-PDF Download- Cytokines Stress And Depression EBOOK

Cytokines, Stress, and Depression

Author: Robert Dantzer

Publisher: Springer Science & Business Media

Published: 1999-07-31

Total Pages: 334

ISBN-13: 0306461358

Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

Cytokines, Stress, and Depression

Author: Robert Dantzer

Publisher: Springer Science & Business Media

Published: 2007-11-23

Total Pages: 335

ISBN-13: 058537970X

DOWNLOAD EBOOK →

Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Author: Robert Dantzer

Publisher: Springer

Published: 2016-12-28

Total Pages: 357

ISBN-13: 3319511521

DOWNLOAD EBOOK →

Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Stress Challenges and Immunity in Space

Author: Alexander Choukèr

Publisher: Springer Nature

Published: 2019-11-27

Total Pages: 756

ISBN-13: 3030169960

DOWNLOAD EBOOK →

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Inflammation and Immunity in Depression

Author: Bernhard Baune

Publisher: Academic Press

Published: 2018-05-23

Total Pages: 636

ISBN-13: 0128110740

DOWNLOAD EBOOK →

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Handbook of Socioeconomic Determinants of Occupational Health

Author: Töres Theorell

Publisher: Springer Nature

Published: 2020-08-12

Total Pages: 704

ISBN-13: 3030314383

DOWNLOAD EBOOK →

This anthology provides readers of scientific literature on socioeconomic factors and working conditions with the newest knowledge in this field. Since our world is subjected to constant change in accelerating speed, scientific reviews and updates are needed. Fortunately, research methodology in epidemiology, physiology, psychology and sociology is also developing rapidly and therefore the scientific community can provide politicians and policy makers with increasingly sophisticated and exact descriptions of societal factors in relation to work. The anthology starts in the macro level sphere – with international perspectives and reviews related to working conditions in relation to political change (the fall of the Soviet Union) gender, age, precarious employment, national economy and retirement. Two chapters relate to national policies and activities in international organizations. The second part of the book relates to the meso level sphere – with reviews on social patterns in distributions of psychosocial and physical risks at work in general as well as reviews on noise, shift work, under/overemployment, occupational physical activity, job intensity (which may be a particularly important problem in low income countries), digitization in modern work, climate change, childhood determinants of occupational health in adult years and theoretical models currently used in occupational epidemiology - demand/control, effort/reward, organizational justice, psychosocial safety climate, conflicts, bullying/harassment. This part of the book ends with two chapters on interventions (one chapter on the use of cultural interventions and one on interventions and their evaluation in general) and two chapters on financial aspects of poor/good work environments and evaluations of interventions. In the third part of the book the micro level is addressed. Here mechanisms translating working conditions into physiology are discussed. This starts in general theory relating basic theories regarding energy storage and release to psychosocial theory (extension of demand control theory). It also includes regeneration physiology, autonomic nervous system function, immunology and adverse behaviour. Sections in the Handbook: Macro-level determinants of occupational health: Akizumi Tsutsumi, Meso-level determinants of occupational health: Morten Wahrendorf and Jian Li, Micro-level determinants of occupational health: Bradley J. Wright

Immuno-Psychiatry

Author: Michael Berk

Publisher: Springer Nature

Published: 2021-08-14

Total Pages: 438

ISBN-13: 303071229X

DOWNLOAD EBOOK →

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Clinical Psychometrics

Author: Per Bech

Publisher: John Wiley & Sons

Published: 2012-09-24

Total Pages: 168

ISBN-13: 1118511824

DOWNLOAD EBOOK →

Clinical Psychometrics is an introduction to the long-term attempt to measure the psychiatric dimension of dementia, schizophrenia, mania, depression, anxiety, neuroticism, extraversion/introversion and health-related quality of life. The two psychometric procedures, classical factor analysis and modern item-response models, are presented for readers without any requirement for particular mathematical or statistical knowledge. The book is unique in this attempt and provides helpful background information for the dimensional approach that is being used in the forthcoming updates to the diagnostic classification systems, ICD-11 and DSM-5. The book is written for everyone who is interested in the origins and development of modern psychiatry, and who wants to be familiar with its practical possibilities; how it is possible to compare different individuals with each other, how one may determine the boundary between what is normal and what is disease, or how one may assess the clinical effect of the various forms of treatment, available to present day psychiatry.

Cytokines in the Nervous System

Author: Nancy J. Rothwell

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 216

ISBN-13: 1461596955

DOWNLOAD EBOOK →

The Oxford Handbook of Stress and Mental Health

Author: Kate L. Harkness

Publisher: Oxford University Press, USA

Published: 2020

Total Pages: 769

ISBN-13: 0190681772

DOWNLOAD EBOOK →

This handbook is currently in development, with individual articles publishing online in advance of print publication. At this time, we cannot add information about unpublished articles in this handbook, however the table of contents will continue to grow as additional articles pass through the review process and are added to the site. Please note that the online publication date for this handbook is the date that the first article in the title was published online.