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Natural Products for Cancer Chemoprevention

Author: John M. Pezzuto

Publisher: Springer Nature

Published: 2020-04-03

Total Pages: 639

ISBN-13: 3030398552

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author: Manish Kumar

Publisher: Springer Nature

Published: 2020-07-20

Total Pages: 344

ISBN-13: 9811559996

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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Cancer Chemoprevention

Author: Gary J. Kelloff

Publisher: Springer Science & Business Media

Published: 2008-08-17

Total Pages: 543

ISBN-13: 1592597688

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Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Cancer Chemoprevention

Author: Gary J. Kelloff

Publisher: Springer Science & Business Media

Published: 2004-06-04

Total Pages: 998

ISBN-13: 159259767X

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Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.

Chemoprevention of Cancer

Author: Daniel W. Nixon

Publisher: CRC Press

Published: 1994-11-08

Total Pages: 160

ISBN-13: 9780849368509

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Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Cancer Chemoprevention

Author: Raymond C. Bergan

Publisher: Springer

Published: 2001

Total Pages: 336

ISBN-13:

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Great advances were made in the pharmacologic-based treatment of cancer in prior decades. However, despite a marked increase in our understanding ofcell and molecular mechanisms underlying the neoplastic process, therapy for advanced disease remains limited. While the reasons for this are many, it is generally accepted that advanced neoplasms contain a relatively large number of genetic and molecularalterations contributingto the maintenanceofthe neoplastic process. Such a situation precludes easy pharmacologic intervention. However, our ability to detect cancer at an earlier stage, coupled with our increased understandingofcarcinogenesis, are propellingboth basic and clinical scientiststo pursue early intervention/chemopreventive approaches. This is based upon the notion that fewer molecularaberrations are presentearlyon inthedisease process. It also takes advantage ofthe fact that advances in both technology, and in the field ofcancer biology, coupled with a heightened vigilance, have increased our ability to detect early disease more readily. The chemopreventive approach is highly attractive for a number ofreasons. First, treatment ofpre-neoplastic, or early neoplastic, lesions would prevent the significant mobility and mortality associated with advanced neoplastic disorders.

Chemoprevention in Cancer Control

Author: Matti Hakama

Publisher:

Published: 1996

Total Pages: 164

ISBN-13:

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This book is a collection of discussions and presentations made by leading experts during a workshop to review the results of recent empirical studies on the effectiveness of chemopreventive agents on the reduction of cancer risk. The topics selected were intended to cover the main areas of research in this field over the last 5-10 years, as well as important issues concerning the design of research studies, cost-effectiveness of chemoprevention, and ethical concerns. A set of conclusions and recommendations are included to provide a guide to formulating future public health policy and research strategy.

Chemoprevention of Cancer

Author: H.-J. Senn

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 205

ISBN-13: 3642599451

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Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.

Cancer Chemoprevention

Author: Lee Wattenberg

Publisher: CRC Press

Published: 1992-08-20

Total Pages: 654

ISBN-13: 9780849347153

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The ultimate goal of cancer chemoprevention research and development is the identification of pharmaceutical or dietary constituents that will prevent cancer. Cancer Chemoprevention presents the proceedings of a large workshop on cancer chemoprevention that highlights the latest knowledge in the field, in addition to issues and ideas concerning future directions. Retinoids, sulfur compounds, and a large number of many naturally occurring cancer inhibitors in the diet are discussed, including green tea, garlic constituents, citrus fruit oils, and beans and seeds containing protease inhibitors. Compounds that may prevent the formation of carcinogens in food are covered, and the mechanisms by which chemical or dietary agencts produce cancer inhibitors are discussed.

Textbook of Cancer Epidemiology

Author: Hans-Olov Adami

Publisher: Oxford University Press

Published: 2008-02-27

Total Pages: 784

ISBN-13: 0199718636

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This superb text gives a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Part 1 provides an introduction to basic concepts in epidemiology, a description of the global burden of cancer, definitions and characterizations of the various measures used, and approaches used to reveal genetic determinants of cancer risk and integrate biologic markers in the epidemiogic research process. Part 2 contains chapters of uniform structure on over 20 types of cancer, providing clinical and pathological outlines, descriptive epidemiology, and a comprehensive account of risk factors and their etiological importance. Specific sections address somatic and germ cell mutations that play a role in the occurrence of particular forms of cancer.