Biology in Time and Space: A Partial Differential Equation Modeling Approach

Biology in Time and Space: A Partial Differential Equation Modeling Approach PDF

Author: James P. Keener

Publisher: American Mathematical Soc.

Published: 2021-06-02

Total Pages: 308

ISBN-13: 1470454289

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How do biological objects communicate, make structures, make measurements and decisions, search for food, i.e., do all the things necessary for survival? Designed for an advanced undergraduate audience, this book uses mathematics to begin to tell that story. It builds on a background in multivariable calculus, ordinary differential equations, and basic stochastic processes and uses partial differential equations as the framework within which to explore these questions.

Methods of Small Parameter in Mathematical Biology

Methods of Small Parameter in Mathematical Biology PDF

Author: Jacek Banasiak

Publisher: Springer Science & Business

Published: 2014-04-19

Total Pages: 295

ISBN-13: 3319051407

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This monograph presents new tools for modeling multiscale biological processes. Natural processes are usually driven by mechanisms widely differing from each other in the time or space scale at which they operate and thus should be described by appropriate multiscale models. However, looking at all such scales simultaneously is often infeasible, costly, and provides information that is redundant for a particular application. Hence, there has been a growing interest in providing a more focused description of multiscale processes by aggregating variables in a way that is relevant to the purpose at hand and preserves the salient features of the dynamics. Many ad hoc methods have been devised, and the aim of this book is to present a systematic way of deriving the so-called limit equations for such aggregated variables and ensuring that the coefficients of these equations encapsulate the relevant information from the discarded levels of description. Since any approximation is only valid if an estimate of the incurred error is available, the tools the authors describe allow for proving that the solutions to the original multiscale family of equations converge to the solution of the limit equation if the relevant parameter converges to its critical value. The chapters are arranged according to the mathematical complexity of the analysis, from systems of ordinary linear differential equations, through nonlinear ordinary differential equations, to linear and nonlinear partial differential equations. Many chapters begin with a survey of mathematical techniques needed for the analysis. All problems discussed in this book belong to the class of singularly perturbed problems; that is, problems in which the structure of the limit equation is significantly different from that of the multiscale model. Such problems appear in all areas of science and can be attacked using many techniques. Methods of Small Parameter in Mathematical Biology will appeal to senior undergraduate and graduate students in applied and biomathematics, as well as researchers specializing in differential equations and asymptotic analysis.

Methods and Models in Mathematical Biology

Methods and Models in Mathematical Biology PDF

Author: Johannes Müller

Publisher: Springer

Published: 2015-08-13

Total Pages: 721

ISBN-13: 3642272517

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This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models.

Mathematical Modeling of Biological Processes

Mathematical Modeling of Biological Processes PDF

Author: Avner Friedman

Publisher: Springer

Published: 2014-09-19

Total Pages: 152

ISBN-13: 3319083147

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This book on mathematical modeling of biological processes includes a wide selection of biological topics that demonstrate the power of mathematics and computational codes in setting up biological processes with a rigorous and predictive framework. Topics include: enzyme dynamics, spread of disease, harvesting bacteria, competition among live species, neuronal oscillations, transport of neurofilaments in axon, cancer and cancer therapy, and granulomas. Complete with a description of the biological background and biological question that requires the use of mathematics, this book is developed for graduate students and advanced undergraduate students with only basic knowledge of ordinary differential equations and partial differential equations; background in biology is not required. Students will gain knowledge on how to program with MATLAB without previous programming experience and how to use codes in order to test biological hypothesis.

Modeling and Differential Equations in Biology

Modeling and Differential Equations in Biology PDF

Author: T. A. Burton

Publisher: CRC Press

Published: 1980-09-01

Total Pages: 300

ISBN-13: 9780824771331

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Persistence in lotka-volterra models of food chains and competition; Mathematical models of humoral immune response; Mathematical models of dose and cell cycle effects in multifraction radiotherapy; Theorical and experimental investigations of microbial competition in continuous culture; A liapunov functional for a class of reaction-diffusion systems; Stochastic prey-predator relationships; Coexistence in predator-prey systems; Stability of some multispecies population models; Population dynamics in patchy environments; Limit cycles in a model of b-cell simulation; Optimal age-specific harvesting policy for a cintinuous time-population model; Models involving differential and integral equations appropriate for describing a temperature dependent predator-prey mite ecosystem on apples.

Mathematical Modeling in Biology

Mathematical Modeling in Biology PDF

Author: Shandelle M. Henson

Publisher: CRC Press

Published: 2022-12-29

Total Pages: 339

ISBN-13: 100080609X

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Features Minimal pre-requisites beyond a solid background in calculus, such as a calculus I course. Suitable for upper division mathematics and sciences students and graduate-level biology students. Provides sample MATLAB codes and instruction in Appendices.

Space-Time Methods

Space-Time Methods PDF

Author: Ulrich Langer

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2019-09-23

Total Pages: 261

ISBN-13: 3110548488

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This volume provides an introduction to modern space-time discretization methods such as finite and boundary elements and isogeometric analysis for time-dependent initial-boundary value problems of parabolic and hyperbolic type. Particular focus is given on stable formulations, error estimates, adaptivity in space and time, efficient solution algorithms, parallelization of the solution pipeline, and applications in science and engineering.

Dynamical System Models in the Life Sciences and Their Underlying Scientific Issues

Dynamical System Models in the Life Sciences and Their Underlying Scientific Issues PDF

Author: Frederic Y M Wan

Publisher: World Scientific Publishing Company

Published: 2017-08-16

Total Pages: 400

ISBN-13: 9813143355

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Broadly speaking, there are two general approaches to teaching mathematical modeling: 1) the case study approach, and 2) the method based approach (that teaches mathematical techniques with applications to relevant mathematical models). This text emphasizes instead the scientific issues for modeling different phenomena. For the natural or harvested growth of a fish population, we may be interested in the evolution of the population, whether it reaches a steady state (equilibrium or cycle), stable or unstable with respect to a small perturbation from equilibrium, or whether a small change in the environment would cause a catastrophic change, etc. Each scientific issue requires an appropriate model and a different set of mathematical tools to extract information from the model. Models examined are chosen to help explain or justify empirical observations such as cocktail drug treatments are more effective and regenerations after injuries or illness are fast-tracked (compared to original developments). Volume I of this three-volume set limits its scope to phenomena and scientific issues that are modeled by ordinary differential equations (ODE). Scientific issues such as signal and wave propagation, diffusion, and shock formation involving spatial dynamics to be modeled by partial differential equations (PDE) will be treated in Vol. II. Scientific issues involving randomness and uncertainty are examined in Vol. III. Request Inspection Copy Contents: Mathematical Models and the Modeling CycleGrowth of a Population:Evolution and EquilibriumStability and BifurcationInteracting Populations:Linear InteractionsNonlinear Autonomous InteractionsHIV Dynamics and Drug TreatmentsIndex Theory, Bistability and FeedbackOptimization:The Economics of GrowthOptimization over a Planning PeriodModifications of the Basic ProblemBoundary Value Problems are More ComplexConstraints and Control:"Do Your Best" and the Maximum PrincipleChlamydia TrachomatisGenetic Instability and CarcinogenesisMathematical Modeling RevisitedAppendices:First Order ODEBasic Numerical MethodsAssignments Readership: Undergraduates in mathematical biology, mathematical modeling of dynamical systems, optimization and control, viral dynamics (infectious diseases), oncology.