Drug Selectivity

Drug Selectivity PDF

Author: Norbert Handler

Publisher: John Wiley & Sons

Published: 2018-02-27

Total Pages: 538

ISBN-13: 3527335382

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The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

The Selectivity of Drugs

The Selectivity of Drugs PDF

Author: Adrien Albert

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 65

ISBN-13: 9400957343

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1. 1 What is Selectivity? purpose, and crop protective agent for the A biologically-active substance is said to be second, but there is no fundamental difference selective if it strongly affects certain cells with of principle in their mode of action. out causing any change in others, even when the Drug therapy has two, fundamentally two kinds of cells are close neighbours. In living opposed divisions. The first of these strives to organisms, there are many substances, often improve the action of one of the cell's natural quite small molecules, which have been chosen agents by modifying the molecule in order to for their specificity. This choice has been made localize or intensify its action. For instance, under the strong pressure of natural selection, the solubility can be decreased to make it form unhurried by any consideration of time. Such a deposit, or a change is made so that it becomes chemical compounds operate the metabolism a poorer fit on the naturally-occurring destruc of the cells and tissues, and ensure their health, tive enzyme. Both of these devices have proved survival, and reproduction. Important among useful in therapy, e. g. with steroid hormones. the smaller of these selective molecules are Such drugs, which seek to improve on Nature vitamins, coenzymes, hormones, neurotrans by performing more desirably, are called mitters, inorganic ions, nutritional fragments, agonists.

Receptor Data for Biological Experiments

Receptor Data for Biological Experiments PDF

Author: Henri N. Doods

Publisher: Taylor & Francis Group

Published: 1991

Total Pages: 300

ISBN-13:

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Provides comprehensive coverage of the most relevant knowledge on classification, localization and biological effects of receptor systems and/or enzymes.

In Silico Drug Design

In Silico Drug Design PDF

Author: Kunal Roy

Publisher: Academic Press

Published: 2019-02-12

Total Pages: 886

ISBN-13: 0128163771

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In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

Functional Selectivity of G Protein-Coupled Receptor Ligands

Functional Selectivity of G Protein-Coupled Receptor Ligands PDF

Author: Kim Neve

Publisher: Springer Science & Business Media

Published: 2009-02-27

Total Pages: 290

ISBN-13: 1603273352

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Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Clinical Pharmacology in Psychiatry

Clinical Pharmacology in Psychiatry PDF

Author: Svein G. Dahl

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 294

ISBN-13: 3642712886

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The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chicago (1979), Troms0 (1980), and Odense (1982). During the organization of the fourth meeting Earl became ill and had to relinquish his role as one of the principal organizers. It is safe to conclude that there was no better, or more professional, or more efficient an organizer of scientific meetings in the field of neuropharmacology and psychiatry than Earl U sdin, and it was quite a task for the remaining organizers to fill the void left when he withdrew from this one. Those of us who have organized previous meetings with Earl were struck by how much more difficult our work became without him. This obviously speaks well for his subtle (and at times not so subtle) organizational skills. Nevertheless, in Earl's memory the organizers proceeded to invite a group of internationally renowned neuropsychopharmacologists to address the problem of selectivity in psychotropic drug action and to try to reconcile the amazing advances in basic preclinical neuropsychopharmacology with the problem of clinical specificity encountered by the psychiatrist.

Anesthetic Pharmacology

Anesthetic Pharmacology PDF

Author: Alex S. Evers

Publisher: Cambridge University Press

Published: 2011-03-10

Total Pages: 2902

ISBN-13: 1139497022

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In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

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