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Chasing Pain: The Search for a Neurobiological Mechanism

Author: Kenneth L. Casey

Publisher: Oxford University Press

Published: 2019-02-22

Total Pages: 208

ISBN-13: 0190920084

Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.

The Right to Pain Relief and Other Deep Roots of the Opioid Epidemic

Author: Mark Sullivan

Publisher: Oxford University Press

Published: 2023-01-24

Total Pages: 305

ISBN-13: 0197615724

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"Pain has always been a problem for Western Society, but not the same kind of problem. Until about 1500, pain was primarily understood as a religious problem. Pain and suffering challenged the truth of religious belief and the legitimacy of the Church: How could a just, merciful, and all-powerful God allow so much pain and suffering in the world? As our society became more secular over the next 300 years, pain came to be understood primarily as a social problem. This modernizing society aimed to create the best environment for human flourishing: How might human society be designed and regulated to reduce the pain and suffering of everyone to the minimum possible? At least since 1900, we have separated pain as a medical problem from the remainder of human suffering. We have aimed to reduce this problem to a minimum through medical treatment. This quest has led us to our opioid epidemic. To fully comprehend the limitations of this medical interpretation, we must appreciate how the medical explanation of pain grew out of earlier religious and social interpretations of pain"--

Encyclopedia of the Neurological Sciences

Author:

Publisher: Academic Press

Published: 2014-04-29

Total Pages: 4744

ISBN-13: 0123851580

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The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Anaesthesia, Intensive Care, and Pain Management for the Cancer Patient

Author: Paul Farquhar-Smith

Publisher: Oxford University Press

Published: 2011-07-21

Total Pages: 272

ISBN-13: 0199584648

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One in three people will develop some kind of cancer in their lifetime. The overall cancer incidence has increased by 25% since 1975. Anaesthetic involvement in hospital interactions has been estimated at around 75%, and so anaesthetists are likely to have major input into the care of the cancer patient. This input may start with the preoperative assessment, but often extends to the intensive care unit and the management of both acute and chronic disease, or procedural related pain. This book is comprised of five main sections dealing with cancer, anaesthesia for cancer surgery, intensive care, pain management and supportive and palliative care. The chapters are authored by acknowledged specialists in their field of cancer patient management. The anaesthesia section discusses not just major surgery but includes the specific and subtle differences that exist in the diverse types of specialist cancer surgery. The pain section deals with the current status of several specific cancer pain problems with contemporary evidence and recent developments in management. This book also introduces novel ways of looking at conventional treatments such as the genetic aspects of opioid use. For a complete understanding of the cancer patient, other aspects of care are also considered, including psychological care and complementary medicines.

Neuroeconomics

Author: Paul W. Glimcher

Publisher: Academic Press

Published: 2013-08-13

Total Pages: 606

ISBN-13: 0123914698

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In the years since it first published, Neuroeconomics: Decision Making and the Brain has become the standard reference and textbook in the burgeoning field of neuroeconomics. The second edition, a nearly complete revision of this landmark book, will set a new standard. This new edition features five sections designed to serve as both classroom-friendly introductions to each of the major subareas in neuroeconomics, and as advanced synopses of all that has been accomplished in the last two decades in this rapidly expanding academic discipline. The first of these sections provides useful introductions to the disciplines of microeconomics, the psychology of judgment and decision, computational neuroscience, and anthropology for scholars and students seeking interdisciplinary breadth. The second section provides an overview of how human and animal preferences are represented in the mammalian nervous systems. Chapters on risk, time preferences, social preferences, emotion, pharmacology, and common neural currencies—each written by leading experts—lay out the foundations of neuroeconomic thought. The third section contains both overview and in-depth chapters on the fundamentals of reinforcement learning, value learning, and value representation. The fourth section, “The Neural Mechanisms for Choice, integrates what is known about the decision-making architecture into state-of-the-art models of how we make choices. The final section embeds these mechanisms in a larger social context, showing how these mechanisms function during social decision-making in both humans and animals. The book provides a historically rich exposition in each of its chapters and emphasizes both the accomplishments and the controversies in the field. A clear explanatory style and a single expository voice characterize all chapters, making core issues in economics, psychology, and neuroscience accessible to scholars from all disciplines. The volume is essential reading for anyone interested in neuroeconomics in particular or decision making in general. Editors and contributing authors are among the acknowledged experts and founders in the field, making this the authoritative reference for neuroeconomics Suitable as an advanced undergraduate or graduate textbook as well as a thorough reference for active researchers Introductory chapters on economics, psychology, neuroscience, and anthropology provide students and scholars from any discipline with the keys to understanding this interdisciplinary field Detailed chapters on subjects that include reinforcement learning, risk, inter-temporal choice, drift-diffusion models, game theory, and prospect theory make this an invaluable reference Published in association with the Society for Neuroeconomics—www.neuroeconomics.org Full-color presentation throughout with numerous carefully selected illustrations to highlight key concepts

Pain

Author: Margo McCaffery

Publisher:

Published: 1999

Total Pages: 824

ISBN-13:

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Pain: Clinical Manual advocates an interdiciplinary approach to the care of patients with often under-treated pain. This book makes the application to scientific knowledge to the development of practical tools and guidelines for the care of patients in all clinical settings and all age groups. * Provides ready-to-use forms and recommendations for pain care committees to assist health care facilities to prepare for JCAHO inspections. * Includes two FREE pocket-size, laminated cards: equianalgesic charts to assist clinicians with dose calculations when changing routes of administration or analgesics, and dosing guides to commonly used adjuvants and nonopioids. * Includes FREE access to Mosby's PAIN WEBSITE. * The most clinically useful book ever published on pain, written by authorities who helped establish the pain management movement. * Includes 11 new chapters and five expanded and updated chapters to provide the most accurate, up-to-date, and comprehensive pain management information. * Includes icons to alert the reader to important, need-to-know information, such as pediatric content, patient examples, and reproducible material. * Features over 200 boxes and tables to help quickly locate key information and apply complex concepts at the bedside. * Presents a unique, multidisciplinary perspective. * Provides ready-to-use, practical, proven, and reproducible tools, pain assessment and documentation forms, and guides to analgesic use. * Contains patient information handouts on analgesics and nondrug methods of pain relief to educate the patient/family/caregiver about the patient's specific pain management. * Includes reproducible key policies, procedures, and protocols to assist the clinician in implementing patient focused interdisciplinary pain management. * Presents pharmacology content in four chapters - the three analgesic groups and an overview of how to combine them - to provide a readily understandable reference and practical resource. * Includes quick guides with illustrations of selected pain problems, such as pain related to sickle cell disease, peripheral neuropathy, and fibromyalgia. * Contains pain rating scales in over 20 languages to enhance patient/clinician communication in culturally diverse populations.

Guide to Research Techniques in Neuroscience

Author: Matt Carter

Publisher: Academic Press

Published: 2022-03-26

Total Pages: 416

ISBN-13: 0323915612

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Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

The Oxford Handbook of Negation

Author: Viviane Déprez

Publisher: Oxford University Press, USA

Published: 2020-03-31

Total Pages: 889

ISBN-13: 0198830521

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In this volume, international experts in negation provide a comprehensive overview of cross-linguistic and philosophical research in the field, as well as accounts of more recent results from experimental linguistics, psycholinguistics, and neuroscience. The volume adopts an interdisciplinary approach to a range of fundamental questions ranging from why negation displays so many distinct linguistic forms to how prosody and gesture participate in the interpretation of negative utterances. Following an introduction from the editors, the chapters are arranged in eight parts that explore, respectively, the fundamentals of negation; issues in syntax; the syntax-semantics interface; semantics and pragmatics; negative dependencies; synchronic and diachronic variation; the emergence and acquisition of negation; and experimental investigations of negation. The volume will be an essential reference for students and researchers across a wide range of disciplines, and will facilitate further interdisciplinary work in the field.

The Reproduction of Mothering

Author: Nancy Chodorow

Publisher: Univ of California Press

Published: 1999-11-02

Total Pages: 283

ISBN-13: 0520221559

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This text had a major impact on both feminists and psychoanalysts when it was first published, and it continues to shape the thinking of analysts and feminists today.

The Biology of Desire

Author: Marc Lewis

Publisher: PublicAffairs

Published: 2015-07-14

Total Pages: 256

ISBN-13: 1610394380

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Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the "disease model" of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it's supposed to do-seek pleasure and relief-in a world that's not cooperating. As a result, most treatment based on the disease model fails. Lewis shows how treatment can be retooled to achieve lasting recovery. This is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.