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Cardiovascular Benefits of Omega-3 Polyunsaturated Fatty Acids

Author: B. Maisch

Publisher: IOS Press

Published: 2007-01-18

Total Pages: 196

ISBN-13: 1607502224

During the last decades progress has been made in the treatment of patients who survived myocardial infarction. Nevertheless, patients who survive an acute myocardial infarction are at high risk, with life expectancy half that of their peers who have not experienced similar events, and with increased risk for subsequent cardiovascular events and death. The risk of sudden death increases with severity of systolic dysfunction after myocardial infarction. In recent years, it has become clear that in addition to risk factors such as overweight, lack of exercise, smoking, hypertension and hypercholesterolemia, psychosocial factors play a key role for prognosis in patients with myocardial infarction. Therefore, there is high medical need for drugs which lower the incidence of sudden death and have an effect on other risk factors such as depression. OMACOR®, a pharmaceutical preparation of highly purified and concentrated Ω-3 polyunsaturated acids, may present such a drug. It lowers the incidence of sudden death in patients with myocardial infarction and decreases depression. This publication focuses on the effect of Ω-3 polyunsaturated fatty acids on different risk factors in patients with cardiovascular disease. In addition, aspects of prevention of cardiovascular disease, risk factors and pharmacokinetics of Ω-3 fatty acids ethyl esters are considered.

The Effects of Omega-3 Polyunsaturated Fatty Acids on Cardiac Rhythm: Antiarrhythmic, Proarrhythmic, Both or Neither?

Author: George E. Billman

Publisher: Frontiers E-books

Published:

Total Pages: 142

ISBN-13: 2889190889

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The cardiovascular benefits of dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) have been actively investigated for nearly 40 years. Beginning with the pioneering studies of Bang and Dyerberg, epidemiological data provide strong evidence for an inverse relationship between fatty fish consumption and cardiac mortality. In contrast to these observational studies, interventional studies using n-3 PUFAs for the secondary prevention of adverse cardiovascular events in patients with heart disease have yielded conflicting results; some studies have reported reduced sudden cardiac death or mortality, while other more recent studies have reported either no effect or an increase in adverse cardiac events. Nevertheless, the American Heart Association and the American College of Cardiology continue to recommend fish oils for the secondary prevention of coronary artery disease. Based in part upon these recommendations, consumer demand for n-3 PUFA products (both nutritional supplements and foods enriched with these lipids) has exploded. In the United States alone, it has been estimated that in 2004, 5-10% of the adult U.S. population were taking a fish oil supplement, with annual sales growth of 40%. In fact, the sales of these products are projected to exceed 7 billion dollars by the end of 2011 (www.marketresearch.com, product reports). Despite the extensive marketing of fish oil products, a scientific consensus on the effects of n-3 PUFA on cardiac rhythm has yet to be reached. It is the purpose of this Research Topic to stimulate a discussion on the putative benefits of n-3 PUFAs on cardiac rhythm. Authors are invited to submit clinical, translational, or experimental research articles, reviews, and hypotheses that address the actions of n-3 PUFA (positive, negative, or neutral) on cardiac rhythm and cardiac electrophysiology. Studies that evaluate the effects of n-3 PUFA on myocyte electrical properties, atrial fibrillation, ventricular fibrillation, and heart rate variability are particularly welcome.

Omega Fatty Acids in Brain and Neurological Health

Author: Ronald Ross Watson

Publisher: Academic Press

Published: 2019-06-12

Total Pages: 518

ISBN-13: 0128152397

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Research has clearly established a link between omega fatty acids and general health, particularly cardiovascular health. Omega Fatty Acids in Brain and Neurological Health, Second Edition, illustrates the importance of omega-3 fatty acids in longevity, cognitive impairment and structure and function of the brain's neurons and also the adverse effects of omega-6 fatty acids on neurological function. This book encompasses some of the most recent research on the links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep and neurodegenerative diseases. This completely updated second edition focuses on the counterbalancing dietary and tissue omega-6 fatty acids as well as it studies the effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases. Provides a comprehensive introduction to omega-3 and omega-6 fatty acids in neurological health and directions for future research Features novel focus on the adverse effects of omega-6 fatty acids on neurological function and the counterbalancing of dietary and tissue omega-6 Illustrates the importance of omega-3 fatty acids in longevity and cognitive impairment Features new chapters on early effects in pregnancy and early infancy, animal model studies and autoimmune neurological diseases Discusses links between omega fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis, including the role of omega-3 fatty acid supplements

Nutrition and Traumatic Brain Injury

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-07-01

Total Pages: 444

ISBN-13: 0309210089

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Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

Effects of omega-3 fatty acids on cardiovascular disease

Author:

Publisher:

Published: 2004

Total Pages: 8

ISBN-13:

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Fatty Acids and Lipids

Author: International Society for the Study of Fatty Acids and Lipids. Congress

Publisher: Karger Medical and Scientific Publishers

Published: 2001-01-01

Total Pages: 271

ISBN-13: 3805571828

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The publication at hand gives an outline of recent advances in both of these topics, including a general discussion on fatty acid nutrition amd metabolism. Moreover, issues such as vascular functions, inflammation, bone metabolism, cancer, obesity and lipoprotein metabolism are dealt with in this context. Finally, the book also contains new findings on bioactive lipids such as anandamide and related compounds, as well as on conjugated linoleic acid. Scientists interested in nutrition, cardiovascular disease, behavior and psychiatry as well as fatty acid metabolism and lipids in general will find this publication a most welcome source of information.

Nutritional Health

Author: Norman J. Temple

Publisher: Springer Science & Business Media

Published: 2012-07-27

Total Pages: 570

ISBN-13: 1617798940

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Now going into its third much-expanded edition, the highly praised Nutritional Health: Strategies for Disease Prevention has been brought fully up to date to include all the new thinking and discoveries that have the greatest capacity to improve human health and nutritional advancement. About half the new edition will be revised and updated from the second edition while the other half will consist of major revisions of previous chapters or new subjects. Like the two previous editions the book will consist of general reviews on various topics in nutrition, especially those of much current interest. The authors provide extensive, in-depth chapters covering the most important aspects of the complex interactions between diet, its nutrient components, and their impacts on disease states, and on those health conditions that increase the risk of chronic dieases. Up to date and comprehensive, Nutritional Health: Strategies for Disease Prevention, Third Edition offers physicians, dietitians, and nutritionists a practical, data-driven, integrated resource to help evaluate the critical role of nutrition.

OMEGA-3

Author: Sean J. Moore

Publisher:

Published: 2017

Total Pages: 169

ISBN-13: 9781536118391

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Compelling data shows cardiovascular beneficial effects in consuming fatty acids highly present in fish, such as omega 3, docosahexanoic acid (DHA 22:6 omega 3), and eicosapentanoic acid (EPA 20:5 omega 3). These fatty acids regulate cell membrane physicochemical properties (i.e., fluidity, organization and permeability) that affect signaling pathways, with probable antioxidant and anti-inflammatory effects on cardiac and vascular tissue. Interest in the physiological and pharmacological effects of omega-3 polyunsaturated fatty acids (PUFA), in particular those of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), has increased significantly in recent years. Omega-3 PUFA, which are recognized as nutraceuticals, have been demonstrated to have clinical benefits for the prevention of and / or treatment of certain pathological conditions. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are increasingly being used to prevent cardiovascular disease. Omega-3 PUFAs may prevent atherosclerosis and cardiovascular disease development by targeting arterial stiffness and endothelial dysfunction administration.

Health Effects of Polyunsaturated Fatty Acids in Seafoods

Author: Artemis P Simopoulos

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 486

ISBN-13: 032313811X

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Health Effects of the Polyunsaturated Fatty Acids in Seafoods emerged from the 1985 Proceedings of a Conference on Health Effects of Polyunsaturated Fatty Acids in Seafoods held in Washington, D.C., spearheaded by the National Fisheries Institutes of Health (NIH), the Department of Commerce (DOC), and the National Fisheries Institute (NFI). The conference aims to review the data about the health effects of polyunsaturated fatty acids in seafood; the impact of omega-3 fatty acids on eicosanoid formation, thrombosis, and inflammation; and the role of docosahexaenoic acid in membrane function and metabolism. It also encourages the researchers to study the possible origin of the health effects of seafood in the American diet. Composed of seven parts, the book begins by discussing the summary, conclusions, and recommendations the chairman of each working groups presented during the conference. It also explains the effects of fatty acids on lipoprotein and generation of products of the 5-Lipoxygenase pathway and the membrane functioning and metabolism. Moreover, it discusses the status of the fishery industries worldwide, the different classes of lipids that contain fatty acids, and recipes with seafood as the main ingredient. This book will be of great interest to the scientists such as basic researchers, clinical investigators, and epidemiologists, as well as to health personnel and consumers.

Omega-6/omega-3 Essential Fatty Acid Ratio

Author: Artemis P. Simopoulos

Publisher: Karger Medical and Scientific Publishers

Published: 2003-01-01

Total Pages: 188

ISBN-13: 3805576404

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Studies on the evolutionary aspects of diet and molecular studies included in this volume indicate that human beings evolved on a diet that was balanced in the essential fatty acids (EFA). In fact, the ratio of omega-6/omega-3 EFA was 1/1 whereas present day diets in both developed and developing countries have a much higher ratio, between 5/1 and 50/1. Additional studies show that a high ratio of omega-6/omega-3 EFA is detrimental to health and may lead to the development of chronic diseases. Improving the dietary ratio by decreasing the omega-6 fatty acids and increasing the omega-3 fatty acids is essential for brain function and for the management of cardiovascular disease, arthritis and cancer. A ratio of 4/1 or less leads to lower dosage and to the reduction of adverse effects of drugs. This volume should be of interest to a large and varied audience of researchers in academia, industry, and government; cardiologists, geneticists, immunologists, neuroscientists, and cancer specialists; as well as nutritionists, dietitians, food scientists, agriculturists, economists and regulators.