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Biomaterials for MEMS

Author: Mu Chiao

Publisher: Pan Stanford Publishing

Published: 2011

Total Pages: 291

ISBN-13: 9814241466

This book serves as a guide for practicing engineers, researchers and students interested in MEMS devices and biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials. The book highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas, including the fabrication of devices using biomaterials, biocompatible coatings and issues, thin-film biomaterials and MEMS for tissue engineering, and applications involving MEMS and biomaterials.

Mems for Biomedical Applications

Author: Shekhar Bhansali

Publisher: Elsevier

Published: 2012-07-18

Total Pages: 511

ISBN-13: 0857096273

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The application of Micro Electro Mechanical Systems (MEMS) in the biomedical field is leading to a new generation of medical devices. MEMS for biomedical applications reviews the wealth of recent research on fabrication technologies and applications of this exciting technology.The book is divided into four parts: Part one introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms. Part two describes applications of MEMS for biomedical sensing and diagnostic applications. MEMS for in vivo sensing and electrical impedance spectroscopy are investigated, along with ultrasonic transducers, and lab-on-chip devices. MEMS for tissue engineering and clinical applications are the focus of part three, which considers cell culture and tissue scaffolding devices, BioMEMS for drug delivery and minimally invasive medical procedures. Finally, part four reviews emerging biomedical applications of MEMS, from implantable neuroprobes and ocular implants to cellular microinjection and hybrid MEMS.With its distinguished editors and international team of expert contributors, MEMS for biomedical applications provides an authoritative review for scientists and manufacturers involved in the design and development of medical devices as well as clinicians using this important technology. Reviews the wealth of recent research on fabrication technologies and applications of Micro Electro Mechanical Systems (MEMS) in the biomedical field Introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms Considers MEMS for biomedical sensing and diagnostic applications, along with MEMS for in vivo sensing and electrical impedance spectroscopy

Biomaterials for MEMS

Author: Mu Chiao

Publisher: CRC Press

Published: 2011-03-31

Total Pages: 292

ISBN-13: 9814241474

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This book serves as a guide for practicing engineers, researchers, and students interested in MEMS devices that use biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials.Biomaterials for MEMS highlights importan

Biomaterials Science

Author: Yitzhak Rosen

Publisher: CRC Press

Published: 2012-06-06

Total Pages: 328

ISBN-13: 1439804044

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"This book is essential when designing, developing and studying biomedical materials.... provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. ... This well presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering. ...[presents an] Interesting and innovative review from a patient focus perspective—the book emphasizes the importance of the patients, which is not often covered in other biomedical material’s books." —Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England Going far beyond the coverage in most standard books on the subject, Biomaterials Science: An Integrated Clinical and Engineering Approach offers a solid overview of the use of biomaterials in medical devices, drug delivery, and tissue engineering. Combining discussion of materials science and engineering perspectives with clinical aspects, this book emphasizes integration of clinical and engineering approaches. In particular, it explores various applications of biomaterials in fields including tissue engineering, neurosurgery, hemocompatibility, BioMEMS, nanoparticle-based drug delivery, dental implants, and obstetrics/gynecology. The book engages those engineers and physicians who are applying biomaterials at various levels to: Increase the rate of successful deployment of biomaterials in humans Lower the side-effects of such a deployment in humans Accumulate knowledge and experience for improving current methodologies Incorporate information and understanding relevant to future challenges, such as permanent artificial organ transplants Using a variety of contributors from both the clinical and engineering sides of the fields mentioned above, this book stands apart by emphasizing a need for the often lacking approach that integrates these two equally important aspects.

BioNanoFluidic MEMS

Author: Peter J. Hesketh

Publisher: Springer Science & Business Media

Published: 2007-11-15

Total Pages: 300

ISBN-13: 038746283X

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This book explains biosensor development fundamentals. It also initiates awareness in engineers and scientists who would like to develop and implement novel biosensors for agriculture, biomedicine, homeland security, environmental needs, and disease identification. In addition, the book introduces and lays the basic foundation for design, fabrication, testing, and implementation of next generation biosensors through hands-on learning.

MEMS-based Mechanical Characterization of Micrometer-sized Biomaterials

Author: Keekyoung Kim

Publisher:

Published: 2009

Total Pages: 302

ISBN-13:

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The mechanical properties of biomaterials play important roles in performing their specialized functions: synthesizing, storing, and transporting biomolecules; maintaining internal structures; and responding to external environments. Besides biological cells, there are also many other biomaterials that are highly deformable and have a diameter between 1mum and 100mum, comparable to that of most biological cells. For example, many polymeric microcapsules for drug delivery use are spherical particles of micrometers size. In order to characterize the mechanical properties of individual micrometer-sized biomaterials, the capability of capturing high-resolution and low-magnitude force feedback is required.Instead of compressing the microcapsule against the wall of the holding device using the force sensor, a force-feedback MEMS microgripper with the capability of directly compressing the microcapsule between two gripping arms has been used for characterizing both the elastic and viscoelastic properties of the microcapsules during micromanipulation. The single-chip microgripper integrates an electrothermal microactuator and two capacitive force sensors, one for contact detection (force resolution: 38.5nN) and the other for gripping force measurements (force resolution: 19.9nN). Through nanoNewton force measurements, closed-loop force control, and visual tracking, the system quantified the Young's modulus values and viscoelastic parameters of alginate microcapsules, demonstrating an easy-to-operate, accurate compression testing technique for characterizing soft, micrometer-sized biomaterials.The force sensors are capable of resolving forces up to 110muN with a resolution of 33.2nN along two independent axes. The monolithic force sensors were applied to characterizing the mechanical properties of soft hydrogel microparticles without assembling additional end-effectors. Protein-loaded alginate-chitosan microcapsules of ∼20mum in diameter were prepared by an emulsion-internal gelation-polyelectrolyte coating method. The microcapsules were immobilized by a PDMS holding device and compressed between the sensor probe and the holding device. Young's modulus values of individual microcapsules with 1%, 2%, and 3% chitosan coating were determined through the micro-scale compression testing in both distilled deionized (DDI) water and pH 7.4 phosphate buffered saline (PBS). The Young's modulus values were also correlated to protein release rates.This research focuses on the development of micro devices and experimental techniques for quantifying the mechanical properties of alginate-chitosan microcapsules. The micro devices include microelectromechanical systems (MEMS) capacitive force sensors and force-feedback microgrippers, capable of measuring sub-muN forces. Employing the MEMS devices, systems were constructed to perform the micro-scale compression testing of microcapsules.

Self-Powered and Soft Polymer MEMS/NEMS Devices

Author: Ajay Giri Prakash Kottapalli

Publisher: Springer

Published: 2019-02-28

Total Pages: 85

ISBN-13: 303005554X

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This book explores the fabrication of soft material and biomimetic MEMS sensors, presents a review of MEMS/NEMS energy harvesters and self-powered sensors, and focuses on the recent efforts in developing flexible and wearable piezoelectric nanogenerators. It also includes a critical analysis of various energy harvesting principles, such as electromagnetic, piezoelectric, electrostatic, triboelectric, and magnetostrictive. This multidisciplinary book is appropriate for students and professionals in the fields of material science, mechanical engineering, electrical engineering, and bioengineering.

Bio-MEMS

Author: Wanjun Wang

Publisher: CRC Press

Published: 2006-12-15

Total Pages: 490

ISBN-13: 1420018671

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This book considers both the unique characteristics of biological samples and the challenges of microscale engineering. Divided into three main sections, it first examines fabrication technologies using non-silicon processes, which are suitable for the materials more commonly used in medical/biological analyses. These include UV lithography, LIGA, nanoimprinting, and hot embossing. Attention then shifts to microfluidic components and sensing technologies for sample preparation, delivery, and analysis in microchannels and microchambers. The final section outlines various applications and systems at the leading edge of Bio-MEMS technology in a variety of areas such as drug delivery and proteomics.

Biomedical Microsystems

Author: Ellis Meng

Publisher: CRC Press

Published: 2011-06-22

Total Pages: 410

ISBN-13: 1420051237

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Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications. Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. A solutions manual is available for instructors who want to convert this reference to classroom use.

Fundamentals of BioMEMS and Medical Microdevices

Author: Steven Saliterman

Publisher: SPIE Press

Published: 2006

Total Pages: 644

ISBN-13: 9780819459770

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The world is on the threshold of a revolution that will change medicine and how patients are treated forever. Bringing together the creative talents of electrical, mechanical, optical and chemical engineers, materials specialists, clinical-laboratory scientists, and physicians, the science of biomedical microelectromechanical systems (bioMEMS) promises to deliver sensitive, selective, fast, low cost, less invasive, and more robust methods for diagnostics, individualized treatment, and novel drug delivery. This book is an introduction to this multidisciplinary technology and the current state of micromedical devices in use today. The first text of its kind dedicated to bioMEMS training. Fundamentals of BioMEMS and Medical Microdevices is Suitable for a single semester course for senior and graduate-level students, or as an introduction to others interested or already working in the field.