Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition PDF

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

The Cerebral Circulation

The Cerebral Circulation PDF

Author: Marilyn J. Cipolla

Publisher: Biota Publishing

Published: 2016-07-28

Total Pages: 82

ISBN-13: 1615047239

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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Protean Power

Protean Power PDF

Author: Peter J. Katzenstein

Publisher: Cambridge University Press

Published: 2018-01-18

Total Pages: 383

ISBN-13: 1108425178

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Inquires into the role of the unexpected in world politics by examining the protean power effects of agile innovation and improvisation.

Shakespearean Negotiations

Shakespearean Negotiations PDF

Author: Stephen Greenblatt

Publisher: Univ of California Press

Published: 1988

Total Pages: 226

ISBN-13: 9780520061606

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Stephen Greenblatt has been at the center of a major shift in literary interpretation toward a critical method that situates cultural creation in history. Shakespearean Negotiations is a sustained and powerful exemplification of this innovative method, offering a new way of understanding the power of Shakespeare's achievement and, beyond this, an original analysis of cultural process.

The 48 Laws of Power

The 48 Laws of Power PDF

Author: Robert Greene

Publisher: Penguin

Published: 2023-10-31

Total Pages: 481

ISBN-13: 0670881465

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Amoral, cunning, ruthless, and instructive, this multi-million-copy New York Times bestseller is the definitive manual for anyone interested in gaining, observing, or defending against ultimate control – from the author of The Laws of Human Nature. In the book that People magazine proclaimed “beguiling” and “fascinating,” Robert Greene and Joost Elffers have distilled three thousand years of the history of power into 48 essential laws by drawing from the philosophies of Machiavelli, Sun Tzu, and Carl Von Clausewitz and also from the lives of figures ranging from Henry Kissinger to P.T. Barnum. Some laws teach the need for prudence (“Law 1: Never Outshine the Master”), others teach the value of confidence (“Law 28: Enter Action with Boldness”), and many recommend absolute self-preservation (“Law 15: Crush Your Enemy Totally”). Every law, though, has one thing in common: an interest in total domination. In a bold and arresting two-color package, The 48 Laws of Power is ideal whether your aim is conquest, self-defense, or simply to understand the rules of the game.

Circulation, Writing, and Rhetoric

Circulation, Writing, and Rhetoric PDF

Author: Laurie Gries

Publisher: University Press of Colorado

Published: 2018-04-15

Total Pages: 346

ISBN-13: 1607326744

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While it has long been understood that the circulation of discourse, bodies, artifacts, and ideas plays an important constitutive force in our cultures and communities, circulation, as a concept and a phenomenon, has been underexamined in studies of rhetoric and writing. In an effort to give circulation its rhetorical due, Circulation, Writing, and Rhetoric introduces a wide range of studies that foreground circulation in both theory and practice. Contributors to the volume specifically explore the connections between circulation and public rhetorics, urban studies, feminist rhetorics, digital communication, new materialism, and digital research. Circulation is a cultural-rhetorical process that impacts various ecologies, communities, and subjectivities in an ever-increasing globally networked environment. As made evident in this collection, circulation occurs in all forms of discursive production, from academic arguments to neoliberal policies to graffiti to tweets and bitcoins. Even in the case of tombstones, borrowed text achieves only partial stability before it is recirculated and transformed again. This communicative process is even more evident in the digital realm, the underlying infrastructures of which we have yet to fully understand. As public spaces become more and more saturated with circulating texts and images and as networked relations come to the center of rhetorical focus, Circulation, Writing, and Rhetoric will be a vital interdisciplinary resource for approaching the contemporary dynamics of rhetoric and writing. Contributors: Aaron Beveridge, Casey Boyle, Jim Brown, Naomi Clark, Dànielle Nicole DeVoss, Rebecca Dingo, Sidney I. Dobrin, Jay Dolmage, Dustin Edwards, Jessica Enoch, Tarez Samra Graban, Byron Hawk, Gerald Jackson, Gesa E. Kirsch, Heather Lang, Sean Morey, Jenny Rice, Thomas Rickert, Jim Ridolfo, Nathaniel A. Rivers, Jacqueline Jones Royster, Donnie Johnson Sackey, Michele Simmons, Dale M. Smith, Patricia Sullivan, John Tinnell, Kathleen Blake Yancey

The Rise and Fall of the Elites

The Rise and Fall of the Elites PDF

Author: Vilfredo Pareto

Publisher: Transaction Publishers

Published: 1991-01-01

Total Pages: 130

ISBN-13: 0887388728

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Combining a thorough introduction to the work of nineteenth-and early twentieth-century Italian social theorist Vilfredo Pareto with a highly readable English translation of Pareto's last monograph "Generalizations," originally published in 1920, this work illustrates how and why democratic forms of government undergo decay and are eventually reinvigorated. More than any other social scientist of his generation, Pareto offers a well-developed, articulate, and compelling theory of change based on a Newtonian vision of science and an engineering model of social equilibrium. This dynamic involves a shifting balance among the countervailing forces of centralization and decentralization of power, economic expansion and contraction, and liberalism versus traditionalism in public sentiment. By 1920, Pareto had developed a scheme for predicting shifts in magnitude of these forces and subsequent change in the character of society. This book will be of interest to students, teachers, or general readers interested in political science, sociology and late-nineteenth/ early-twentieth century social theory. Vilfredo Pareto (1848-1923) was a pioneer in the field of econometrics, but gained fame, most of it posthumous, through his contributions to sociology and political science. Though often claimed by activist-rightist groups and a contributor to fascist thinking, he avoided alignment with any political movement.

Power and Interdependence in Organizations

Power and Interdependence in Organizations PDF

Author: Dean Tjosvold

Publisher: Cambridge University Press

Published: 2009-02-26

Total Pages: 393

ISBN-13: 0521878594

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Capitalizing on significant developments in social science over the past twenty years, this book explores both the positive and negative aspects of power, identifying opportunities and threats. It shows how managers and employees can manage power in order to make it a constructive force in organizations.

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