Hair Analysis in Clinical and Forensic Toxicology

Hair Analysis in Clinical and Forensic Toxicology PDF

Author: Pascal Kintz

Publisher: Academic Press

Published: 2015-06-25

Total Pages: 391

ISBN-13: 0128017104

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Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. Unites an international team of leading experts to provide an update on the cutting-edge advances in the toxicological analysis of hair Demonstrates toxicological techniques relating to a variety of scenarios and exposure types Ideal resource for the further study of the psychoactive substances, drug-facilitated crimes, ecotoxicology, analytical toxicology, occupational toxicology, toxicity testing, and forensic toxicology Includes detailed instructions for the collection, preparation, and handling of hair, and how to best interpret results

Clarke's Analytical Forensic Toxicology

Clarke's Analytical Forensic Toxicology PDF

Author: Gail Cooper

Publisher: Pharmaceutical Press

Published: 2013-05-28

Total Pages: 657

ISBN-13: 0857110543

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This invaluable textbook, written by international experts, covers all the main elements of forensic toxicology and analytical toxicology techniques as well as the important parts of pharmacokinetics, drug metabolism, and pharmacology in general, with a particular focus on drugs of abuse.

Analytical and Practical Aspects of Drug Testing in Hair

Analytical and Practical Aspects of Drug Testing in Hair PDF

Author: Pascal Kintz

Publisher: CRC Press

Published: 2006-08-30

Total Pages: 382

ISBN-13: 1420006193

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Many advances have been made since the publication of Drug Testing in Hair. The mid-1990s witnessed the progress in cannabis detection while the late 1990s focused on benzodiazepines detection and the applications in doping control. In more recent years, toxicologists centered on the detection in hair of a single exposure and the related applicatio

Detection of Drugs and Their Metabolites in Oral Fluid

Detection of Drugs and Their Metabolites in Oral Fluid PDF

Author: Robert M. White

Publisher: Elsevier

Published: 2018-02-23

Total Pages: 141

ISBN-13: 012814596X

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Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing Describes drugs and drug classes that can be tested, along with useful information on a patient/donor’s drug status

Karch's Drug Abuse Handbook

Karch's Drug Abuse Handbook PDF

Author: Steven Karch

Publisher: CRC Press

Published: 2022-11-29

Total Pages: 671

ISBN-13: 1420095005

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Karch’s Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices. For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology PDF

Author: Seth Kwabena Amponsah

Publisher: Springer Nature

Published: 2022-10-25

Total Pages: 384

ISBN-13: 3031123980

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This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Drug Testing in Alternate Biological Specimens

Drug Testing in Alternate Biological Specimens PDF

Author: Amanda J. Jenkins

Publisher: Springer Science & Business Media

Published: 2008-02-10

Total Pages: 186

ISBN-13: 1597453188

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Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today. Chapters focus specifically on the application of these practices to drugs of abuse. The up-to-date information provided is complemented with thorough references.

Instrumental Data for Drug Analysis, Second Edition

Instrumental Data for Drug Analysis, Second Edition PDF

Author: Terry Mills III

Publisher: CRC Press

Published: 2019-01-15

Total Pages: 828

ISBN-13: 1351090593

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Compiled with the most sophisticated chromatographic and spectrometric instruments available, this complete and self-contained seven-volume reference provides forensic, toxicology, and clinical laboratories with up-to-date information on 1,600 drugs and drug-related compounds-one of the largest collections of analytical data generated from a single source. Instrumental Data for Drug Analysis contains timely, quality data presented in a large, easily usable format. It is an essential reference in the libraries of all toxicology, analytical chemistry, and forensic specialists and laboratories.