Challenges to Tackling Antimicrobial Resistance

Challenges to Tackling Antimicrobial Resistance PDF

Author: Michael Anderson

Publisher: Cambridge University Press

Published: 2020-04-23

Total Pages: 273

ISBN-13: 1108799450

DOWNLOAD EBOOK →

An accessible overview of the challenges in tackling AMR, and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses PDF

Author: OECD

Publisher: OECD Publishing

Published: 2020-04-01

Total Pages: 250

ISBN-13: 1108864120

DOWNLOAD EBOOK →

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

OECD Health Policy Studies Stemming the Superbug Tide

OECD Health Policy Studies Stemming the Superbug Tide PDF

Author: OECD.

Publisher: Org. for Economic Cooperation & Development

Published: 2019-01-21

Total Pages: 224

ISBN-13: 9789264307582

DOWNLOAD EBOOK →

Antimicrobial resistance (AMR) is a large and growing problem with the potential for enormous health and economic consequences, globally. As such, AMR has become a central issue at the top of the public health agenda of OECD countries and beyond. In this

Exploring the Frontiers of Innovation to Tackle Microbial Threats

Exploring the Frontiers of Innovation to Tackle Microbial Threats PDF

Author: Engineering National Academies of Sciences (and Medicine)

Publisher:

Published: 2020

Total Pages: 158

ISBN-13: 9780309675345

DOWNLOAD EBOOK →

On December 4-5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop.

The Resistance Phenomenon in Microbes and Infectious Disease Vectors

The Resistance Phenomenon in Microbes and Infectious Disease Vectors PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2003-03-26

Total Pages: 333

ISBN-13: 0309168309

DOWNLOAD EBOOK →

The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.

Antimicrobial Resistance in Developing Countries

Antimicrobial Resistance in Developing Countries PDF

Author: Aníbal de J. Sosa

Publisher: Springer Science & Business Media

Published: 2009-10-08

Total Pages: 553

ISBN-13: 0387893709

DOWNLOAD EBOOK →

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Ethics and Drug Resistance: Collective Responsibility for Global Public Health

Ethics and Drug Resistance: Collective Responsibility for Global Public Health PDF

Author: Euzebiusz Jamrozik

Publisher: Springer

Published: 2021-08-21

Total Pages: 448

ISBN-13: 9783030278762

DOWNLOAD EBOOK →

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Antimicrobial Resistance

Antimicrobial Resistance PDF

Author: Sabu Thomas

Publisher: Springer

Published: 2020-07-24

Total Pages: 230

ISBN-13: 9789811536571

DOWNLOAD EBOOK →

Antimicrobial resistance is a major global public health problem. This book focuses on the clinical implications of multi-drug resistant pathogens; tracking AMR and its evolutionary significance; antifungal resistance; and current and alternative treatment strategies for AMR, including antivirulent, antibiofilm and antimicrobial resistance breakers, repurposing of drugs, and probiotic therapy. Advances in antimicrobial stewardship, antibiotic policies from a global perspective and their impacts are also discussed. The book also explores the use of omics approaches to gain insights into antibacterial resistance, and includes chapters on the potential benefits of a ‘One Health approach’ describing the environmental and zoonotic sources of resistant genes and their effects on the global resistance pool.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis PDF

Author: Marc Stadler

Publisher: Springer

Published: 2016-12-21

Total Pages: 496

ISBN-13: 3319492845

DOWNLOAD EBOOK →

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Improving Food Safety Through a One Health Approach

Improving Food Safety Through a One Health Approach PDF

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2012-09-10

Total Pages: 418

ISBN-13: 0309259363

DOWNLOAD EBOOK →

Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.