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Natural Products for Cancer Chemoprevention

Author: John M. Pezzuto

Publisher: Springer Nature

Published: 2020-04-03

Total Pages: 639

ISBN-13: 3030398552

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Chemoprevention in Cancer Control

Author: Matti Hakama

Publisher:

Published: 1996

Total Pages: 164

ISBN-13:

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This book is a collection of discussions and presentations made by leading experts during a workshop to review the results of recent empirical studies on the effectiveness of chemopreventive agents on the reduction of cancer risk. The topics selected were intended to cover the main areas of research in this field over the last 5-10 years, as well as important issues concerning the design of research studies, cost-effectiveness of chemoprevention, and ethical concerns. A set of conclusions and recommendations are included to provide a guide to formulating future public health policy and research strategy.

Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2008

ISBN-13: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cancer Prevention II

Author: Hans-Jörg Senn

Publisher: Springer Science & Business Media

Published: 2008-11-28

Total Pages: 249

ISBN-13: 3540692975

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More than 180 participants and experts from 31 countries met for the fifth time in 10 years in St. Gallen, Switzerland for a 3-day conference to discuss important current issues of clinical cancer prevention. The meeting was again organized and co-sponsored by St. Gallen Oncology Conferences (SONK). While SONK has been extremely successful in organizing large international c- gresses on “Primary Therapy of Early Breast Cancer” as well as “Supportive Care in Cancer” for more than 20 years, the idea of promoting interdisciplinary, clinically oriented meetings on cancer prevention is a more recent and not yet generally accepted and w- comed concept in modern oncology. Since today’s medical expenses are soaring and me- cal research budgets are stagnating or even being cut, neither politicians nor industry is willing to risk an additional unpredictable channel of expenses, such as that demanded by clinical cancer prevention efforts! In Switzerland—and we fear in many other parts of the globe—some 97%–98% or even a greater percentage of health budgets is spent for curative and palliative/rehabilitative m- icine. Since a meager 2%–3% of national health budgets is for preventive medicine, even less than that proportion is specifically allocated for cancer prevention. When the money for “curing and caring” for the diseased populace runs short, there is likely not much left for partly controversial disease prevention in the (still) healthy part of the population.

Chemoprevention of Cancer

Author: Daniel W. Nixon

Publisher: CRC Press

Published: 1994-11-08

Total Pages: 160

ISBN-13: 9780849368509

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Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author: Manish Kumar

Publisher: Springer Nature

Published: 2020-07-20

Total Pages: 344

ISBN-13: 9811559996

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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Cancer Chemoprevention

Author: Gary J. Kelloff

Publisher: Springer Science & Business Media

Published: 2004-06-04

Total Pages: 998

ISBN-13: 159259767X

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Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.

Cancer Chemoprevention

Author: Gary J. Kelloff

Publisher: Springer Science & Business Media

Published: 2008-08-17

Total Pages: 537

ISBN-13: 1592597688

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Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Textbook of Cancer Epidemiology

Author: Hans-Olov Adami

Publisher: Oxford University Press

Published: 2018

Total Pages: 753

ISBN-13: 0190676825

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"Amid sweeping advances in the science and treatment of cancer, the Textbook of Cancer Epidemiology offers students and professionals a definitive, systematic resource for understanding the factors affecting all types of human cancer. This fully updated new edition offers an overview of epidemiology's key concepts and methods as they relate to cancer (including the merging potential of biomarkers) as well as site-specific chapters on individual cancers' natural history, pathology, descriptive epidemiology, and etiology. Taken together, these chapters forge connections between established science and the ongoing evolution of this dynamic field"--Back cover.

Cancer Chemoprevention

Author: Raymond C. Bergan

Publisher: Springer

Published: 2001

Total Pages: 336

ISBN-13:

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Great advances were made in the pharmacologic-based treatment of cancer in prior decades. However, despite a marked increase in our understanding ofcell and molecular mechanisms underlying the neoplastic process, therapy for advanced disease remains limited. While the reasons for this are many, it is generally accepted that advanced neoplasms contain a relatively large number of genetic and molecularalterations contributingto the maintenanceofthe neoplastic process. Such a situation precludes easy pharmacologic intervention. However, our ability to detect cancer at an earlier stage, coupled with our increased understandingofcarcinogenesis, are propellingboth basic and clinical scientiststo pursue early intervention/chemopreventive approaches. This is based upon the notion that fewer molecularaberrations are presentearlyon inthedisease process. It also takes advantage ofthe fact that advances in both technology, and in the field ofcancer biology, coupled with a heightened vigilance, have increased our ability to detect early disease more readily. The chemopreventive approach is highly attractive for a number ofreasons. First, treatment ofpre-neoplastic, or early neoplastic, lesions would prevent the significant mobility and mortality associated with advanced neoplastic disorders.