Pharmacogenomics: A Primer for Clinicians

Pharmacogenomics: A Primer for Clinicians PDF

Author: Jerika T. Lam

Publisher: McGraw Hill Professional

Published: 2020-12-22

Total Pages: 186

ISBN-13: 1260457117

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An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.

A Pharmacology Primer

A Pharmacology Primer PDF

Author: Terry Kenakin

Publisher: Academic Press

Published: 2018-10-26

Total Pages: 488

ISBN-13: 0128139587

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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

The Art Therapists' Primer

The Art Therapists' Primer PDF

Author: Ellen G. Horovitz

Publisher: Charles C Thomas Publisher

Published: 2020-07-01

Total Pages: 411

ISBN-13: 0398093385

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Doctor Ellen G. Horovitz shares over 40 years of experience as she transliterates evidence-based art therapy into medical terminology. This revised and updated Third Edition spells out the how-to's behind producing art therapy assessments, process notes, significant sessions, objectives and modalities, termination summaries and internet-based assessments into translatable documentation, designed to dovetail within an interdisciplinary medical model. In addition, this third edition emphasizes information on how to use psychological applications and art therapy based assessments to ensure best practices and efficacy of patient care. This step-by-step methodology fashions these reports, placing art therapy on equal footing with all mental health clinicians and generates records, which serve as points of departure for practitioners. This text is designed as a teaching tool that lays the foundation to enhance pertinent skills that are important to patient practice, including the armament to write up clinically-based reports that serve as a model for the field. Additionally, the practitioner is offered sample formats, legends and abbreviations of clinical and psychiatric terms, guidelines for recordable events, instructions of writing up objectives, modalities, and treatment goals as well as training on composing progress versus process notes. The Appendices provides a wealth of information and forms to use in one's clinical practice. This must-have reference manual amasses information that will serve as a companion guide for every art therapist to formulate clinical reports, and it will aid patients toward their trajectory of wellness, recovery and, above all, health.

A Primer of Handling the Negative Therapeutic Reaction

A Primer of Handling the Negative Therapeutic Reaction PDF

Author: Jeffrey Seinfeld

Publisher: Jason Aronson

Published: 2002

Total Pages: 278

ISBN-13: 9780765703637

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In a negative therapeutic reaction the progress of treatment triggers a particular destructive dynamic in the patient. Initially, therapists considered it to be a result of the patient's pathology, but contemporary clinicians recognize that the therapist may significantly contribute to this process. Object relations clinicians see the individual as a social being that develops in relation to others whom the individual internalizes as good and bad objects. Jeffrey Seinfeld explores how an internal sabotaging self is identified with a rejecting object. This self is a reservoir of memories of how original caregivers rejected the child's needs, and the patient now expects the world to reject and disappoint her. If patients experience the therapist as a kind or caring person, they may feel that they are being lured into dependency and subsequent disappointment. Paradoxically, if patients feel attached to the therapist, this same attachment is experienced as a threatening dependency that must be destroyed. A relationship that could eventually strengthen the personality is rejected, and instead a negative reaction to the therapist and the therapeutic process is established. Jeffrey Seinfeld shows that in order for patients to heal, they must separate from the internal bad objects.This is often done with aggression against the therapist, who must be able to withstand the intense hostility, rage, and abuse of the patient. Only by surviving this aggression in the negative therapeutic reaction can the therapist allow the patient to integrate good and bad part objects in the transference. The therapist can eventually serve as a bridge in the integration of the divided good and bad selves and objects. Through case histories Seinfeld illustrates his way of entering into the patient's internal world. By helping patients understand the transference of their internal objects, they begin to understand their own experience of self and others, which leads to character change.

A Primer for Emotionally Focused Individual Therapy (EFIT)

A Primer for Emotionally Focused Individual Therapy (EFIT) PDF

Author: Susan M. Johnson

Publisher: Routledge

Published: 2021-09-28

Total Pages: 148

ISBN-13: 1000462684

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From best-selling author, Susan M. Johnson, with over 1 million books sold worldwide! This essential text from the leading authority on Emotionally Focused Therapy, Susan M. Johnson, and colleague, T. Leanne Campbell, applies the key interventions of EFT to work with individuals, providing an overview and clinical guide to treating clients with depression, anxiety, and traumatic stress. Designed for therapists at all levels of expertise, Johnson and Campbell focus on introducing clinicians to EFIT interventions, techniques, and change processes in a highly accessible and practical format. The book begins by summarizing attachment theory and science – the theoretical basis of this model – together with the experiential approach to change in psychotherapy. Chapters describe the three stages of EFIT, macro-interventions, such as the EFIT Tango, and various micro-interventions through clinical exercises, case studies, and transcripts to demonstrate this model in practice with individuals, highlighting the unique benefits of EFT as a cross-modality approach for treating emotional disorders. With exercises interwoven throughout the text, this book is built to accompany in-person and online training, helping the practicing clinician offer targeted and empirically tested interventions that not only alleviate symptoms of distress but expand the client’s emotional balance, agency, and sense of self. As the next major extension of the EFT approach, this book will appeal to therapists already working with couples and families as well as those just beginning their professional journey. Psychotherapists, psychologists, counselors, social workers, and mental health workers will also find this book invaluable.

A Pharmacology Primer

A Pharmacology Primer PDF

Author: Terry Kenakin

Publisher: Elsevier

Published: 2010-07-26

Total Pages: 318

ISBN-13: 9780080465302

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The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. Over 30 new figures and tables More human interest information to provide readers with historical facts on pharmacology research New section on therapeutics to help identify diseaes and drug treatments New section on new biological concepts relevant to pharmacological research (i.e., systems biology) New study sections organized with ASPET and other international pharmacology organizations New coverage of pharmacokinetics and drug disposition

Clinical Precision Medicine

Clinical Precision Medicine PDF

Author: Judy S. Crabtree

Publisher: Academic Press

Published: 2019-11-15

Total Pages: 114

ISBN-13: 0128204028

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Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

A Primer for Beginning Psychotherapy

A Primer for Beginning Psychotherapy PDF

Author: William N. Goldstein

Publisher: Routledge

Published: 2013-01-11

Total Pages: 148

ISBN-13: 1135057613

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Designed especially for students and mental health professionals in the early stages of their careers, this primer is a practical guide to psychotherapy --

The Pharmacy Informatics Primer

The Pharmacy Informatics Primer PDF

Author: Doina Dumitru

Publisher: ASHP

Published: 2008-09-30

Total Pages: 265

ISBN-13: 1585282766

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The information technology revolution has fueled the demand in hospitals and health systems for accomplished experts who can help select, implement and maintain CPOE, BCMA, EHR and other systems. As the use of IT in healthcare expands and the complexity of medication therapy increases, there has been a correspondingly rapid growth in the practice of pharmacy informatics and a basic need for an understanding of key elements. The Pharmacy Informatics Primer provides a foundational understanding and offers “pearls of wisdom” for pharmacy professionals involved in informatics. This introductory resource outlines key concepts in understanding, developing, implementing, and maintaining clinical information and automation systems. This essential guide is designed for all pharmacists and covers an introduction to major concepts of informatics such as ePrescribing, CPOE, bar-coding, smart pumps, and the pharmacist’s role in EHR. Chapter features include key terms and definitions, and a comprehensive table of pearls, specific to each subject to present a clear understanding of all concepts.