. Oldstone, who led the Viral-Immunobiology Laboratory at the Scripps Research Institute worked with Ebola, teams up with Madeleine Rose Oldstone to give a detailed account of the 2013-2016 and 2018-2020 Ebola outbreaks. The authors trace the origin of the disease, its spread like a tsunami thru Guinea, Sierra Leone and Liberia, the collapse of economies, and the development of anti-viral therapies against Ebola. They compare the outbreaks of one of the world's deadliest viruses with today's struggle to overcome the COVID-19 pandemic. You will gain intimate knowledge of a deadly pathogen that devastated a region of the world that lacks resources to fight it, and learn why the world was unprepared for the Ebola outbreak. You will meet people who fought heroically with limited resources, including Sheik Kahn who died fighting Ebola and was declared a national hero by the Sierra Leone government, Pardis Sabeti, a geneticist working in infectious diseases from Harvard and MIT who was named "Scientist of the Year" by Time magazine, and Robert Garry, who headed the fight against viral hemorrhagic diseases and kept the White House and the press informed. Sabeti and Garry worked with Oldstone and provided information about the outbreak to the authors, making the narrative particularly incisive and timely. Ebola's Evolution will give you a fast paced, detailed, and fascinating picture of a feared disease that killed thousands of people and threatening to become a global pandemic before it was stopped.

Ebola and Marburg Viruses

Author: Hans-Dieter Klenk

Publisher: Garland Science

Published: 2004

Total Pages: 392

ISBN-13: 9780954523237

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The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

Ebola: the History of the Virus and Its Outbreaks

Author: Charles River Editors

Publisher: Createspace Independent Publishing Platform

Published: 2017-10-16

Total Pages: 70

ISBN-13: 9781978314627

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*Includes pictures *Includes accounts written by doctors, scientists, and survivors about the history and effects of the virus *Includes a bibliography for further reading "The Ebola epidemic ravaging parts of West Africa is the most severe acute public health emergency seen in modern times. Never before in recorded history has a biosafety level four pathogen infected so many people so quickly, over such a broad geographical area, for so long." - World Health Organization, September 2014 It has long been a maxim that it is easy to forget when one is at war who the enemy really is, and that can certainly be said for the Ebola virus, which recently catapulted into headlines and instantly became the most feared disease in the world. In the case of the fight against Ebola, the enemy is not the person who has contracted the disease, nor is it the region where the virus has flourished. The enemy is a microscopic virus that, when seen under sufficient magnification, looks like a piece of loosely knotted rope. While a picture of Ebola under a microscope might look innocuous, it is a living organism that can be killed, but if it is not, it will multiply and evolve much like any other organism, including the human beings it so often kills. Despite the fact Ebola has been notorious for nearly 40 years, its ability to hide and change with the times has made its origins murky and left scientists without a vaccine. The World Health Organization (WHO) was able to identify the previously unknown disease after an outbreak in Sudan that killed a majority of the infected victims in 1976, and a doctor graphically described its effects later that year: "The illness is characterized with a high temperature of about 39�C [102�F], hematemesis, diarrhea with blood, retrosternal abdominal pain, prostration with 'heavy' articulations, and rapid evolution death after a mean of three days." Ultimately named after the Ebola River, the virus was a strain of the Marburg virus, and when it struck various nations in Africa from 1976-2003, it had incredibly high mortality rates and left hundreds dead in places like Zaire, Uganda, and the Democratic Republic of Congo. Most recently, a massive outbreak of Ebola began in Guinea and hit Liberia, where it has left thousands dead and ravaged local economies. All the while, the WHO conceded, "Countries affected to date simply do not have the capacity to manage an outbreak of this size and complexity on their own. I urge the international community to provide this support on the most urgent basis possible." In the meantime, the disease has trickled out to other nations, including the United States, and as of October 2014, there has been a scramble to isolate potential victims and race towards developing a vaccine. Ebola: The History of the Disease and Its Outbreaks looks at the origins of the disease and explains its causes, symptoms, and effects while discussing the current outbreak and previous ones. Along with pictures and a bibliography, you will learn about the Ebola virus like never before, in no time at all.

Virusphere

Author: Frank Ryan

Publisher: William Collins

Published: 2020-03-19

Total Pages: 288

ISBN-13: 9780008296704

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In 1993 a previously healthy young man was drowning in the middle of a desert, in fluids produced by his own lungs. This was the beginning of the terrifying Sin Nombre hantavirus epidemic and the start of a scientific journey that would forever change our understanding of what it means to be human. After witnessing the Sin Nombre outbreak, Dr Frank Ryan began researching viral evolution and was astonished to discover that it's inextricable from the evolution of all life on Earth. From AIDS and Ebola to the common cold, Ryan explores the role of the virus within every ecosystem on the planet. His gripping conclusions shed new light on the natural world, proving that what doesn't kill you really does make you (and your species) stronger.

Virusphere

Author: Frank Ryan

Publisher: Rowman & Littlefield

Published: 2020-02-01

Total Pages: 289

ISBN-13: 1633886050

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A fascinating and long overdue examination of viruses - from what they are and what they do, to the vital role they have played in human history.What are viruses? Do they rely on genes, like all other forms of life? Do they follow the same patterns of evolution as plants and animals?Dr. Frank Ryan answers these questions and many more in a sweeping tour of illnesses caused by viruses. He examines the common cold, measles, chicken pox, herpes, mumps, and rubella, as well as less familiar maladies, such as rabies, "breakbone fever," hemorrhagic fevers like Ebola, and virus-induced cancers. Along the way, readers will learn about the behaviors of viruses and what drives them to infect a human host. Ryan explains the role of viruses in the evolution of life, revealing how viruses have changed us at the most intimate level, helping to make us quintessentially human.

The Hot Zone

Author: Richard Preston

Publisher: Anchor

Published: 1995

Total Pages: 450

ISBN-13: 0385479565

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The virus kills nine out of ten of its victims. Its effects are so quick and so gruesome that even biohazard experts are terrified. It is airborne, it is extremely contagious, and it is about to burn through the suburbs of Washington, D.C. Is there any way to stop it? This doomsday scenario confronted a biohazard SWAT team struggling in secret to stop the outbreak of an exotic "hot" virus at an Army research facility outside Washington. "The Hot Zone" tells the dramatic story of their dangerous race against time, along with an alarming account of how previously unknown viruses that have lived undetected in the rain forest for eons are now entering human populations. From the airlocked confines of a biosafety level 4 military lab, to an airliner over Kenya carrying a passenger dissolving into a human virus bomb, to a deserted jungle cave alive with deadly virus, THE HOT ZONE is a non-fiction thriller like no other. "The Andromeda Strain" was fiction--- "this is real!"

Ebola: The Natural and Human History of a Deadly Virus

Author: David Quammen

Publisher: W. W. Norton & Company

Published: 2014-10-20

Total Pages: 153

ISBN-13: 0393351564

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“A frightening and fascinating masterpiece of science reporting that reads like a detective story.” —Walter Isaacson In 1976 a deadly virus emerged from the Congo forest. As swiftly as it came, it disappeared, leaving no trace. Over the four decades since, Ebola has emerged sporadically, each time to devastating effect. It can kill up to 90 percent of its victims. In between these outbreaks, it is untraceable, hiding deep in the jungle. The search is on to find Ebola’s elusive host animal. And until we find it, Ebola will continue to strike. Acclaimed science writer and explorer David Quammen first came near the virus while he was traveling in the jungles of Gabon, accompanied by local men whose village had been devastated by a recent outbreak. Here he tells the story of Ebola—its past, present, and its unknowable future. Extracted from Spillover by David Quammen, updated and with additional material.

The Ebola Epidemic in West Africa

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-12-30

Total Pages: 137

ISBN-13: 0309450063

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The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.