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Metal-Ligand Interactions
Author: N. Russo
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 595
ISBN-13: 940100191X
DOWNLOAD EBOOK →In September 2002, a NATO-ASI was held in Cetraro (CS), Italy on the theme of "Metal-Ligand Interactions in Molecular-, Nano-, Micro-, and Macro-systems in Complex Environments". This event has followed the previous ones held in the same place in 1991, 1994 and 1998. In the present and the previous schools a broad interdisciplinary cross-section of experimental and theoretical researchers, interested in a better understanding of metal-ligand interactions from different viewpoints, was linked together to exchange experience, to review the state-of-the-art, to indicate new techniques and methods, to explore new fields and perspectives. Particular emphasis was given to the problems related with the crossing from molecular systems to nano-, macro-and micro-scale materials and to the effects of the environment on the properties of the molecular systems. The school was organized around lectures and special research seminares given by leading experts in the following fields: • metal clusters • inorganic complexes and materials • surface phenomena • adsorption and catalysis • organic and bio-inorganic systems • ab initio theory • density functional theory • classical and quantum dynamics This volume contains the formal lectures and selected contributed papers and describes the main aspects and problems tackled during the 12 days of the event.
DNA-Ligand Interactions
Author: W. Guschlbauer
Publisher: Springer Science & Business Media
Published: 2013-06-29
Total Pages: 289
ISBN-13: 1468453831
DOWNLOAD EBOOK →This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.
DNA Interactions with Drugs and Other Small Ligands
Author: Marcio Santos Rocha
Publisher: Elsevier
Published: 2023-03-01
Total Pages: 268
ISBN-13: 0323993850
DOWNLOAD EBOOK →DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books. Presents a review of the fundamental knowledge, techniques and relevant information surrounding the field of DNA interactions with drugs and other ligands Provides a resource like no other book available Includes valuable information from the author who is a highly experienced researcher in the field
Metal-Ligand Interactions in Organic Chemistry and Biochemistry
Author: A. Pullman
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 397
ISBN-13: 9401011702
DOWNLOAD EBOOK →The 9th Jerusalem Symposium was dedicated to the memory of Professor Ernst David Bergmann. An imposing and deeply moving memorial session, chaired by Professor Ephraim Katzir, the President of the State of Is rael and a close friend of Professor Bergmann preceded the Symposium itself. During this session, Professor Bergmann's personality, scien tific achievements and contributions to the development of his country were described and praised, besides President Katzir, by Professor A. Dvoretzky, President of the Israel Academy of Sciences and Humanities, Professor D. Ginsburg, Dean of the Israel Institute of Technology in Haifa and the author of these lines. May I just quote short extracts from these speeches. President Katzir: "As we open this ninth in the series of symposia initiated in 1967, it is difficult for me as, I am sure, for many of Ernst Bergmann's friends, co-workers and students, to be here without him. He was not only a great scientist and a beloved teacher, he was one of the most important founders of science in this country. To him we owe many institutes and the establishment here of many branches of science. " Professor Dvoretzky: "Ernst Bergmann's greatness did not stem from one component overshadowing all the others. It was a multifaceted great ness consisting of the harmonious co~lescing of seemingly contrasting entities into a wonderful unity ••.
Protein-Ligand Interactions
Author: Hans-Joachim Böhm
Publisher: John Wiley & Sons
Published: 2006-03-06
Total Pages: 262
ISBN-13: 3527605517
DOWNLOAD EBOOK →The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Biophysics of DNA-Protein Interactions
Author: Mark C. Williams
Publisher: Springer Science & Business Media
Published: 2010-10-05
Total Pages: 354
ISBN-13: 0387928081
DOWNLOAD EBOOK →Depite the rapid expansion of the field of biophysics, there are very few books that comprehensively treat specific topics in this area. Recently, the field of single molecule biophysics has developed very quickly, and a few books specifically treating single molecule methods are beginning to appear. However, the promise of single molecule biophysics is to contribute to the understanding of specific fields of biology using new methods. This book would focus on the specific topic of the biophysics of DNA-protein interactions, and would include the use of new approaches, including both bulk methods as well as single molecule methods. This would make the book attractive to anyone working in the general area of DNA-protein interactions, which is of course a much wider market than just single molecule biophysicists or even biophysicists. The subject of the book will be the biophysics of DNA-protein interactions, and will include new methods and results that describe the physical mechanism by which proteins interact with DNA. For example, there has been much recent work on the mechanism by which proteins search for specific binding sites on DNA. A few chapters will be devoted to experiments and theory that shed light on this important problem. We will also cover proteins that alter DNA properties to facilitate interactions important for transcription or replication. Another section of the book will cover the biophysical mechanism by which motor proteins interact with DNA. Finally, we will cover larger protein-DNA complexes, such as replication forks, recombination complexes, DNA repair interactions, and their chromatin context.
DNA-targeting Molecules as Therapeutic Agents
Author: Michael J. Waring
Publisher: Royal Society of Chemistry
Published: 2018-03-12
Total Pages: 432
ISBN-13: 1782629920
DOWNLOAD EBOOK →There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Drug-DNA Interactions
Author: Kazuo Nakamoto
Publisher: John Wiley & Sons
Published: 2008-09-08
Total Pages: 475
ISBN-13: 0470369167
DOWNLOAD EBOOK →Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Specific Interaction and Biological Recognition Processes
Author: Zeno Simon
Publisher: CRC Press
Published: 1993-06-16
Total Pages: 356
ISBN-13: 9780849353987
DOWNLOAD EBOOK →Specific Interaction and Biological Recognition Processes is devoted to two major aspects of biological processes: specificity in biological recognition and the recognition processes themselves. Topics covered in specificity include the theoretical basis for specificity in biological recognition; the thermodynamic and chemical equilibrium background; and consideration of the relationship between size of combining sites and specificity. The use of semi-emperical potentials for calculating interaction energies and the potential of quantum chemistry methods for calculating receptor-effector affinities are also discussed. The various recognition processes described include DNA replication, transcription, translation, enzymatic reactions, transmembrane transport processes, mechanisms of action of hormones and other chemical messengers, and self-nonself recognition in immunology. Specific Interaction and Biological Recognition Processes will be a useful reference for molecular biologists, biochemists, enzymologists, immunologists oncologists, pharmaceutical researchers, and others interested in the topic.
