Brain Aging: Neurodegeneration and Therapeutic Interventions

Brain Aging: Neurodegeneration and Therapeutic Interventions PDF

Author: Isla Pearson

Publisher:

Published: 2022-09-27

Total Pages: 0

ISBN-13: 9781639890859

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Aging causes changes in all the parts of the body including the brain. The size, vasculature and cognition of brain change with age. It causes changes at all levels, from molecules to morphology. Brain shrinks and incidence of stroke, dementia and white matter lesions increase with advancing age. There are changes in the levels of hormones and neurotransmitters. Regular exercise, low alcohol intake and a healthy diet are a few protective measures that reduce cardiovascular risk as well as aid the aging brain. The changes in the brain are not uniform in all regions. Another factor that affects the aging of brain and its cognitive performance is hormonal influence. Aging is one of the most important risk factors for neurodegenerative diseases such as Alzheimer's and Parkinson's disease. This book provides significant information of this discipline to help develop a good understanding of brain aging. The topics covered herein deal with the therapeutic interventions in brain aging. This book will prove to be immensely beneficial to students and researchers in this field.

Brain Aging and Therapeutic Interventions

Brain Aging and Therapeutic Interventions PDF

Author: Mahendra K. Thakur

Publisher: Springer Science & Business Media

Published: 2012-12-11

Total Pages: 300

ISBN-13: 9400752377

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This book brings together most up-to-date information on different aspects of brain aging and on the strategies for intervention and therapy of age-related brain disorders. It includes 18 chapters by leading researchers, and each chapter is a comprehensive and critical review of the topic in question, discusses the current scenario and focuses on future perspectives. The target readership is the undergraduate and graduate students in the universities, in medical and nursing colleges, along with the post-graduate researchers and practicing clinicians who would like to know about the latest developments in the field of neurodegenerative disorders and their therapeutic interventions. This book will be of much interest to pharmaceutical, nutrition and healthcare industry for an easy access to accurate and reliable information in the field of aging research and intervention.

Handbook of the Neuroscience of Aging

Handbook of the Neuroscience of Aging PDF

Author: Patrick R. Hof

Publisher: Academic Press

Published: 2010-05-22

Total Pages: 712

ISBN-13: 0080954057

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A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers Heavily illustrated with over 100 color figures

Nutritional Interventions on Age-Related Neurodegenerative Diseases

Nutritional Interventions on Age-Related Neurodegenerative Diseases PDF

Author: Tiantian Zhang

Publisher: Frontiers Media SA

Published: 2023-10-16

Total Pages: 164

ISBN-13: 2832528287

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As the population grows older, strategies that can promote healthy aging and offset the development of age-related neurodegenerative diseases are becoming increasingly relevant. Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. The brain has a high demand for nutrients and nutritional imbalances dampen the structural and functional integrity of the brain critically impacting our cognitive capacities. Indeed, several lines of evidence suggest that nutritional strategies can reduce the risk of age-related neurodegenerative diseases and exhibit potential beneficial effects in delaying the onset of brain diseases and slowing down the progression of some conditions. Some studies have shown that nutritional interventions improve cognitive function in patients with AD. However, the research linking the role of nutritional interventions with age-related neurodegenerative diseases is still in the initial stage and has made little progress. It is still currently unclear if dietary ingredients can impact and modulate brain aging and neurodegeneration, especially the molecular mechanism of nutritional interventions promoting brain health are not yet clear. The development of effective nutritional interventions for promoting healthy aging is becoming an emerging and challenging area.

Neurodegenerative Diseases

Neurodegenerative Diseases PDF

Author: Nagehan Ersoy Tunalı

Publisher: BoD – Books on Demand

Published: 2021-01-20

Total Pages: 180

ISBN-13: 1838801499

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Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases PDF

Author: Michael S. Wolfe

Publisher: Academic Press

Published: 2018-03-29

Total Pages: 560

ISBN-13: 0128113057

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The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases PDF

Author:

Publisher: Academic Press

Published: 2020-08-25

Total Pages: 322

ISBN-13: 012823122X

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Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases

The Aging Mind

The Aging Mind PDF

Author: National Research Council

Publisher: National Academies Press

Published: 2000-04-18

Total Pages: 285

ISBN-13: 0309172195

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Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.