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Diversity of Selenium Functions in Health and Disease

Author: Regina Brigelius-Flohe

Publisher: CRC Press

Published: 2015-08-14

Total Pages: 410

ISBN-13: 1482251272

Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to

The Role of Selenium in Health and Disease

Author: Catherine Méplan

Publisher: MDPI

Published: 2020-12-06

Total Pages: 170

ISBN-13: 3039361465

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“Role of selenium in health and disease”. This book contains ten articles covering recent advances in our understanding of the relationship between the essential micronutrient selenium and human health and disease. Taken together, these articles strengthen the evidence showing that selenium, as a constituent of selenoproteins, is central to biological stress responses and mechanisms commonly altered in most complex disorders. Relevant to public health concerns, this book also emphasizes the U-shaped dose-response relationship between selenium concentration and disease risk across diverse populations from Europe [articles 2,3,6], the Middle East and North Africa [9], and Taiwan [5]. This highlights the importance of personalized nutrition strategies targeted at individuals with increased risk of disease and low selenium intake. The mechanisms by which selenium status, selenoprotein expression, and inherited genetic variations in the selenium pathway interact to affect molecular pathways involved in disease development are explored in human cohorts [2,3,5-7], and in animal [4] and in vitro models [8]. Furthermore, some reports identified novel potential biomarkers of disease risk and prognosis within the selenium pathway that could further our understanding of many chronic diseases [2,3]. Overall, this book broadens our understanding of the role of selenium in chronic diseases, and provides new directions for future preventative approaches.

The Role of Selenium in Health and Disease

Author: Catherine Méplan

Publisher:

Published: 2020

Total Pages: 170

ISBN-13: 9783039361472

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Selenium

Author: Dolph L. Hatfield

Publisher: Springer

Published: 2016-09-15

Total Pages: 638

ISBN-13: 3319412833

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In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

The Role of Selenium in Nutrition

Author: Gerald F. Jr. Combs

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 545

ISBN-13: 0323146538

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The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.

Selenium

Author: Dolph L. Hatfield

Publisher: Springer

Published: 2006-07-20

Total Pages: 0

ISBN-13: 9780387338262

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This book examines the molecular biology of selenium and how this element makes its way into protein. The role of this element in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders is explored in the text. The Second Edition outlines discoveries since the book was first introduced in 2001. Chapter updates have been written by investigators who have made important contributions to the field.

Selenium

Author: Dolph L. Hatfield

Publisher: Springer Science & Business Media

Published: 2011-11-13

Total Pages: 596

ISBN-13: 1461410258

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Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2000-08-27

Total Pages: 530

ISBN-13: 0309069491

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This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.

Trace Elements and Minerals in Health and Longevity

Author: Marco Malavolta

Publisher: Springer

Published: 2018-11-13

Total Pages: 328

ISBN-13: 3030037428

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This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, and e) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals

Author: James F Collins

Publisher: Academic Press

Published: 2016-09-14

Total Pages: 576

ISBN-13: 0128023767

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Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc. In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world. Presents the only scientific reference to cover all of the nutritionally relevant essential major and trace minerals Provides a broad introductory chapter on each mineral to give readers valuable background and context Clarifies the cellular and molecular aspects of each mineral and its genetic and genomic aspects Includes coverage of all nutritionally relevant minerals—essential major trace minerals and ultra-trace minerals Underscores the important interactions between minerals so readers learn how metabolism of one mineral influences another