Cellular Mechanisms during Normal and Abnormal Craniofacial Development
Author: Poongodi Geetha-Loganathan
Publisher: Frontiers Media SA
Published: 2022-03-30
Total Pages: 319
ISBN-13: 2889747913
DOWNLOAD EBOOK →Author: Poongodi Geetha-Loganathan
Publisher: Frontiers Media SA
Published: 2022-03-30
Total Pages: 319
ISBN-13: 2889747913
DOWNLOAD EBOOK →Author: Murray Clyde Meikle
Publisher:
Published: 2002
Total Pages: 390
ISBN-13:
DOWNLOAD EBOOK →"Over the past twenty years craniofacial biology has been revolutionized by major developments in our understanding of the cellular, molecular and genetic mechanisms underlying embryonic development. Many of these advances have been based on animal models, most notably the fruitfly Drosophila, the chick and the mouse. Since these developmental processes have been highly conserved during evolution, this information is relevant not only to understanding normal human development but also to understanding how genetic mutations produce particular malformations or inherited diseases. This book incorporates these discoveries into traditional morphological description of craniofacial development, and in a form accessible to clinicians with an interest in the head and neck." --book cover.
Author: Rachel Segal Greenberg
Publisher:
Published: 2019
Total Pages:
ISBN-13:
DOWNLOAD EBOOK →Formation of craniofacial structures is a delicate developmental process that is disrupted in many disease states. These disease states can occur due to genetic anomalies within a developing embryo or environmental irregularities in utero during gestation. Frequently, craniofacial developmental disorders are caused by defects in a particular population of transient, migratory stem cells called neural crest cells. In my Dissertation research, I have endeavored to elucidate the molecular and cellular mechanisms underlying specific genetic disorders and exposure to specific teratogens, with a focus on the fascinating cell type that is the neural crest cell (NCC). To this end, I have studied craniofacial disorder Floating-Harbor Syndrome (FHS), which is caused by heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler that mediates incorporation of histone variant H2A.Z. I demonstrated that FHS-associated mutations result in loss of SRCAP nuclear localization, alter neural crest gene programs in human in vitro models and Xenopus laevis embryos, and cause craniofacial defects. These defects are mediated by one of two H2A.Z subtypes, H2A.Z.2, whose knockdown mimics and whose overexpression rescues the FHS phenotype. Selective rescue by H2A.Z.2 is conferred by one of the three amino acid differences that evolved between the H2A.Z subtypes, S38/T38. I further showed that H2A.Z.2 preferentially occupies AT-rich enhancers, while H2A.Z.1 broadly binds regulatory regions, with the highest enrichment at promoters. Genes associated with H2A.Z.2-enriched enhancers are sensitized to heterozygous SRCAP truncations. Altogether, these results illuminate the mechanism underlying a human syndrome and uncover selective functions of H2A.Z subtypes during development. In addition, I have studied how Zika virus (ZIKV) infection during pregnancy, which is linked to microcephaly, can affect neural crest cell in vitro. In addition to giving rise to most cranial bones, NCCs exert paracrine effects on the developing brain. I reported that NCCs are productively infected by ZIKV, but not by the related dengue virus. These ZIKV-infected NCCs undergo limited apoptosis but secrete cytokines that promote death and drive aberrant differentiation of neural progenitor cultures. Addition of two such cytokines, LIF or VEGF, at levels comparable to those secreted by ZIKV-infected NCCs is sufficient to recapitulate premature neuronal differentiation and apoptotic death of neural progenitors. My results suggest that NCC infection by ZIKV may contribute to associated embryopathies through signaling crosstalk between developing face and brain structures.
Author: Paul Trainor
Publisher: Academic Press
Published: 2013-11-23
Total Pages: 488
ISBN-13: 0124045863
DOWNLOAD EBOOK →Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association Provides timely, comprehensive synthesis of the current knowledge of neural crest cells Covers the evolution and development of neural crest cells Includes content on applications for tissue engineering, repair and regeneration
Author: Agnes Bloch-Zupan
Publisher: Elsevier
Published: 2012-03-21
Total Pages: 265
ISBN-13: 0124160387
DOWNLOAD EBOOK →Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format
Author: National Research Council
Publisher: National Academies Press
Published: 2000-12-21
Total Pages: 348
ISBN-13: 0309070864
DOWNLOAD EBOOK →Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Erika Kuchler
Publisher: Frontiers Media SA
Published: 2021-10-13
Total Pages: 191
ISBN-13: 2889714713
DOWNLOAD EBOOK →Author: Michel Stricker
Publisher:
Published: 1990
Total Pages: 616
ISBN-13:
DOWNLOAD EBOOK →This work covers craniofacial malformations and growth, and their treatment, surgery and classification. Written for practising plastic surgeons and maxillofacial surgeons, it should also be of interest to oral and ENT surgeons and orthodontists.
Author: Douglas W. DeSimone
Publisher: Springer Science & Business Media
Published: 2013-03-15
Total Pages: 260
ISBN-13: 3642359353
DOWNLOAD EBOOK →Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.