Cell-Extracellular Matrix Interactions in Cancer

Cell-Extracellular Matrix Interactions in Cancer PDF

Author: Roy Zent

Publisher: Springer Science & Business Media

Published: 2010-01-23

Total Pages: 316

ISBN-13: 1441908145

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Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Cell-Extracellular Matrix Interactions in Cancer

Cell-Extracellular Matrix Interactions in Cancer PDF

Author: Roy Zent

Publisher: Springer Science & Business Media

Published: 2010-10-22

Total Pages: 316

ISBN-13: 1441908153

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Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Extracellular Matrix: Pathobiology and Signaling

Extracellular Matrix: Pathobiology and Signaling PDF

Author: Nikos Karamanos

Publisher: Walter de Gruyter

Published: 2012-08-31

Total Pages: 940

ISBN-13: 3110258773

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Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Extracellular Matrix in Tumor Biology

Extracellular Matrix in Tumor Biology PDF

Author: Rolf A. Brekken

Publisher: Springer

Published: 2017-08-04

Total Pages: 115

ISBN-13: 3319609076

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This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Second Harmonic Generation Imaging

Second Harmonic Generation Imaging PDF

Author: Francesco S. Pavone

Publisher: Taylor & Francis

Published: 2016-04-19

Total Pages: 465

ISBN-13: 1439849153

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Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview PDF

Author: Robert Mecham

Publisher: Springer Science & Business Media

Published: 2011-02-16

Total Pages: 429

ISBN-13: 3642165559

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Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer

Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer PDF

Author:

Publisher:

Published: 1997

Total Pages: 0

ISBN-13:

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Differential display was exploited to analyze expression patterns of premalignant (S2) and tumor (T4) cells, two sublines of a unique human breast cancer progression HMT3522 series, to identify candidate genes participating in the final-stage tumorigenic conversion in breast cancer. Message levels of a novel gene AZ-i was significantly lower in T4 than in S2 cells cultured either on plastic or in 3-D matrix system. Az-i was abundantly present in nonmalignant counterpart S 1 and human breast luminal epithelial cells. In contrast, expression of this gene was drastically repressed in ten human breast epithelial cancer lines. Modulation of Az-i gene expression by phenotypic alteration of tumor cells was examined in a reversion system described recently in our laboratory. Briefly, when T4 cells were cultured in the presence of inhibitory % 1 -integrin antibody in a 3-D system, they reverted morphologically to S 1-like cells. They formed acini while re-assembled a basement membrane, reorganized cytoskeleton network, suppressed cyclin Di and were growth arrested. Interestingly, AZ-i gene was up-regulated in the reverted T4 cells to a level reminiscent of that seen in the S I cells. Based on the sequence homology with coiled-coil domain of several structural proteins, i.e., myosin heavy chain and desmoplakin I and II, Az-i may play a role in organization of cytoskeletal architecture.

Extracellular Matrix

Extracellular Matrix PDF

Author: Susan Hawkes

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 437

ISBN-13: 0323150411

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Extracellular Matrix contains the proceedings of the symposium ""The Extracellular Matrix,"" sponsored by the Michigan Molecular Institute and held in Midland, Michigan, on June 28-July 2, 1982. The papers explore the role played by the extracellular matrix (ECM) in the physiology of a cell, particularly in the regulation of cellular phenotypes, differentiation, and proliferation. The progress made in isolating and defining the chemistry and functional interactions of the ECM components is discussed, along with the biology of the ECM. This book is comprised of 52 chapters and begins with an introduction to the ECM, with emphasis on the question of whether the malignant process can be defined in a cell culture model, and in particular, whether the pericellular matrix is characteristically altered in cancer. The discussion then turns to the structure of the heparan sulfate proteoglycans and the molecular mechanisms responsible for the association of these molecules with the surfaces of cultured cells. Subsequent chapters focus on the chemistry of ECM components such as collagen, glycosaminoglycans, and adhesive glycoproteins, along with their functional interactions, biosynthesis, turnover, and degradation. The final section is devoted to the diseased states of ECM. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

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