Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease

Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease PDF

Author: A.M. Municio

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 255

ISBN-13: 1461518792

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It is the great glory as it is also the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute. Peter Medawar, "The Threat and the Glory" An international symposium on "Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease" was held at EI Escorial (Spain) from July 5-9, 1993 as a summer course of the Complutense University in Madrid. The lectures were delivered by renowned scientists from Europe, America, and Asia and attended by a large number of young scientists and graduate students from many countries. During evolution multicellular organisms have developed the most sophisticated and heterogeneous signals to maintain in harmony their multiple functions. The latest and most controversial aspects and developments in signal transduction were the main focus of this course. The communication among participants was extremely fluid, alive, and warm. This allowed the understanding of the key steps in cellular communication, from their original and historical sources to the main present hypothesis in the borderline of the latest scientific discoveries in this field. Without any doubt, the special atmosphere of the place, the monuments and the old granite stones, the "patio" with the fountain and the rose garden were responsible for the cordial meeting. This book comprises the manuscripts of the participants and we hope it will contribute to our knowledge of cellular signal transduction and be of value to a wider scientific community.

Introduction to Cellular Signal Transduction

Introduction to Cellular Signal Transduction PDF

Author: Ari Sitaramayya

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 313

ISBN-13: 1461219906

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Our understanding of biological communication has grown significantly during the past decade. The advances in knowledge about the chemical nature of signals and their corresponding reception by specialized cells have led to identification, characterization, purification, cloning, and expression of specific receptor molecules. While the earlier literature emphasized com partmentalized treatment of informational molecules and their interaction with receptors, the progress in the recent past has allowed cross-fertilization in the examination of the of actions and mechanisms of steroid and protein hormones and other messengers. Investigators now have an increased ap preciation of the multiple effects of specific hormones and of the diverse responses by receptor proteins to closely related ligands. The task of compil ing this enormous literature into a focused treatise was undertaken with the launching of the series Hormones in Health and Disease. This latest volume, An Introduction to Cellular Signal Transduction, complements the previous monographs in the series and brings to the fore recent developments in the field of biochemical communication. This volume combines discussions on the basic tenets of the signal transduction process and its relevance to health and disease. While various chapters provide exhaustive dissection of specific topics for researchers in the field, the book is also an excellent vehicle for introducing students and new investigators to the subject. The contributors of the chapters are active and accomplished scientists brought together on a common platform by the editor, Dr.

Signal Transduction and Human Disease

Signal Transduction and Human Disease PDF

Author: Toren Finkel

Publisher: John Wiley & Sons

Published: 2003-07-18

Total Pages: 490

ISBN-13: 0471448370

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This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Cellular Signal Processing

Cellular Signal Processing PDF

Author: Friedrich Marks

Publisher: Garland Science

Published: 2017-05-17

Total Pages: 982

ISBN-13: 1351677217

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Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Signal Transduction

Signal Transduction PDF

Author: Bastien D. Gomperts

Publisher: Gulf Professional Publishing

Published: 2002-03-18

Total Pages: 450

ISBN-13: 9780122896316

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Prologue: Signal transduction, origins and personalities. -- First messengers. -- Receptors. -- GTP-binding proteins and signal transduction. -- Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase. -- The regulation of visual transduction. -- Calcium and signal transduction. -- Calcium signalling. -- Phosphorylation and dephosphorylation:protein kinases A and C. -- Growth Factors :setting the framework. -- Signalling pathways operated by receptor protein tyrosine kinases. -- Signalling pathways operated by non-receptor protein tyrosine kinases. -- Phosphoinositide 3-kinases. -- Signal transduction to and from adhesion molecules. -- Adhesion molecules and trafficking of leukocytes. -- Signalling through receptor bound protein serine-threonine kinases. -- Protein dephosphorylation and protein phosphorylation. -- Protein domains and signal transduction.

Signal Transduction: Pathways, Mechanisms and Diseases

Signal Transduction: Pathways, Mechanisms and Diseases PDF

Author: Ari Sitaramayya

Publisher: Springer Science & Business Media

Published: 2009-12-02

Total Pages: 429

ISBN-13: 3642021123

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Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Trends in Signal Transduction Research

Trends in Signal Transduction Research PDF

Author: Jennifer N. Meyers

Publisher: Nova Publishers

Published: 2007

Total Pages: 270

ISBN-13: 9781600213755

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Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease PDF

Author: Ashok K. Srivastava

Publisher: Springer Science & Business Media

Published: 2008-10-17

Total Pages: 426

ISBN-13: 0387095519

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Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.