Brain Energy Metabolism

Brain Energy Metabolism PDF

Author: Johannes Hirrlinger

Publisher: Humana Press

Published: 2014-09-16

Total Pages: 0

ISBN-13: 9781493910588

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Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

Brain Energy Metabolism

Brain Energy Metabolism PDF

Author: Johannes Hirrlinger

Publisher: Humana

Published: 2016-09-17

Total Pages: 0

ISBN-13: 9781493944668

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Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.

The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration

The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration PDF

Author: Fei Yin

Publisher: Frontiers Media SA

Published: 2017-08-16

Total Pages: 161

ISBN-13: 2889452530

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Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.

Brain Glycogen Metabolism

Brain Glycogen Metabolism PDF

Author: Mauro DiNuzzo

Publisher: Springer Nature

Published: 2019-10-31

Total Pages: 443

ISBN-13: 3030274802

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This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.

Cellular Metabolism and Related Disorders

Cellular Metabolism and Related Disorders PDF

Author: Jesmine Khan

Publisher: BoD – Books on Demand

Published: 2020-07-15

Total Pages: 230

ISBN-13: 1838801812

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This book deals with a vital topic: metabolism in the cells of the body and various disorders due to its imbalance and/or diseases that disrupt the metabolism of the body. The objective of this book was to collect and compile up-to-date information from reputed researchers in their respective fields to disseminate the latest information about topics that have profound effects on the metabolic processes in the body including insulin resistance, diabetes mellitus, hypothyroidism, metabolic syndrome, glycogen storage disease, and the urea cycle disorder. In total, there are 12 chapters in this book in which the authors have shared their research findings and real-life experiences in managing their patients.

Brain Energy Metabolism

Brain Energy Metabolism PDF

Author: John Edmond

Publisher: S Karger Ag

Published: 1996-01-01

Total Pages: 230

ISBN-13: 9783805563901

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Authored by internationally recognized scientists, this special issue of Developmental Neuroscience presents selected papers from the Second International Meeting on Brain Energy Metabolism held at Blaubeuren, Germany, in 1995. It expands the research focus dealing with functional aspects of energy metabolism in neural tissue that was presented at the first meeting at Carcassonne in 1993. New evidence is presented on the complexity and importance of the continuous dynamic trafficking of key substances between astrocytes and neurons, all promoting significant roles for the astroglial cell population in the metabolic integrity of neural tissue. The latest studies shed new light on current issues of neural amino acid and carbohydrate metabolism. Papers deal with metabolic mechanisms for cellular responses to stress and damage from a variety of insults, and develop insights on the interrelationships and interdependence of the different neural cell populations. This up-to-date publication incorporates a wealth of knowledge and points to new directions in research which are of significance to a broad spectrum of developmental neuroscientists as well as to researchers in physiology, biochemistry and nutrition with an interest in brain energy metabolism.

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