Biologically-responsive Hybrid Biomaterials

Biologically-responsive Hybrid Biomaterials PDF

Author: Esmaiel Jabbari

Publisher: World Scientific

Published: 2010

Total Pages: 430

ISBN-13: 981429568X

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Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

Biologically Responsive Biomaterials for Tissue Engineering

Biologically Responsive Biomaterials for Tissue Engineering PDF

Author: Iulian Antoniac

Publisher: Springer Science & Business Media

Published: 2012-10-02

Total Pages: 261

ISBN-13: 1461443288

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Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.

Functional Biomaterials

Functional Biomaterials PDF

Author: Sougata Jana

Publisher: Springer Nature

Published: 2022-03-29

Total Pages: 524

ISBN-13: 9811671524

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This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Integrated Biomaterials for Biomedical Technology

Integrated Biomaterials for Biomedical Technology PDF

Author: Murugan Ramalingam

Publisher: John Wiley & Sons

Published: 2012-07-31

Total Pages: 436

ISBN-13: 1118423852

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This cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications. The volume consists of 12 chapters written by acknowledged experts of the biomaterials field and covers a wide range of topics and applications including: The different types of nanobiomaterials How to generate porous biomaterials for tissue engineering Calcium phosphate-based biomaterials intended for mineralized tissue regenerative applications Nanocrystalline form of calcium phosphates Design and fabrication of SiO2 nanoparticles New kinds of titanium alloy implants Injectable growth factor system based on bone morphogenetic proteins Impedance sensing of biological processes in mammalian cells Hydrogels-based implantable glucose sensors Molecular design of multifunctional polymers for gene transfection Hydrogels and their potential biomedical applications Hybrid biomaterials with high mechanical and biological properties

Functional Biomaterials

Functional Biomaterials PDF

Author: Anuj Kumar

Publisher: CRC Press

Published: 2023-09-22

Total Pages: 325

ISBN-13: 1000912086

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Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices

Tunable Hydrogels

Tunable Hydrogels PDF

Author: Antonina Lavrentieva

Publisher: Springer Nature

Published: 2021-05-31

Total Pages: 256

ISBN-13: 3030767698

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This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.

Switchable and Responsive Surfaces and Materials for Biomedical Applications

Switchable and Responsive Surfaces and Materials for Biomedical Applications PDF

Author: Johnathan Zhang

Publisher: Woodhead Publishing

Published: 2015-01-12

Total Pages: 0

ISBN-13: 9780857097132

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Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

Biomaterials Science

Biomaterials Science PDF

Author: Buddy D. Ratner

Publisher: Elsevier

Published: 1997-05-20

Total Pages: 497

ISBN-13: 0080500145

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This book introduces a subject that has profound impact on human health and considerable economic importance. The issues addressed include the biology, medical applications, markets, regulation, and ethical issues involved in biomaterials science. This spectrum of issues reflects the interdisciplinary nature of the field. Provides a strong, cohesive compilation unlike any other currently on the market Covers the entire spectrum of biomaterials and their use in medicine Contributions of leaders in the biomaterials field

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