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Biostatistics for Human Genetic Epidemiology

Author: Bertram K. C. Chan

Publisher: Springer

Published: 2018-10-24

Total Pages: 355

ISBN-13: 331993791X

The book illustrates how biostatistics may numerically summarize human genetic epidemiology using R, and may be used successfully to solve problems in quantitative Genetic Epidemiology Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications. Biostatistics for Human Genetic Epidemiology is an ideal reference for professionals and students in Medicine (particularly in Preventive Medicine and Public Health Medical Practices), as well as in Genetics, Epidemiology, and Biostatistics.

Statistical Methods in Genetic Epidemiology

Author: Duncan C. Thomas

Publisher: Oxford University Press

Published: 2004-01-29

Total Pages: 458

ISBN-13: 0199748055

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This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

Biostatistics for Human Genetic Epidemiology

Author: Bertram Kim-Cheong Chan

Publisher:

Published: 2018

Total Pages: 355

ISBN-13: 9783319937922

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"Biostatistics for Human Genetic Epidemiology provides statistical methodologies and R recipes for human genetic epidemiologic problems. It begins by introducing all the necessary probabilistic and statistical foundations, before moving on to topics related human genetic epidemiology, with R codes illustrations for various examples. This clear and concise book covers human genetic epidemiology, using R in data analysis, including multivariate data analysis. It examines probabilistic and statistical theories for modeling human genetic epidemiology – leading the readers through an effective epidemiologic model, from simple to advanced levels. Classical mathematical, probabilistic, and statistical theory are thoroughly discussed and presented. This book also presents R as a calculator and using R in data analysis. Additionally, it covers Advanced Human Genetic Data Concepts, the Study of Human Genetic Variation, Manhattan Plots, as well as the Procedures for Multiple Comparison. Numerous Worked Examples are provided for illustrations of concepts and real-life applications"--Publisher's description.

Biostatistical Genetics and Genetic Epidemiology

Author: Robert C. Elston

Publisher: John Wiley & Sons

Published: 2002-04-22

Total Pages: 860

ISBN-13: 9780471486312

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"Human Genetics and Genetic Epidemiology" ist der 3. Band aus der sehr erfolgreichen Reihe 'Wiley Biostatistics Reference Series', die auf Artikeln der "Encyclopedia of Biostatistics" basiert. Dieser Band gibt einen topaktuellen und umfassenden Überblick über ein Forschungsgebiet, das insbesondere im Zuge des Human-Genomprojekts eine regelrechte Explosion an Forschungsaktivitäten erlebt hat. Enthalten sind komplett aktualisierte Artikel aus der "Encyclopedia of Biostatistics" sowie über 25% neue Artikel. Mit einem komplexen System an Querverweisen, die das Auffinden der gewünschten Information erheblich erleichtern. Eine interessante Lektüre für Genetiker, Epidemiologen, Biostatistiker und Forscher in diesen Bereichen.

Basic Biostatistics for Geneticists and Epidemiologists

Author: Robert C. Elston

Publisher: John Wiley & Sons

Published: 2008-11-20

Total Pages: 384

ISBN-13: 0470024917

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Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares. Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research. Is illustrated throughout with simple examples to clarify the statistical methodology. Explains Bayes’ theorem pictorially. Features exercises, with answers to alternate questions, enabling use as a course text. Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.

Biostatistics and Epidemiology

Author: Sylvia Wassertheil-Smoller

Publisher: Springer Science & Business Media

Published: 2006-05-10

Total Pages: 249

ISBN-13: 0387218297

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For the new edition of Biostatistics and Epidemiology, Dr. Wassertheil-Smoller has included several new chapters (genetic statistics, molecular epidemiology, scientific integrity and research ethics) and a new appendix on the basic concepts of genetics and a glossary of genetic terminology. She has also expanded the coverage of multi-center trials (an important aspect of implementation of the standards of evidence-based medicine), controversies in screening for prostate, colon, breast, and other cancers.

Fundamentals of Genetic Epidemiology

Author: Muin J. Khoury

Publisher: Monographs in Epidemiology and

Published: 1993

Total Pages: 394

ISBN-13: 0195052889

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This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.

An Introduction to Genetic Epidemiology

Author: Palmer, Lyle J.

Publisher: Policy Press

Published: 2011-05-31

Total Pages: 240

ISBN-13: 1861348975

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This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.

The Fundamentals of Modern Statistical Genetics

Author: Nan M. Laird

Publisher: Springer Science & Business Media

Published: 2010-12-13

Total Pages: 226

ISBN-13: 1441973389

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This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.

Biostatistics and Epidemiology

Author: Sylvia Wassertheil-Smoller

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 132

ISBN-13: 1475738870

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Biostatistics and Epidemiology/A Primer for Health Professionals offers practical guidelines and gives a concise framework for research and interpretation in the field. In addition to major sections covering statistics and epidemiology, the book includes a comprehensive exploration of scientific methodology, probability, and the clinical trial. The principles and methods described in this book are basic and apply to all medical subspecialties, psychology and education. The primer will be especially useful to public health officials and students looking for an understandable treatment of the subject.